Growth Characteristics of Chikungunya Virus Isolate from Indonesia in Various Human Cell Lines in vitro

Chikungunya (CHIK) is a reemerging arboviral disease caused by chikungunya virus (CHIKV) infection. The disease is clinically hallmarked by prolonged debilitating joint pain. Currently, there is no specific antiviral medication nor commercial vaccine available for treatment of the disease, which makes the discovery or development of specific anti-CHIKV compounds a priority. Ginger (Zingiber officinale Roscoe) is widely known for its various health benefits. The compound [6]-gingerol is the main active ingredient found in ginger. This study sought to determine the potential of [6]-gingerol antiviral activity against CHIKV infection using in vitro human hepatocyte HepG2 cells. The antiviral activity mechanism was investigated using direct virucidal and four indirect (pre-, post-, full-, and prevention) treatment assays. [6]-Gingerol showed weak virucidal activity but significant indirect antiviral activity against CHIKV through post- and full treatment with I C 50 of 0.038 mM and 0.031 mM, respectively, without showing cell cytotoxicity. The results indicated that [6]-gingerol inhibits CHIKV infection through suppression of viral replication. Together, this study confirms the potential use of [6]-gingerol for CHIK antiviral compound.

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[6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication

Hayati

Better

Denis

et al. 2021

BioMed Research International

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Growth Characteristics of Chikungunya Virus Isolate from Indonesia in Various Human Cell Lines in vitro

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References 29 publications

[6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication

[6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication

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