Growth and Metabolic Responses in Low-Birth-Weight Infants Fed Human Milk Fortified with Human Milk Protein or with a Bovine Milk Protein Preparation

Moro, Guido; Minoli, I; Fulconis, F.; Clementi, Mariangela; Räihä, N. C. R.

doi:10.1097/00005176-199108000-00006

Cited by 24 publications

(16 citation statements)

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“…The plasma amino acid profiles in LBW infants fed human milk fortified with bovine proteins [4,14] differ significantly from those observed in LBW infants fed exclusively human milk protein [11,13,20,21,22]. The amino acid composition of these bovine fortifiers depends on the amino acid composition of the protein used but it does not fulfill the nutritional needs of preterm infants.…”

Section: Introductionmentioning

confidence: 92%

“…More recently, a bovine milk protein fortifier has been developed with an amino acid composition similar to that of the nutritionally available human milk protein [7]. Initial studies have shown that the amino acid profiles of LBW infants fed human milk enriched with this new fortifier were virtually similar to those of LBW infants fed the same amounts of human milk protein [11,20], Nevertheless, there are no studies comparing the meta= bolic response of LBW infants fed this new fortifier with that of LBW infants fed other bovine protein supplements at similar protein and energy intakes.…”

Section: Introductionmentioning

confidence: 99%

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Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

Boehm¹,

Borte²,

Bellstedt

et al. 1993

Eur J Pediatr

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Serum preprandial essential amino acid, urea and prealbumin concentrations, and growth rates were studied in appropriate for gestational age low birth weight infants fed one of three regimens: (1) human milk enriched with human milk protein (n = 17); (2) bovine whey protein hydrolysate (n = 18; and (3) a mixture of bovine proteins, peptides and amino acids designed to have an amino acid composition close to that of human milk proteins (n = 18). Energy and nitrogen intakes were similar in all groups. Growth rates and gross metabolic responses did not differ between the feeding groups. There were also no differences in the amino acid profiles between those infants fed human milk protein fortifier and mixed bovine protein fortifier. Infants fed the whey fortifier had significantly higher threonine concentrations in comparison to those fed exclusively human milk protein (287 +/- 63 mumol/l vs 168 +/- 26 mumol/l) whereas the levels of some other essential amino acids (i.e. valine, leucine, lysine, histidine, phenylalanine and tryptophan) were lower. The results indicate that growth rates and gross metabolic indices do not depend on the protein quality of human milk fortifiers. However, the addition of well balanced mixtures of bovine proteins to human milk results in amino acid profiles similar to those observed in LBW infants fed similar amounts of human milk proteins.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

Boehm¹,

Borte²,

Bellstedt

et al. 1993

Eur J Pediatr

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“…Reports of the plasma amino acids values in VLBW infants fed the same bovine milk protein fortifier as used in this study or HM-protein fortifier with similar protein intakes have shown that the plasma amino acid profiles in the infants fed the bovine milk fortifier were closely related to those found in infants fed exclusively HM protein [15].…”

Section: Discussionmentioning

confidence: 57%

“…In initial studies concerning growth rates and serum indices of protein metabolism of VLBW infants fed HM enriched with this bovine milk protein fortifier or exclusively HM protein at similar intakes [5,15] no differences could be found between these two fortifiers. However, metabolic balances have not yet been performed.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen and fat balances in very low birth weight infants fed human milk fortified with human milk or bovine milk protein

Boehm¹,

Müller

Senger

et al. 1993

Eur J Pediatr

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The study was designed to compare two different human milk fortifiers in a group of very low birth weight (VLBW) infants by analysing nitrogen and fat balances, serum concentrations of alpha-amino-nitrogen, urea, and prealbumin as well as growth rates when human milk enriched with one of the two studied fortifiers was fed to the infants. Fortifier A contained different bovine proteins, peptides and amino acids and had an amino acid composition comparable to that of the nutritional available proteins in human milk, with carbohydrates, and minerals. Fortifier B was composed of freeze-dried skimmed human milk and minerals to achieve a similar macronutrient composition in both fortifiers. Eleven infants were fed with human milk enriched with fortifier A and 13 with fortifier B. After a 10-day equilibration period, a 3-day metabolic balance was performed. On the 14th day of the study blood was obtained preprandially for serum analysis and growth rates were estimated. The nitrogen absorption rate (93.8% vs 93.5%) as well as the retention rate (80.8% vs 78.5%) were no different between the groups. The fat absorption rate (92.3% vs 91.5%) as well as the weight gain (32.1 vs 31.1 g/day) were similar and there were no differences in the serum parameters studied. The results indicate that feeding VLBW infants with human milk enriched with a well-balanced bovine fortifier fulfil their nutritional requirements as well as diets composed exclusively of human milk protein.

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“…The nitro- Table 1. Plasma amino acid concentrations in premature infants fed protein-fortified human milk at the end of the study (mean + SD) (34…”

Section: Fortijication With Bovine Milk Protein Preparationsmentioning

confidence: 99%

Protein fortification of human milk for feeding preterm infants

Räihä

1994

Acta Paediatrica

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Growth and Metabolic Responses in Low-Birth-Weight Infants Fed Human Milk Fortified with Human Milk Protein or with a Bovine Milk Protein Preparation

Cited by 24 publications

References 0 publications

Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

Protein quality of human milk fortifier in low birth weight infants: Effects on growth and plasma amino acid profiles

Nitrogen and fat balances in very low birth weight infants fed human milk fortified with human milk or bovine milk protein

Protein fortification of human milk for feeding preterm infants

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