Growth and division—not a one-way road

Goranov, Alexi I.; Amon, Angelika

doi:10.1016/j.ceb.2010.06.004

Cited by 42 publications

(52 citation statements)

References 47 publications

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“…Our studies suggest that this reported colocalization may result from direct (or indirect) physical interaction. In addition, Goranov et al have suggested that direct regulation of actin remodeling may be an important biochemical mechanism for eukaryotic cell size control (19,20).…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells

Kim

et al. 2011

Molecular and Cellular Biology

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Following DNA damage, human cells undergo arrests in the G 1 and G 2 phases of the cell cycle and a simultaneous arrest in cell size. We previously demonstrated that the cell size arrest can be uncoupled from the cell cycle arrest by mutational inactivation of the PTEN tumor suppressor gene. Here we show that the cell size checkpoint is inducible by DNA-damaging chemotherapeutic agents as well as by ionizing radiation and is effectively regulated by PTEN but not by its oncogenic counterpart, PIK3CA. Mutational analysis of PTEN and pharmacological inhibition of Akt revealed that modulation of Akt phosphorylation is unnecessary for cell size checkpoint control. To discover putative PTEN regulators and/or effectors involved in size checkpoint control, we employed a novel endogenous epitope tagging (EET) approach, which revealed that endogenous PTEN interacts at the membrane with an actin-remodeling complex that includes actin, gelsolin, and EPLIN. Pharmacological inhibition of actin remodeling in PTEN ؉/؉ cells recapitulated the lack of size checkpoint control seen in PTEN ؊/؊ cells. Taken together, these results provide further support for the existence of a DNA damage-inducible size checkpoint that is regulated by a major tumor suppressor, and they provide a novel Akt-independent mechanism by which PTEN controls cell size.

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Section: Discussionmentioning

confidence: 99%

Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells

Kim

et al. 2011

Molecular and Cellular Biology

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“…The second mechanism in which cell division inhibits cell growth comes from studies in yeast and mammalian cells [148]. By measuring a single cell growth rate during the cell cycle progression in both yeast and mammalian cells, several groups have discovered that the cell growth rate during the cell cycle is not constant but changes during the cell cycle stages.…”

Section: Interaction Between Cell Growth and Cell Division In Cell Anmentioning

confidence: 99%

“…The first mechanism is that cell growth is dominant to cell division [115]. The second mechanism is that cell proliferation inhibits cell growth during the cell cycle [148]. The third mechanism is that cell growth and cell division are controlled coordinately by a growth coordinator.…”

Section: Interaction Between Cell Growth and Cell Division In Cell Anmentioning

confidence: 99%

“…The cell growth rate is high during G1 phase but is decreased during mitosis [154][155][156][157], suggesting that cell division may inhibit cell growth. It has been proposed that increased Cdk activity and polarized actin cytoskeleton during mitosis may be responsible for the inhibition of cell growth [148].…”

Section: Interaction Between Cell Growth and Cell Division In Cell Anmentioning

confidence: 99%

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Molecular mechanism of size control in development and human diseases

Yang

2011

Cell Res

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How multicellular organisms control their size is a fundamental question that fascinated generations of biologists. In the past 10 years, tremendous progress has been made toward our understanding of the molecular mechanism underlying size control. Original studies from Drosophila showed that in addition to extrinsic nutritional and hormonal cues, intrinsic mechanisms also play important roles in the control of organ size during development. Several novel signaling pathways such as insulin and Hippo-LATS signaling pathways have been identified that control organ size by regulating cell size and/or cell number through modulation of cell growth, cell division, and cell death. Later studies using mammalian cell and mouse models also demonstrated that the signaling pathways identified in flies are also conserved in mammals. Significantly, recent studies showed that dysregulation of size control plays important roles in the development of many human diseases such as cancer, diabetes, and hypertrophy.

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“…The maturation process involves, among other things, the melanization of the appressorium, the generation of internal turgor pressure, and the deposition of cytoskeletal components at the base of the appressorium pore to allow the formation of the penetration peg, where all the turgor pressure will be focused [64]. As mitotic growth arrest is thought to help cells to reorganize their structure and adapt to the increased energy demands needed for subsequent cell division or regeneration [65], it makes sense to stop cell wall expansion in the appressorium to allow maturation to proceed. The next step during the formation of a functional appressorium is the remodeling of the F-actin cytoskeleton to form a toroidal network at the base of the appessorium, which is organized by septins.…”

Section: Invasion Tools: Appressorium Formation and Cell Cycle Regulamentioning

confidence: 99%

Virulence-specific cell cycle and morphogenesis connections in pathogenic fungi

Pérez-Martı́n

Bardetti

Castanheira

et al. 2016

Seminars in Cell & Developmental Biology

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To initiate pathogenic development, pathogenic fungi respond to a set of inductive cues. Some of them are of an extracellular nature (environmental signals), while others are intracellular (developmental signals). These signals must be integrated into a single response whose major outcome is changes in the morphogenesis of the fungus. The regulation of the cell cycle is pivotal during these cellular differentiation steps; therefore, cell cycle regulation would likely provide control points for infectious development by fungal pathogens.Here, we provide clues to understanding how the control of the cell cycle is integrated with the morphogenesis program in pathogenic fungi, and we review current examples that support these connections. Pérez-Martín et al., 2016 3

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Growth and division—not a one-way road

Cited by 42 publications

References 47 publications

Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells

Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells

Molecular mechanism of size control in development and human diseases

Virulence-specific cell cycle and morphogenesis connections in pathogenic fungi

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