Growth and Neurodevelopmental Outcome in Preterm LBW Infants with Sepsis in India: A Prospective Cohort

Pawar, Sunil Jayaram; Oleti, Tejo Pratap; Bharathi, S Mangala; Tipparaju, Shyamsunder; Mustafa, Ershad

doi:10.1155/2018/5735632

Cited by 10 publications

(9 citation statements)

References 13 publications

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“… 11 , 13 , 14 Likewise, another study described neonatal sepsis with NEC to be associated with increased neurodevelopmental impairment in low birth-weight survivors manifesting as CP. 16 Several human and animal studies have verified the presence of bacterial exotoxins-induced cytokine-release from microglia and astrocytes, resulting in a systemic inflammatory response syndrome, which further increases the blood-brain barrier permeability causing neuronal damage and apoptosis. 34 - 37 The consequent arterial hypotension and the lability of blood pressure during sepsis, coupled with coagulopathy, lead to cerebral ischemia-reperfusion injury impairing neuronal oxygenation and cerebral autoregulation.…”

Section: Discussionmentioning

confidence: 99%

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Late-onset Sepsis in Preterm Neonates is Associated with Higher Risks of Cerebellar Hemorrhage and Lower Motor Scores at Three Years of Age

Kartam¹,

Embaireeg²,

Albalool³

et al. 2022

Oman Med J

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Background: Sepsis is associated with adverse neonatal outcomes, including diffuse white matter injury (WMI) which may predispose to developmental delay. Objective: To evaluate the impact of late-onset sepsis (LOS) in preterm infants on brain injury and neurodevelopmental outcomes at 36 months corrected age (CA). Design: Retrospective cohort study. Setting: Neonatal Sepsis Registry at Neonatal Department, Al-Sabah Maternity hospital, Kuwait. Participants: A total of 203 neonates (gestational age (GA) between 24-32 weeks) were admitted between January 2017 and December 2017. Neonates were stratified into no sepsis, into early-onset sepsis (first onset of sepsis ≤72 hours postnatally), and LOS (>72 hours postnatally) 2 Main outcome: Brain injury and neurodevelopmental outcomes at 36 months CA were evaluated using Miller score and Bayley-III scales of infant development, respectively. Results: Sixteen neonates had early-onset sepsis with Klebsiella pneumonia and group-B streptococcus, and 93 developed LOS with K. pneumonia and gram-positive cocci in clusters. Intraventricular hemorrhage (n=68) and WMI (n=42) showed no group-wise differences. Higher cerebellar hemorrhage risk (adjusted odds ratio=4.6 (1.3-18.6); p=0.03) and lower motor composite scores (adjusted β=-9.5 (-16.4 to -2.7); p=0.007) were observed with LOS. Conclusions: LOS in preterm neonates is a significant risk factor predisposing to cerebellar hemorrhage and lower motor scores by three years of age.

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Section: Discussionmentioning

confidence: 99%

“… 12 Similarly, gastrointestinal infections like necrotizing enterocolitis (NEC) may trigger systemic inflammatory response resulting in significant neuronal injury with neurodevelopmental implications visible at 18–22 months follow-up. 7 , 13 - 16 …”

Section: Introductionmentioning

confidence: 99%

Late-onset Sepsis in Preterm Neonates is Associated with Higher Risks of Cerebellar Hemorrhage and Lower Motor Scores at Three Years of Age

Kartam¹,

Embaireeg²,

Albalool³

et al. 2022

Oman Med J

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“…Another study showed that LBW was a predictor of stunting in children aged 0-11 months (Sartika et al, 2021). Babies born with low birth weight have a very high risk of growth deficiency (Pawar et al, 2018). Low birth weight is an indication of nutritional deficiency in the baby while in the womb (Zhao et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Risk Factor Analysis of Family Characteristics and Health History of Children Under Five on the Incidence of Stunting in Sidenreng Rappang, South Sulawesi, Indonesia

Sulaiman,

Febrianti,

Said

et al. 2021

J EPIDEMIOL PUBLIC HEALTH

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Backround: Stunting was one of the global nutritional problems that are still widely found, especially in developing countries. in Asia, 87 million children were stunted. This study aimed to look at the risk of family characteristics and health history on the incidence of stunting. Subjects dan Method: This was a case-control study conducted in the Sidenreng Rappang district. The dependent variables were family characteristics consisting of maternal education and household members and health history consisting of LBW and infectious diseases. The independent variable was stunting. The target population in this study was all stunting toddlers in the district based on data from the 2019 statistical agency report. The sample selection technique was simple random sampling. The case samples obtained was 51 respondents and the control was 51 respondents so the total sample was 102 respondents. The data were using a questionnaire as a variable measuring instrument. The data were analyzed using logistic regression. Results: We found toddlers from mothers with low education are more at risk of stunting than those with higher education (OR= 2.89; CI= 1.24 to 6.74; p=0.022). Toddlers who live with more than 4 family members were more at risk of stunting than 4 people or less (OR= 0.63; CI= 0.23 to 1.87; p=0.596). Toddlers with low birth weight were more at risk of stunting than those with normal birth weight (OR= 10.44; CI= 3.28 to 33.30; p=0.000). Toddlers with a history of infection were more at risk of stunting than those without a history of infection (OR= 2.50; CI= 1.10 to 5.64; p=0.043). Conclusion:The highest risk factor for stunting is the low birth weight factor.

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“…There was a significant association between neonatal sepsis, birth asphyxia, convulsions andNDD. [9][10][11] Studies also reported that the children with severe acute malnutrition, and lower head circumference were significantly associated with developmental delays. 12,13…”

Section: Multiple Nddsmentioning

confidence: 99%

Prevalence and correlates of neurodevelopmental disorders among children in India: a narrative review

Gaikwad

Lagala

2020

Int J Contemp Pediatr

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Neurodevelopmental disorders (NDD) are seen disproportionately affecting the low-income communities. Paucity of consistent and large-scale studies in India and variations in assessment and diagnostic tools reduce the scope for generalization of prevalence estimates to national level. This review tried to consolidate the existing community-based evidence of the prevalence of NDDs, risk factors and comorbidities among children in India. We searched studies related to the review objectives on search engines PubMed and Google Scholar. The community or school-based studies in India, published in English language were included. The prevalence of each of these NDDs differed in different locations and age groups. The prevalence appeared to be increasing with increase in age. Non-institutional delivery, perinatal asphyxia or delayed crying, low birth weight or prematurity, neonatal illness or neurological infections were significantly associated with the NDDs. Most of the significant risk factors are modifiable with the help of effective programs to improve maternal and child healthcare and nutrition. Further large-scale, good-quality epidemiological studies in community settings are needed to develop and prioritize the delivery of the prevention and rehabilitation interventions.

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Growth and Neurodevelopmental Outcome in Preterm LBW Infants with Sepsis in India: A Prospective Cohort

Cited by 10 publications

References 13 publications

Late-onset Sepsis in Preterm Neonates is Associated with Higher Risks of Cerebellar Hemorrhage and Lower Motor Scores at Three Years of Age

Late-onset Sepsis in Preterm Neonates is Associated with Higher Risks of Cerebellar Hemorrhage and Lower Motor Scores at Three Years of Age

Risk Factor Analysis of Family Characteristics and Health History of Children Under Five on the Incidence of Stunting in Sidenreng Rappang, South Sulawesi, Indonesia

Prevalence and correlates of neurodevelopmental disorders among children in India: a narrative review

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