Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

Danilenko, Dimitry M.; Ring, Brian D.; Pierce, Glenn F.

doi:10.1016/1357-4310(96)10045-9

Cited by 114 publications

(77 citation statements)

References 28 publications

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“…To promote hair growth and initiate anagen, it is essential that expression of factors maintaining anagen is increased, such as IGF-1, basic fibroblast growth factor (bFGF), KGF, and VEGF, while decreasing expression of cytokines promote apoptosis, such as TGF-β, and IL-1. 32,33) VEGF plays a central role in promoting angiogenesis as well as influencing diverse cell functions including cell survival, proliferation, and generation of nitric oxide and prostacyclin.…”

Section: Discussionmentioning

confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

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Section: Discussionmentioning

confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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“…The considerably longer duration (5-6 weeks) of second telogen phase before onset of third anagen phase provides an unambiguous demonstration of anagen induction by AdShh. To date, a number of growth factors have been implicated in hair follicle growth and progression through the hair cycle (7,8), but the key signaling molecules responsible for unleashing the coordinated cascade of factors mediating the transition from telogen to anagen remain to be identified. The relevance of Shh to hair development has been suggested in both gain-and lossof-function models wherein modified Shh expression exists throughout embryonic development.…”

Section: Figurementioning

confidence: 99%

Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

Satô¹,

Leopold²,

Crystal³

1999

J. Clin. Invest.

232

168

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“…lA, C), while KGFR is expressed only by epithelial tissues, such as epidermis and intestinal epithelium, generally in very close proximity to cells that express KGF (Fig. 1B, D) (1,5,15). BIOLOGIC …”

Section: Introductionmentioning

confidence: 95%

Preclinical and Early Clinical Development of Keratinocyte Growth Factor, an Epithelial- Specific Tissue Growth Factor

Danilenko

1999

Toxicol Pathol

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Keratinocyte growth factor (KGF) is a 28-kDa heparin-binding member of the fibroblast growth factor (FGF) family ( mucositis. Several dose-and time-variable studies were conducted in normal rhesus macaques to determine the lowest dose and shortest duration of rHuKGF administration required to induce oral mucosal proliferation without other significant systemic effects. Numerous studies were also conducted in murine models of chemotherapy-induced mucositis to fine-tune the dosing schedule. These studies showed that 2-3 days of rHuKGF administration were sufficient to induce significant oral mucosal proliferation and to protect against gastrointestinal mucositis when administered prior to the initiation of chemotherapy. The results from these models were used to design a phase I study in normal human volunteers to evaluate the safety of rHuKGF and its ability to induce oral mucosal proliferation. rHuKGF was well tolerated and induced a significant increase in markers of oral mucosal proliferation following 3 days of administration at the highest doses. Phase I/II studies to evaluate the safety and efficacy of rHuKGF in the prevention of chemotherapy-induced mucositis are currently in progress.

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Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

Cited by 114 publications

References 28 publications

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

Preclinical and Early Clinical Development of Keratinocyte Growth Factor, an Epithelial- Specific Tissue Growth Factor

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