Growth Factor Delivery Using a Collagen Membrane for Bone Tissue Regeneration

Abstract

The use of biomaterials and bioactive agents has shown promise in bone defect repair, leading to the development of strategies for bone regeneration. Various artificial membranes, especially collagen membranes (CMs) that are widely used for periodontal therapy and provide an extracellular matrix-simulating environment, play a significant role in promoting bone regeneration. In addition, numerous growth factors (GFs) have been used as clinical applications in regenerative therapy. However, it has been established that the unregulated administration of these factors may not work to their full regenerative potential and could also trigger unfavorable side effects. The utilization of these factors in clinical settings is still restricted due to the lack of effective delivery systems and biomaterial carriers. Hence, considering the efficiency of bone regeneration, both spaces maintained using CMs and GFs can synergistically create successful outcomes in bone tissue engineering. Therefore, recent studies have demonstrated a significant interest in the potential of combining CMs and GFs to effectively promote bone repair. This approach holds great promise and has become a focal point in our research. The purpose of this review is to highlight the role of CMs containing GFs in the regeneration of bone tissue, and to discuss their use in preclinical animal models of regeneration. Additionally, the review addresses potential concerns and suggests future research directions for growth factor therapy in the field of regenerative science.

Cellular Signaling for Dental Physiological Functions

“…Collagen-based materials such as membranes, sponges, matrices, hydrogels, and composite scaffolds have been extensively used in in vivo studies to facilitate bone tissue regeneration. Takayama et al summarized growth factor (GF) delivery systems that use collagen membranes (CMs) for bone tissue regeneration [ 29 ]. Biomaterials and bioactive agents may play a potential role in bone defect repair; thus, they are being explored for developing bone regeneration strategies.…”

“…Takayama et al highlighted the role of GF-containing CMs in bone tissue regeneration and discussed the use of these CMs in preclinical animal models of regeneration. Additionally, authors addressed the potential concerns and suggested future research directions for GF therapy in regenerative science [ 29 ].…”