Growth and pectate-lyase activity of the ruminal bacterium Lachnospira multiparus in the presence of short-chain organic acids

Paggi, Roberto A.; Rodrı́guez, Carmen; Fay, J. P.

doi:10.1111/j.1472-765x.2005.01717.x

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…The present study also showed that the family Lachnospiraceae (genus Lachnospira , phylum Firmicutes) tended to be positively associated with propionic acid ( p < 0.01), while butyric acid did not reach significance ( p = 0.10), suggesting possible divergence in bacteria producing these SCFAs. Indeed, the production of propionic and butyric acids by the same bacterium is unusual [60]. Propionate can also be produced by microbiota from phylum Bacteroidetes [61], but we did not detect this association.…”

Section: Discussionmentioning

confidence: 62%

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

et al. 2019

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Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCFAs, metabolome analysis). These outcomes were compared between obese and non-obese men, after adjusting for age. The results showed that lipopolysaccharide-binding protein (LBP), the ratio of LBP to CD14 (LBP/CD14), and SCFAs (propionic, butyric, isovaleric) were higher in obese (n = 41, age 58 years, BMI 36 kg/m2) versus non-obese (n = 34, age 55 years, BMI 26 kg/m2) men. BMI correlated positively with LBP, LBP/CD14 (p < 0.05 for both) and SCFAs (propionic, butyric, isovaleric, p < 0.01 for all). In the regression analysis, LBP, LBP/CD14, propionic and butyric acids were independent determinants of BMI. The study showed for the first time that selected microbiota biomarkers (LBP, LBP/CD14, propionic and butyric acids) together with several other relevant risks explained 39%–47% of BMI variability, emphasizing that factors other than microbiota-related biomarkers could be important. Further research is needed to provide clinical and mechanistic insight into microbiota biomarkers and their utility for diagnostic and therapeutic purposes.

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Section: Discussionmentioning

confidence: 62%

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

et al. 2019

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“…Many Lachnospira strains produce butyrate, which plays a crucial role in the maintenance of human gut health [40]. These bacteria produce short-chain fatty acids, which can act as anti-in ammatory agents [40]. This may explain how Tibetans with a low dietary ber intake maintain gut health.…”

Section: Discussionmentioning

confidence: 99%

Succession of the Gut Microbiome in the Tibetan Population of the Minjiang River Basin

Sun

et al. 2021

Preprint

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Background: Tibetans are one of the oldest ethnic groups in China and South Asia. Tibetans have a unique lifestyle and a long history, which leads to the particularity of the composition and function of their gut microflora. Tibetans in the Minjiang River basin have gradually increased their migration to the Chengdu Plain in recent years. Based on the analysis of 1059 Tibetans in the Minjiang River basin at an altitude of 500-4001 m, we analyzed the characteristics of the gut microbiome and further elaborated the main factors affecting the succession of the gut microbiome in the Tibetan population.Results: Our study found that the dominant phyla of the Tibetan population were Bacteroidetes and Firmicutes, and the main genera were Prevotella and Bacteroides. To further study the factors affecting the gut microbial composition of the Tibetan population, 115 total parameters of 7 categories were evaluated. The results showed that altitude was the most important factor affecting the variation in the microbial community in the Tibetan population, and the change in altitude promoted the succession of the gut microbial community. In the process of migration from high altitudes to the plain, the gut microbial composition of late immigrants was similar to that of plateau aborigines, while that of early immigrants was similar to that of plain aborigines. Migration to Tibet is related to the loss of indigenous gut microbial community species. In addition, from low altitude to high altitude, the similarity of the microbial community with the high-altitude population increased with the reproduction of offspring after marriage. Changes in these microbials will affect the metabolism, disease incidence and cell function of the Tibetan population. The other two sets (AGP and Z208) of altitude data also showed the impact of altitude on the microbial community.Conclusions: This is the first large-scale study on the factors influencing the gut microflora in a Tibetan population. Our study confirmed that altitude change is the most important factor affecting the distribution of the microflora in the Tibetan population and provided abundant and unique data to explore the interaction of impact parameter-gut microbiome-host function and disease.

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“…Prevotella mainly participates in the metabolism of carbohydrates and plant proteins as well as short-chain fatty acid production [39]. Many Lachnospira strains produce butyrate, which plays a crucial role in the maintenance of human gut health [40]. These bacteria produce short-chain fatty acids, which can act as anti-in ammatory agents [40].…”

Section: Discussionmentioning

confidence: 99%

“…Many Lachnospira strains produce butyrate, which plays a crucial role in the maintenance of human gut health [40]. These bacteria produce short-chain fatty acids, which can act as anti-in ammatory agents [40]. It may explain how Tibetans with a low dietary ber intake maintain gut health.…”

Section: Discussionmentioning

confidence: 99%

Succession of the Gut Microbiome in the Tibetan Population of Minjiang River Basin

Li¹,

Sun²,

Mo³

et al. 2020

Preprint

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Background: Tibetans are one of the oldest ethnic groups in China and South Asia. Tibetan has a unique lifestyle and a long history, which leads to the particularity of their gut microflora in composition and function. Different from the Tibetan population on the Qinghai-Tibet Plateau, Tibetans in Minjiang River Basin have gradually increased their migration to Chengdu Plain in recent years. Based on the analysis of 1059 Tibetans in the Minjiang River Basin at an altitude of 500-4001m, we found that the dominant phylum of Tibetan population is Bacteroidea and Firmicum, and the main genera are Prevotella and Bacteroides. These findings reflect the characteristics of Tibetan population. Results: In order to further study the factors affecting gut microbial composition of Tibetan population, 115 total parameters of 7 categories were evaluated. The results showed that altitude was the most important factor affecting the variation of microbial community in Tibetan population, and the change of altitude promoted the succession of gut microbial community. In the process of migration from high altitude to plain, the intestinal microbial composition of late immigrants was similar to that of plateau aborigines, while that of early immigrants was similar to that of plain aborigines. Migration to Tibet is related to the loss of indigenous gut microbial community species. In addition, from low altitude to high altitude, the similarity of microbial community with high altitude population increased with the reproduction of offspring after marriage. And the change of these flora will affect the metabolism, disease and cell function of Tibetan population. The other two sets (AGP and Z208) of altitude data also show the impact of altitude on the microbial community. Conclusions: This is the first large-scale study on the influencing factors of gut microflora in Tibetan population. Our study confirmed that altitude change is the most important factor affecting the distribution of Tibetan population flora, and provided abundant and unique data to explore the interaction of impact parameter-gut microbiome-host function and disease.

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Growth and pectate-lyase activity of the ruminal bacterium Lachnospira multiparus in the presence of short-chain organic acids

Cited by 6 publications

References 27 publications

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

Succession of the Gut Microbiome in the Tibetan Population of the Minjiang River Basin

Succession of the Gut Microbiome in the Tibetan Population of Minjiang River Basin

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