1990
DOI: 10.1159/000146866
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Growth and Differentiation of Fetal Rat Limb Buds Transplanted in Athymic (Nude) Mice

Abstract: Limb buds of day 14 rat fetuses were cut into pieces and transplanted into the subcutaneous tissue of athymic (nude) mice. In day 14 fetal limbs, mesenchymal cells have begun to condense to form cartilaginous anlage, but no cartilage has been formed. Within 7 days after grafting, masses of hyaline cartilage developed. Numerous osteoblasts appeared, and new bone formation began by 14 days. By 20 days, osteoclasts appeared, and the formation of bone trabeculae and marrow cavities progressed. The cytological char… Show more

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“…Therefore, the results of in vitro cultures should be finally verified in vivo (Bulic‐Jakus et al, 2016; Ehnert et al, 2020). The most used in vivo techniques are topic transplantation of bone or cartilage grafts grown in vitro or ectopic subcutaneous transplantation (Shiota et al, 1990). Our results obtained previously regarding transplantation under the kidney capsule of in vitro cultivated gastrulating embryos‐proper showed that this site is optimal for the continuation of chondrogenesis, osteogenesis, neurogenesis, and development of skin appendages.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the results of in vitro cultures should be finally verified in vivo (Bulic‐Jakus et al, 2016; Ehnert et al, 2020). The most used in vivo techniques are topic transplantation of bone or cartilage grafts grown in vitro or ectopic subcutaneous transplantation (Shiota et al, 1990). Our results obtained previously regarding transplantation under the kidney capsule of in vitro cultivated gastrulating embryos‐proper showed that this site is optimal for the continuation of chondrogenesis, osteogenesis, neurogenesis, and development of skin appendages.…”
Section: Introductionmentioning
confidence: 99%