“…NAD dependent and independent-effect of various substituted trimethoxybenzamides in rat brain homogenates 0 Structure-activity relationships-various substituted trimethoxybenzamides evaluated for anticonvulsant activity in mice and effect on enzyme activity in rat brain homogenates Central nervous system (CNS) depressant and hypotensive properties associated with reserpine are due to the presence of a 3,4,5-trimethoxybenzene moiety (1)(2)(3)(4)(5)(6). Many drugs affecting CNS activity have amide or thioamide linkage as the common molecular structural units (7,8).…”