Growth factors and stroke

Greenberg, David A.; Jin, Kunlin

doi:10.1016/j.nurx.2006.08.003

Cited by 32 publications

(23 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding of a neurovascular niche for neurogenesis after stroke is supported by the many growth factors or pharmacological agents that appear capable of inducing both of these processes together, such as VEGF, erythropoietin, FGF2, statins and phosphodieseterase type 5 inhibitors. [75][76][77][78] These data linking angiogenic blood vessels with newly born immature neurons in peri-infarct cortex appear at odds with the reported association of immature neurons and astrocytes in the ischemic striatum. 69 As reviewed below, the differences in association of newly born immature neurons in stroke predominantly with astrocytes in ischemic striatum and with angiogenic blood vessels in peri-infarct cortex likely relates to important, and often overlooked, differences in the stroke models used in neural repair studies.…”

Section: Poststroke Neurogenesismentioning

confidence: 97%

Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch

Carmichael

2008

Stroke

105

View full text Add to dashboard Cite

Background and Purpose-This review will focus on the emerging principles of neural repair after stroke, and on the overlap between cellular mechanisms of neural repair in stroke and clinical principles of recovery and rehabilitation. Summary of Review-Stroke induces axonal sprouting and neurogenesis. Axonal sprouting occurs in tissue adjacent to the stroke and its connected cortical areas, and from sites that are contralateral to the infarct. Neurogenesis produces newly born immature neurons in peri-infarct striatum and cortex. Stimulation of both axonal sprouting and neurogenesis is associated with improved recovery in animal models of stroke. A unique cellular environment in the poststroke brain supports neural repair: an association of angiogenic and remodeling blood vessels with newly born immature neurons in a neurovasclar niche. Controversies in the field of neural repair after stroke persist, and relate to the locations of axonal sprouting in animal models of stroke and how these correlate to patterns of human remapping and recovery, and to the different models of stroke used in studies of neurogenesis. Conclusions-On a cellular level, the phenomenology of neural repair after stroke has been defined and unique regenerative environments in the poststroke brain identified. As the field moves toward specific studies of causal mechanisms in poststroke repair, it will need to maintain a perspective of the animal models suited to the study of neural repair after stroke as they relate to the patterns of recovery in humans in this disease.

show abstract

Section: Poststroke Neurogenesismentioning

confidence: 97%

Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch

Carmichael

2008

Stroke

105

View full text Add to dashboard Cite

show abstract

“…Neural stem cells enact cell proliferation and recruitment through the production and secretion of growth factors that are correlated with recovery following ischemia, including endothelial growth factor (EGF) and FGF-2 (Greenberg and Jin, 2006;Vishwakarma et al, 2014). Some growth factors such as VEGF have a short-term impact, having demonstrated an increase in vascularity of infarcted tissue following stroke (Greenberg and Jin, 2006), and presenting upregulation in rat middle cerebral artery occlusion (MCAO) models after 3 h (Marti et al, 2000).…”

Section: Goal Of Tissue Engineering Strategiesmentioning

confidence: 99%

“…Some growth factors such as VEGF have a short-term impact, having demonstrated an increase in vascularity of infarcted tissue following stroke (Greenberg and Jin, 2006), and presenting upregulation in rat middle cerebral artery occlusion (MCAO) models after 3 h (Marti et al, 2000). Both insulin-growth factor-1 (IGF-1) and BDNF have also demonstrated promising results as acute therapies, beginning administration after 30 and 15 min post MCAO, respectively, and primarily attributed to reduction in infarct volume (Greenberg and Jin, 2006). Growth factor presentation in various forms is integral to promoting repair and functional recovery following stroke.…”

Section: Goal Of Tissue Engineering Strategiesmentioning

confidence: 99%

Stroke Repair via Biomimicry of the Subventricular Zone

Matta

Gonzalez

2018

Front. Mater.

