Growth Depression in Taurine-Depleted Infant Monkeys

Hayes, K. C.; Stephan, Zouhair F.; Sturman, John A.

doi:10.1093/jn/110.10.2058

Cited by 98 publications

(30 citation statements)

References 16 publications

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“…An animal study has indicated that taurine may be important for the growth of monkeys [6]. Hayes et al [5] have reported retinal degeneration associ ated wiih taurine deficiency in kittens.…”

Section: Discussionmentioning

confidence: 99%

Effect of Guanidinoethyl Sulfonate on Taurine Concentrations and Fetal Growth in Pregnant Rats

Ejiri¹,

Akahori²,

Kudo³

et al. 1987

Neonatology

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Guanidinoethyl sulfonate (GES), a transport antagonist of taurine, was given to pregnant rats from day 11 to 21 of gestation as a 1 % solution in drinking water. On day 21 of gestation in GES-treated pregnant rats, the concentration of taurine markedly decreased in the fetal whole body (54% of the control), the fetal liver (37%), the fetal whole brain (87%), the placenta (32%), the maternal liver (33%), the maternal whole brain (32%), and the maternal plasma (46 %). The wet weight of fetal whole body, liver and brain of fetus, and placenta also showed a significant drop. But there were no differences of weight gain, in the liver and brain weights of the mother of the control and GES-treated pregnant rats. The urinary excretion of taurine in pregnant rats treated with GES was much higher than that of the controls. These results suggest that the administration of GES to pregnant rats induces much urinary taurine excretion with a resulting decrease in the tissue taurine content and readily produces taurine-deficient fetal rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Guanidinoethyl Sulfonate on Taurine Concentrations and Fetal Growth in Pregnant Rats

Ejiri¹,

Akahori²,

Kudo³

et al. 1987

Neonatology

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“…Two species of infant primates (cebus and cynomolgus) were shown to depend on a dietary source of taurine ,for maximum growth measured by weight gain (40). However, these observations remain unexplained since dietary intake and absorption were not examined.…”

Section: Discussionmentioning

confidence: 99%

Effect of Taurine Supplements on Fat Absorption in Cystic Fibrosis

et al. 1985

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ABSTRACT. Patients with cystic fibrosis have an increased proportion of glycine conjugated bile acids with diminished tauroconjugates which could contribute to fat malabsorption. Twenty-two CF children with documented steatorrhea were supplemented with taurine capsules (30 mg/kg/day) and placebo during separate 6-month treatment periods. Alteration of the glycineltaurine conjugation pattern was verified in two patients who showed a predominance of tauroconjugates as a result of taurine suppiementation. On taurine, steatorrhea was reduced ( p < 0.05) by 17.6 rt 9.7% in 19 patients who completed the study as was the excretion of long-chain saturated fatty acids. There was no change in linoleic acid (C 18:2) excretion. In the 10 patients with a more severe degree of steatorrhea the decrease in fat loss approached 20% and a close relationship was found (r = 0.84, p < 0.01) between the extent of the fatty acid loss on placebo and the decrease of this loss on taurine. A linear relationship was found between the percentage decrease of individual fatty acids and their log solubility in water. No change was found in the daily excretion of bile acids, neutral sterols, and nitrogen. Fasting plasma fatty acids, cholesterol, and triglycerides were also unchanged. Monitoring of growth over the two 6-month periods revealed a marginal ( p < 0

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“…Recently there has been considerable interest in tau rine as a nutritionally important and perhaps essential compound [2,3,8,15,48,50,66]. It is clearly an essen tial nutrient for the cat and kitten, and its deficiency results in a number of neurological disorders, including visual dysfunction, retinal and tapetal degenerations, and impairment of normal cerebellar and visual cortex development [14,20,34,35,44,53,[56][57][58].…”

Section: Introductionmentioning

confidence: 99%

Laminar Analysis of the Number of Neurons, Astrocytes, Oligodendrocytes and Microglia in the Visual Cortex (Area 17) of 3-Month-Old Rhesus Monkeys Fed a Human Infant Soy-Protein Formula with or without Taurine Supplementation from Birth

et al. 1991

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The effect of taurine addition to a commercial (taurine-free) soy-protein formula on the development of the visual cortex has been examined in 3-month-old rhesus monkeys. The thickness, number of neurons, astrocytes, oligodendrocytes and microglia have been measured in the different laminae. There were no significant differences in cortical thickness, total number of neurons, astrocytes, oligodendrocytes, or microglia between the groups, but there were some significant differences in some laminae as well as some qualitative differences. The numerical density of neurons in layers IV-Cα and V-2 was significantly greater in the taurine-supplemented monkeys than in those fed the taurine-free formula; the numerical density of astrocytes in layer IV-A was significantly greater and in layer IV-Ca was significantly smaller in the taurine-supplemented monkeys than in those fed the taurine-free formula. A number of other measurements in the two groups approached significance. These differences indicate that there are developmental disadvantages in the visual cortex of rhesus monkeys raised on a taurine-free human infant formula in addition to those previously reported.

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Growth Depression in Taurine-Depleted Infant Monkeys

Cited by 98 publications

References 16 publications

Effect of Guanidinoethyl Sulfonate on Taurine Concentrations and Fetal Growth in Pregnant Rats

Effect of Guanidinoethyl Sulfonate on Taurine Concentrations and Fetal Growth in Pregnant Rats

Effect of Taurine Supplements on Fat Absorption in Cystic Fibrosis

Laminar Analysis of the Number of Neurons, Astrocytes, Oligodendrocytes and Microglia in the Visual Cortex (Area 17) of 3-Month-Old Rhesus Monkeys Fed a Human Infant Soy-Protein Formula with or without Taurine Supplementation from Birth

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