Growth Factors and Cell Homing in Dental Tissue Regeneration

Duncan, Henry F.; Kobayashi, Yoshifumi; Shimizu, Emi

doi:10.1007/s40496-018-0194-y

Cited by 46 publications

(49 citation statements)

References 108 publications

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“…Although the scope of RE is presently limited to the management of immature nonvital permanent teeth. [ 3 ] Research is underway to attain pulp regeneration in mature teeth,[ 22 ] which, if achieved, would revolutionize the field of Endodontics and be beneficial to patients and the public health sector. “Seal Bio” a nonobturation technique was among the initial efforts to practice regeneration in mature permanent teeth.…”

Section: Discussionmentioning

confidence: 99%

India's contribution to regenerative endodontics: A bibliometric analysis

et al. 2020

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Regenerative endodontics (RE) is a dynamic field with widespread global impact. The aim of this bibliometric analysis is to highlight India's contribution in the field. Electronic search was performed in PubMed and Web of Science database till December 2019 using the search terms “Dental pulp regeneration,” “Pulp revascularisation,” “Revitalisation,” “Regenerative endodontic,” and their permutation. Articles of Indian authors with affiliation to Indian institutes were included. The following data were extracted: first author, institute and state of affiliation, year and journal of publication, study design, level of evidence (LOE), and number of citations. A total of 76 articles (case reports [ n = 29, 38.15%], review [ n = 25, 32.8%]) were published between 2008 and 2019. Majority (42.6%) were categorized as LOE 4. 7.4% articles were in LOE1 category. Eight percent articles had citations above 100 (highest cited-354 citations). The average yearly growth rate between 2011 and 2019 was 33.28% and highest number of publications was in the year 2015. The south zone had the maximum publications. At an institutional level, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, had the maximum publications. Journal of Conservative Dentistry published the highest number of articles. India contributed 7.6% of the global PubMed indexed publications and reported 22% of clinical trials. This analysis reveals increasing trend of research in RE in India. However, it highlights the need to generate articles with higher LOE by conducting quality multicenter trials and promote national and international collaborations.

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Section: Discussionmentioning

confidence: 99%

India's contribution to regenerative endodontics: A bibliometric analysis

et al. 2020

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“…They inferred that the vasculature could provide support for cell survival and differentiation, and thus long-term dentinogenesis in dentin-pulp complex [3,11]. In addition, real-time PCR analysis revealed that the expression of OCT4 gene was lower in the inflamed pulp; however, the expressions of other embryonic and dentinogenic genes in the inflamed pulp were similar to those in the normal pulp.…”

Section: Discussionmentioning

confidence: 99%

Localization of pulp stem cells in chronic pulpitis

Chun

Tong

et al. 2020

Preprint

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Background: Our study aimed to observe the distribution of stem cells in chronic pulpitis and to investigate the expression of specific molecules. Methods: Extracted third molar teeth were collected and divided into two groups. Experiment group was from patients with previous history of spontaneous pain and diagnosed as having chronic pulpitis. Noncarious third molars were used as control group. Dental pulp tissues were collected from these two groups. Real-time RT-PCR test was used to detect the expression of several embryonic and dentinogenic genes in dental pulp. The expression of the mesenchymal cell markers (STRO-1, CD146) and stromal cell-derived factor 1α (SDF-1α)/CXC chemokine receptor 4 (CXCR4) proteins were examined by immunohistochemical and triple immunofluorescence analysis. Results: ThemRNA levels of most embryonic and dentinogenic genes were not statistically different (p > 0.05) between the two groups. Immunohistochemical analysis revealed that in inflamed pulp, STRO-1- and CD146-positive cells mainly reside in two specific niches, both adjacent to inflammatory sites: one in the pulp core, and another in odontoblast layer. In contrast, fewer STRO-1- and CD146- positive cells appeared in the vicinity of the root apex. SDF-1α- and CXCR4-positive cells increased in zone I and II, and decreased in zone III, showing a significant correlation with STRO-1. Triple immunofluorescence analysis indicated that most STRO-1-positive cells overlapped with SDF-1α- and CXCR4-positive cells around the perivascular areas near the inflammatory site. Conclusions: This study gave a direct observation of stem cells distribution in chronic pulpitis for the first time and implies the important role of SDF-1α/CXCR4signaling in stem cells-based therapies for reparative dentinogenesis.

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“…It is established that dental tissue repair processes can be signaled by bioactive molecules released from the dentin by cariesderived bacterial acids or restorative agents, such as calcium hydroxide and calcium silicates. Because of the biphasic signaling that occurs in response to molecules, such as TNFa and TGF-b1, along with ROS and bacterial components, it is apparent that a fine balance exists between pathogenesis and dental tissue repair [22][23][24][25][26][27][28] .…”

Section: Significancementioning

confidence: 99%