Growth factors and experimental arterial grafts

Sterpetti, Antonio V.; Lepidi, Sandro; Borrelli, Valeria; Marzo, Luca di; Sapienza, Paolo; Cucina, Alessandra; Ventura, M

doi:10.1016/j.jvs.2015.07.091

Cited by 13 publications

(8 citation statements)

References 26 publications

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“…In macrophage depletion studies, a reduction in inflammatory cytokines, as well as neointima formation, has been observed previously. [25][26][27] In our study, the postoperative plasma level of IL-6 and TNF-α were significantly higher for the first year in patients who underwent PTA with selective stent positioning of the SFA when compared with those who underwent vein revascularisation procedures. However, IL-6 and TNF-α were positively related to impending reconstructive surgery failure.…”

Section: Discussionmentioning

confidence: 44%

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Sapienza

Mingoli

Borrelli

et al. 2019

International Wound Journal

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Prodromal signs of a non-healing wound after revascularisation, which might be strictly linked with impending failure of vascular reconstructions, are associated with an inflammatory response mediated by several circulating adhesion molecules, extracellular endopeptidases, and cytokines. The aim of our study was to investigate the role of selected plasma biomarkers in the prediction of both wound healing and failure of infrapopliteal vein graft or percutaneous trans-luminal angioplasty (PTA) with selective stent positioning of the superficial femoral artery (SFA) in a population affected with critical limb ischaemia. A total of 68 patients who underwent either surgical or endovascular revascularisation of the inferior limb with autologous saphenous vein infrapopliteal bypass or PTA and selective stenting of the SFA were enrolled in our study. Patients were divided into two groups according to treatment: 41 patients were included in Group 1 (open surgery) and 27 in Group 2 (endovascular procedure). Plasma and blood samples were collected on the morning of surgery and every 6 months thereafter for up to 2 years of follow-up or until an occlusion occurred of either the vein bypass graft or the vessel treated endovascularly. Fifteen age-matched healthy male volunteers were considered a reference for biological parameters. Vascular cell adhesion molecule 1 [VCAM-1]/CD106, inter-cellular adhesion molecule-1 [ICAM-1]/CD54), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and metalloproteinases (MMP)-2 and -9 plasma levels were measured with enzyme-linked immunosorbent assay (ELISA) kits. The mean observed time to heal of 54 wounds was 13 ± 4 months, with no statistically significant differences among the groups. The healing failure of the remaining wounds was strictly related to an unsuccessful open (n = 12) or endovascular (n = 8) treatment. The 2-year primary patency rate was 65% (SE = .09) in Group 1 and 52% (SE = .1) in Group 2. When compared with mean concentration values of Group 1, VCAM-1 and ICAM-1 were always significantly higher during follow-up in patients of Group 2 (P < .05). Furthermore, in the same group, IL-6 and tumour necrosis factor alpha (TNF-α) were found to be significantly higher at 6-and 12-month (P < .05) when compared with surgically treated patients. Cox regression analysis showed that

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Section: Discussionmentioning

confidence: 44%

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Sapienza

Mingoli

Borrelli

et al. 2019

International Wound Journal

Self Cite

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“…In the venous flow, the concentration of growth factors is much reduced. In vitro studies show that endothelial and smooth muscle cells, not exposed to any shear stress, have a much higher proliferation rate in the presence of the same concentrations of growth factors, compared with cells subjected to shear stress [ 75 , 76 ]. Thus, the simultaneous presence of low and high shear stress, as present in turbulence, facilitates the action of growth factors; growth factors production is increased in areas of high shear stress, and they can act, through a paracrine mechanism, in the neighbour cells, located in the low shear stress zone, where they can easily proliferate.…”

Section: Sources Of Inflammatory Cytokinesmentioning

confidence: 99%

Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications

Sterpetti

2020

Curr Atheroscler Rep

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Purpose of the Review Inflammatory cytokines play a major role in atherosclerotic plaque progression. This review summarizes the rationale for personalized anti-inflammatory therapy. Recent Findings Systemic inflammatory parameters may be used to follow the clinical outcome in primary and secondary prevention. Medical therapy, both in patients with stable cardiovascular disease, or with acute events, may be tailored taking into consideration the level and course of systemic inflammatory mediators. There is significant space for improvement in primary prevention and in the treatment of patients who have suffered from severe cardiovascular events, paying attention to not only blood pressure and cholesterol levels but also including inflammatory parameters in our clinical analysis. Summary The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that regulate the relationship between inflammation and atherosclerosis, new, more effective and specific anti-inflammatory treatment may become available.

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“…These actions determine increasing size of the plaque transforming a simple plaque in a ''dangerous'' unstable plaque. 3,4 An aggressive antiplatelet and lipid-lowering therapy has been shown to improve patency rates of coronary vein grafts. It is possible that those therapies could have a major role in reducing the production and effect of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…These actions determine increasing size of the plaque transforming a simple plaque in a “dangerous” unstable plaque. 3 , 4 …”

Section: Discussionmentioning

confidence: 99%

Inflammatory cytokines and experimental arterial and vein grafts

et al. 2020

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Ten years after surgery, only 40% of the saphenous coronary artery bypass grafts have a normal appearance. 1 Myointimal hyperplasia and atherosclerosis are unusual in the internal thoracic artery. A systematic review has shown better patency rates for the radial artery. 2 The aim of our study was to determine the release of several inflammatory cytokines from experimental arterial and vein grafts. Increased production of inflammatory cytokines by vein grafts might lead to higher incidence of occlusive changes.

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Growth factors and experimental arterial grafts

Abstract: Agents able to neutralize this increased production of growth factors, either directly or by competition with their receptors, can prevent MH formation.

Cited by 13 publications

References 26 publications

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Different inflammatory cytokines release after open and endovascular reconstructions influences wound healing

Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications

Inflammatory cytokines and experimental arterial and vein grafts

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