Growth and characterization of a chalcone derivative DMMC with strong SHG efficiency for NLO applications

Hu, Siyuan; Zhao, Tongpeng; Xu, Kai; Ji, Shaohua; Cao, Lifeng; Teng, Bing

doi:10.1016/j.ijleo.2021.166410

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…During the reaction, the base (catalyst) attacks α-hydrogen of acetophenone and forms an enolate anion (carbanion). The carbanion attacks the carbonyl group of benzaldehyde and forms a β-hydroxycarbonyl intermediate, from which chalcone is obtained [ 135 , 136 , 137 , 138 , 139 , 140 , 141 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones

Constantinescu

Mihis

2022

IJMS

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ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin assembly through polymerization. A series of natural and synthetic chalcones have been reported to have very good anticancer activity, with a half-maximal inhibitory concentration lower than 1 µM. By modulation, it is observed in case of the first mechanism that methoxy substituents on the aromatic cycle of acetophenone residue and substitution of phenyl nucleus by a heterocycle and by methoxy or hydroxyl groups have a positive impact. To inhibit tubulin, compounds bind to colchicine binding site. Presence of methoxy groups, amino groups or heterocyclic substituents increase activity.

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Section: Flavonoidsmentioning

confidence: 99%

Two Important Anticancer Mechanisms of Natural and Synthetic Chalcones

Constantinescu

Mihis

2022

IJMS

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“…Molecular organic crystals without ionic bonds have no similar problems and can be used in the low-frequency band . Among many molecular types of organic NLO crystals, chalcone has attracted widespread attention owing to its application value not only in biopharmaceuticals but also in nonlinear optics and excessive synthesis flexibility. − Although some chalcone derivatives with the D−π–A−π–D configuration have been found to have NLO properties, such as DAMO (C 18 H 19 NO 2 , P 2 1 ), MPP (C 15 H 13 NO 2 , Pna 2 1 ), DMMC (C 18 H 18 O 4 , P 2 1 ), and so on, they also have high powder SHG activity; − however, most of the reported chalcone crystals are third-order nonlinear optical crystals with a centrosymmetric structure. To the best of our knowledge, there are fewer high-performing second-order NLO crystals with a chalcone structure.…”

Section: Introductionmentioning

confidence: 99%

Molecular Structure Design, Crystal Growth, and Characterization of New Types of Organic Nonlinear Optical Chalcone Crystals

Chen

et al. 2022

Crystal Growth & Design

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Chalcone structures obtained by structural tailoring are an important class of molecular organic nonlinear optics (NLO) crystals that can be used for multiple purposes. In this work, two novel chalcone compound crystals with noncentrosymmetric structures, 6MN3MPP (C 21 H 18 O 3 , Pca2 1 ) and 6MN4MPP (C 21 H 18 O 3 , Pn), were designed and grown by extending the π-conjugation and structure-modifying strategy. On this basis, the second harmonic generation (SHG) efficiency, thermal stability, transmission spectra, dielectric constant, and photoluminescence properties of the crystal were characterized, and the hyperpolarizability of the crystal was theoretically calculated. The results show that the synthesized crystals exhibit higher crystal transparency (≥70%), higher melting point, and lower dielectric constant (ε r ≈ 6.5) compared with other reported chalcone NLO crystals. In particular, the SHG intensity of the 6MN3MPP crystal is 4.3 times higher than that of the KDP crystal. All of the results show that the two newly synthesized compounds have good application prospects as NLO crystals.

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