Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

Jy, Kim; St, Kim; Cho, Sung Won; Jung, Han‐Sung; Park, KT; Hk, Son

doi:10.1111/j.1601-0825.2007.01435.x

Cited by 36 publications

(24 citation statements)

References 44 publications

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“…This finding coincides with that of our previous study (Kim et al, 2008), in which we concluded that weight differences may be the result of reduced muscle tonicity and mass induced by bilateral BTX-A injection.…”

Section: Overall Body Weights and Amounts Of Pellets Consumedsupporting

confidence: 93%

“…The lack of statistical differences for these two measurements was presumably due to observational errors stemming from the difficulty in locating the condylar point and the tip of the coronoid process. Our finding of statistically smaller dimensions in Group 3 coincides with that of a previous study (Kim et al, 2008). In previous studies, histological findings revealed an inhibitory action of BTX-A due to induced apoptosis at the proliferation stage of the reserve zone of condylar cartilage in developing mandibles.…”

Section: Changes In Mandibular Measurementssupporting

confidence: 91%

“…Thus, the induction of muscle hypofunction may influence facial growth. Recent studies using BTX-A (Kim et al, 2008;Tsai et al, 2010) have supported the theory. These studies included animal experiments designed to investigate changes in masticatory muscle function due to the effects of BTX-A on skeletal development.…”

Section: Introductionmentioning

confidence: 77%

“…In a study of rat mandibles injected with BTX-A in bilateral masseter muscles, mandibular dimensions were reduced compared with those of saline-injected rats (Kim et al, 2008). However, a limitation of that study was that the comparison was made between different individuals.…”

Section: Introductionmentioning

confidence: 98%

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Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

Park

Kim

2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To evaluate the effects of botulinum toxin type A (BTX-A) on mandible skeletal development by inducing muscle hypofunction. Methods: Four-week-old Sprague-Dawley rats (n=60) were divided into three groups: Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A (the contralateral side was injected with saline); and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side (Group 2-1), whereas the BTX-A-injected side was designated the experimental side (Group 2-2). After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results: In the unilateral group, the experimental side (Group 2-2) had reduced dimensions for all mandible measurements compared with the control side (Group 2-1), suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions: Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.

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Section: Overall Body Weights and Amounts Of Pellets Consumedsupporting

confidence: 93%

Section: Changes In Mandibular Measurementssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

Park

Kim

2015

J. Zhejiang Univ. Sci. B

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“…Matic et al (2007) e Kim et al (2008) relatam que paralisia do músculo masseter resulta em atrofia do músculo e subsequentemente retardo do crescimento da mandíbula.…”

Section: Introductionunclassified

Efeito do β-hidroxi-β-metilbutirato sobre os músculos da mastigação e desenvolvimento e crescimento craniofacial de ratos

Daré¹

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Efeito do β-hidroxi-β-metilbutirato sobre os músculos da mastigação e desenvolvimento e crescimento craniofacial de ratos BAURU 2013 LETICIA ROSSI DARÉEfeito do β-hidroxi-β-metilbutirato sobre os músculos da mastigação e desenvolvimento e crescimento craniofacial de ratos Autorizo, exclusivamente para fins acadêmicos e científicos, a reprodução total ou parcial desta dissertação/tese, por processos fotocopiadores e outros meios eletrônicos. Meus irmãos, Fernanda e Danilo, pela eterna cumplicidade, amor e confiança que tenho em vocês. Vocês são exemplos de competência e honestidade pra mim. Obrigada por estarem sempre por perto.Meu noivo, Daniel pelo inestimável apoio e incentivo na realização deste trabalho. Obrigada por toda ajuda, companheirismo, paciência, carinho, amizade e lealdade. Você é um exemplo de coragem e competência. Amo muito vocês! AGRADECIMENTOSPrimeiramente agradeço à Deus por ter guiado meus passos e por nunca me deixar sozinha.Ao Prof. Dr. Jesus Carlos Andreo, agradeço pela confiança depositada em mim desde os primeiros anos de estágio até os dias de hoje. A convivência com uma pessoa tão sábia, humilde e de um caráter apreciável foi um privilegio pra mim.Ensinamentos profissionais e pessoais que vou levar por toda vida.Ao Prof. Dr. Antonio de Castro Rodrigues por todo apoio, ensinamentos, amizade e incentivo.Ao Prof. Dr. Rogério Leone Buchaim pelo incentivo, confiança e amizade durante todos os dias.Ao Prof. José Roberto Lauris pela colaboração nas análises estatísticas.Ao amigo e pós-graduando Geraldo Marco Rosa Junior, por toda confiança desde que me apresentou à anatomia, pela lealdade e amizade verdadeira. Por toda ajuda profissional e pelo companheirismo de todo dia. À Tia Maricó, Tio Adilson, e meu cunhado Alessandro Morelli e demais familiares pelo enorme apoio. Agradeço pela confiança e incentivo que me deram durante todo período do mestrado. Sempre me apoiando e acreditando em mim.Aos amigos conquistados antes e durante a realização deste trabalho, Cleuber Bueno, Jessica Gonçalves, Karina Puzipe e Luis Henrique Moraes.Agradeço pela imensa amizade criada em um ambiente profissional, mas que quero levar sempre comigo na minha vida pessoal. ABSTRACTNowadays is increasing the number of people who use nutritional supplements in order to achieve better results in their sports, fat loss, muscle gains, or the plasticity of the body. This deserves attention because very little is known about the safety or efficacy of such products, and only 14% of users seeking guidance with a health professional regarding the use of these substances. Of the more than 200 supplements that promise these effects only the HMB and creatine supplementation produce the promised effects, and the Olympic Committee qualifies the use of HMB as legal. While the literature shows benefits in the use of HMB supplementation, there is little information on its effect on muscle fibers morphophysiology as, for example, the profile and the area histoenzimológico of different types of muscle fibers. Based on this information, ...

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Future Perspectives of Botulinum Toxin Application in Dentistry

Etemad‐Moghadam

2020

Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

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Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible

Abstract: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.

Cited by 36 publications

References 44 publications

Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

Efeito do β-hidroxi-β-metilbutirato sobre os músculos da mastigação e desenvolvimento e crescimento craniofacial de ratos

Future Perspectives of Botulinum Toxin Application in Dentistry

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