Growth and liver morphology after long-term ethanol consumption of rats

Wiel, Jeanine A.G. van de; Duijf, C. M. P.; Pertijs, Jeanne; Peereboom-Stegeman, J.H.J. Copius; Bos, R.P.

doi:10.1258/002367790780866263

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…Early, late single hit and double hit with alcohol had no effect on the hepatosomatic index in the present study. In line with our finding, another research group found that alcohol consumption does not affect the hepatosomatic index of rats [ 46 ]. However, in contrast to our findings, other studies showed that alcohol consumption increased liver weight [ 47 , 48 ].…”

Section: Discussionsupporting

confidence: 92%

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

et al. 2023

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Alcohol intake at different developmental stages can lead to the development of alcohol-induced fatty liver disease (AFLD). Zingerone (ZO) possess hepato-protective properties; thus, when administered neonatally, it could render protection against AFLD. This study aimed to evaluate the potential long-term protective effect of ZO against the development of AFLD. One hundred and twenty-three 10-day-old Sprague–Dawley rat pups (60 males; 63 females) were randomly assigned to four groups and orally administered the following treatment regimens daily during the pre-weaning period from postnatal day (PND) 12–21: group 1—nutritive milk (NM), group 2—NM +1 g/kg ethanol (Eth), group 3—NM + 40 mg/kg ZO, group 4—NM + Eth +ZO. From PND 46–100, each group from the neonatal stage was divided into two; subgroup I had tap water and subgroup II had ethanol solution as drinking fluid, respectively, for eight weeks. Mean daily ethanol intake, which ranged from 10 to 14.5 g/kg body mass/day, resulted in significant CYP2E1 elevation (p < 0.05). Both late single hit and double hit with alcohol increased liver fat content, caused hepatic macrosteatosis, dysregulated mRNA expression of SREBP1c and PPAR-α in male and female rats (p < 0.05). However, neonatal orally administered ZO protected against liver lipid accretion and SREBP1c upregulation in male rats only and attenuated the alcohol-induced hepatic PPAR-α downregulation and macrosteatosis in both sexes. This data suggests that neonatal orally administered zingerone can be a potential prophylactic agent against the development of AFLD.

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Section: Discussionsupporting

confidence: 92%

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

et al. 2023

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“…Total monounsaturated fatty acids (MUFA) were decreased in both serum (p<0.05) and liver phospholipids (p<0.001). (20). Some observa tion suggests that alcohol consumption influenced food consumption and weight gain in animals (22).…”

Section: Methodsmentioning

confidence: 99%

Effects of Different Quantities of Fat on Serum and Liver Lipids, Phospholipid Class Distribution and Fatty Acid Composition in Alcohol-Treated Rats

Ristić‐Medić¹,

Ristic²,

Tepšić³

2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe present study investigated the quantitative effect of dietary fats and inges tion of alcohol on serum and liver lipids, fatty acid bound to phospholipids and their class distribution of male Wistar rats. The rats in C (control) and A (alcohol) groups were fed a standard laboratory diet, HFC (high fat-control) and HFA (high fat-alcohol) groups were fed a high fat diet (standard diet supplemented with 20g%w/w, sunflower oil: lard mixture 1: 1) for 6wk. Alcohol-treated rats consumed alcohol at the rate of 9g/kgbw/d (15-20% energy). Liver phospholipid (PL) content was decreased, and phospholipid/cholesterol liver molar ratio increased in the alcohol treated rats. The proportion of serum sphingophospho lipid (Sph) was significantly lower and proportion of phosphatidylcholin (PC) significantly higher in serum PL in alcohol-treated rats. Phospholipid class distribution was unaffected by alcohol feeding in liver. Significantly lower levels of 16:1n-7 and higher levels of 20:5n-3 and 22:4n-6 in the serum PL were observed in the alcohol-treated rats. The groups on the HF diet increased levels of 20:4n-6, 22:4n-6 and total n-6, polyunsaturated fatty acid (PUFA)and decreased levels of 18:1n-9 and total monounsaturated fatty acids (MUFA)in both liver and serum PL, but n-3 fatty acid increased in serum PL and decreased in liver PL compared to groups on the standard diet. Alcohol fat interaction was evident in MUFA and PUFA/SFA in serum PL and n-6, MUFA, PUPA and polyunsaturated/saturated fatty acid ratios (PUFA/SFA) in liver PL. This study showed that the high fat intake in alcohol-treated rats increased levels of 20:4n-6, 22:4n-6 and 20:4/18:2 ratio, and decreased level of 18:1n -9 in liver and serum phospholipids.

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Influence of long-term ethanol treatment on in vitro biotransformation of benzo (a)pyrene in microsomes of the liver, lung and small intestine from male and female rats

Wiel

Meuwissen

Kooy

et al. 1992

Biochemical Pharmacology

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Growth and liver morphology after long-term ethanol consumption of rats

Cited by 7 publications

References 17 publications

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models

Effects of Different Quantities of Fat on Serum and Liver Lipids, Phospholipid Class Distribution and Fatty Acid Composition in Alcohol-Treated Rats

Influence of long-term ethanol treatment on in vitro biotransformation of benzo (a)pyrene in microsomes of the liver, lung and small intestine from male and female rats

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