Growth and Development in a Heliox Incubator Environment: A Long-Term Safety Study

Singhaus, Clifford J.; Utidjian, Levon; Akins, Robert E.; Miller, Thomas L.; Shaffer, Thomas H.; Touch, Suzanne M.

doi:10.1159/000096968

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…The effect of 14 days in a heliox (21% oxygen, 79% helium) environment has been tested in 4-day-old rabbit kits. No differences in weight, growth factors, tissue/organ weights, blood chemistries, or muscle enzyme activity were detected between heliox-and air-exposed animals (106). This finding has relevance for human infants treated with heliox to decrease gas viscosity in obstructive lung conditions.…”

Section: Other Newborn Rabbit Modelsmentioning

confidence: 63%

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models

D’Angio

Ryan

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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Bronchopulmonary dysplasia (BPD) is an important lung developmental pathophysiology that affects many premature infants each year. Newborn animal models employing both premature and term animals have been used over the years to study various components of BPD. This review describes some of the neonatal rabbit studies that have contributed to the understanding of BPD, including those using term newborn hyperoxia exposure models, premature hyperoxia models, and a term newborn hyperoxia model with recovery in moderate hyperoxia, all designed to emulate aspects of BPD in human infants. Some investigators perturbed these models to include exposure to neonatal infection/inflammation or postnatal malnutrition. The similarities to lung injury in human premature infants include an acute inflammatory response with the production of cytokines, chemokines, and growth factors that have been implicated in human disease, abnormal pulmonary function, disordered lung architecture, and alveolar simplification, development of fibrosis, and abnormal vascular growth factor expression. Neonatal rabbit models have the drawback of limited access to reagents as well as the lack of readily available transgenic models but, unlike smaller rodent models, are able to be manipulated easily and are significantly less expensive than larger animal models.

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Section: Other Newborn Rabbit Modelsmentioning

confidence: 63%

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models

D’Angio

Ryan

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…It was also observed that long-term exposure to heliox caused no long-term differences in growth or development in newborn rabbits [18] . Poor heliox tolerance (hypoxia, decrease in skin temperature, wakening and crying) was described in spontaneously breathing infants with BPD when heliox was administered into a plexiglass chamber [19] .…”

Section: Discussionmentioning

confidence: 95%

Use of Heliox in the Management of Neonates with Meconium Aspiration Syndrome

Szczapa¹,

Gadzinowski²

2011

Neonatology

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Background: Helium-oxygen mixture (heliox) ventilation has been known as an alternative treatment in patients with airway obstruction. Because of the physical properties of heliox, mechanical ventilation with this gas mixture may offer advantages in the management of respiratory failure associated with meconium aspiration syndrome (MAS). Objectives: The purpose of this pilot study was to assess the effect of short-term mechanical ventilation with heliox in newborns with MAS on vital signs, oxygenation, acid-base balance and respiratory function parameters. Methods: The study was carried out in newborns with respiratory failure requiring mechanical ventilation due to MAS. Eight patients were ventilated using pressure-controlled synchronized intermittent mandatory ventilation. Parameters of respiratory function, oxygenation, acid-base balance and vital signs were recorded at baseline, then twice during 1 h of heliox ventilation and finally twice during 1 h after switching back to air-oxygen ventilation. Results: Mechanical ventilation with heliox did not affect vital signs and the infants’ clinical condition remained stable during the study. Heliox ventilation was associated with a nonsignificant increase in tidal volume, minute ventilation and peak expiratory flow rate values. Mechanical ventilation with heliox allowed the use of significantly lower FiO₂, with a significant decrease in alveolar-arterial oxygen tension difference and a decrease in the oxygenation index which was not statistically significant. There was also a significant increase in the PaO₂/FiO₂ ratio during heliox ventilation. Conclusions: Ventilation with a helium and oxygen mixture had a positive effect on the selected parameters of oxygenation, while its effects on other respiratory parameters were relatively small.

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“…These benefits of HFNC are amplified with the use of Heliox, since it is unique biophysical properties aid in improving work of breathing, improves ventilation, decreases oxygen needs, may enhance nasopharyngeal washout (more effective diffusion of Heliox), and further reduces lung inflammation . In addition, Heliox provides an effective steady state thermal environment during early development …”

Section: Discussionmentioning

confidence: 99%

High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model

Jassar

Vellanki

Zhu

et al. 2014

Pediatric Pulmonology

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Background High flow nasal cannula (HFNC) improves ventilation by washing out nasopharyngeal dead space while delivering oxygen. Heliox (Helium-oxygen gas mixture), a low density gas mixture, decreases resistance to airflow, reduces the work of breathing and facilitates distribution of inspired gas. Excessive lung work and potential injury increases the workload on the immature diaphragm predisposing the muscle to fatigue and can lead to inflammatory and oxidative stress, thereby contributing to impaired diaphragmatic function. We tested the hypothesis that HFNC with Heliox will decrease the work of breathing thereby unloading the neonatal diaphragm and potentially reducing diaphragmatic injury. Methods Spontaneously breathing neonatal pigs were randomized to Nitrox (Nitrogen-oxygen gas mixture) or Heliox and studied over 4 hrs following oleic acid injury. Gas exchange, pulmonary mechanics indices and systemic markers of inflammation were measured serially. Diaphragm inflammation biomarkers and histology for muscle injury were assessed at termination. Results Heliox breathing animals demonstrated decreased respiratory load and work of breathing with lower pressure- rate product, lower labored breathing index, and lower levels of diaphragmatic inflammatory markers and muscle injury score as compared to Nitrox. Conclusion These results suggest that HFNC with Heliox is a useful adjunct to attenuate diaphragmatic fatigue in the presence of lung injury by unloading the diaphragm, resulting in a more efficient breathing pattern and decreased diaphragm injury.

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Growth and Development in a Heliox Incubator Environment: A Long-Term Safety Study

Cited by 7 publications

References 48 publications

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models

Use of Heliox in the Management of Neonates with Meconium Aspiration Syndrome

High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model

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