View full text Add to dashboard Cite

Stroke is among the leading causes of death and disability worldwide, 85% of which are ischemic. Current stroke therapies are limited by a narrow effective therapeutic time and fail to effectively complete the recovery of the damaged area. Magnetic resonance imaging of the subventricular zone (SVZ) following infarct/stroke has allowed visualization of new axonal connections and projections being formed, while new immature neurons migrate from the SVZ to the peri-infarct area. Such studies suggest that the SVZ is a primary source of regenerative cells for the repair and regeneration of stroke-damaged neurons and tissue. Therefore, the development of tissue engineered scaffolds that serve as a bioreplicative SVZ niche would support the survival of multiple cell types that reside in the SVZ. Essential to replication of the human SVZ microenvironment is the establishment of microvasculature that regulates both the healthy and stroke-injured blood-brain barrier, which is dysregulated poststroke. In order to reproduce this niche, understanding how cells interact in this environment is critical, in particular neural stem cells, endothelial cells, pericytes, ependymal cells, and microglia. Remodeling and repair of the matrix-rich SVZ niche by endogenous reparative mechanisms may then support functional recovery when enhanced by an artificial niche that supports the survival and proliferation of migrating vascular and neuronal cells. Critical considerations to mimic this area include an understanding of resident cell types, delivery method, and the use of biocompatible materials. Controlling stem cell survival, differentiation, and migration are key factors to consider when transplanting stem cells. Here, we discuss the role of the SVZ architecture and resident cells in the promotion and enhancement of endogenous repair mechanisms. We elucidate the interplay between the extracellular matrix composition and cell interactions prior to and following stroke. Finally, we review current cell and neuronal niche biomimetic materials that allow for a tissue-engineered approach in order to promote structural and functional restoration of neural circuitry. By creating an artificial mimetic SVZ, tissue engineers can strive to facilitate tissue regeneration and functional recovery.

show abstract

“…Поэтому ростовые факторы и металлопротеина-зы, продуцируемые макрофагами, нейронами, астроцитами, олигодендроцитами и эндотели-альными клетками, обеспечивают процессы вос-становления и ремоделирования поврежденной нервной ткани [15,40].…”

Section: адаптивный иммунный ответunclassified

Immunopathogenetic Aspects of Ischemic Stroke

Черных¹,

Shevela²,

Morozov³

et al. 2018

Med. immunol.

View full text Add to dashboard Cite

Адрес для переписки:Черных Елена Рэмовна ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии» 630099, Россия, г. Новосибирск, Ядринцевская ул., 14. Тел.: 8 (383) 236-03-29. Факс: 8 (383) 222-70-28. Е-mail: ct_lab@mail.ru Address for correspondence:Chernykh Elena R. Research Institute of Fundamental and Clinical Immunology 630099, Russian Federation, Novosibirsk, Yadrintsevskaya str., juli_k@bk.ru Образец цитирования: Е.Р. Черных, Е.Я. Шевела, С.А. Морозов, А.А. Останин «Иммунопатогенетические аспекты ишемического инсульта» // Медицинская иммунология, 2018. Т. 20, № 1. С. 19-34. doi: 10.15789/1563-0625-2018-1-19-34 © Черных Е.Р. и соавт., 2018 For citation: E.R. Chernykh, E.Ya. Shevela, S.A. Morozov, A.A. Ostanin "Immunopathogenetic aspects of ischemic stroke", Medical Immunology (Russia)/Meditsinskaya Immunologiya, 2018, Vol. 20, no. 1, pp. 19-34. doi: 10.15789/1563-0625-2018-1-19-34 DOI: 10.15789/1563-0625-2018 ИММУНОПАТОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ИШЕМИЧЕСКОГО ИНСУЛЬТА Черных Е.Р., Шевела Е.Я., Морозов С.А., Останин А.А. ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии», г. Новосибирск, РоссияРезюме. Иммунная система играет ключевую роль в патогенезе ишемического инсульта. Ишеми-ческое поражение головного мозга приводит к разрушению клеток и белков внеклеточного матрикса и высвобождению молекул «опасности», которые вызывают быструю активацию врожденного имму-нитета и индуцируют реакции адаптивного иммунитета с аутоиммунной направленностью. Клетки врожденного иммунитета ответственны за элиминацию клеточного и внеклеточного детрита и ткане-вую репарацию, однако также вовлечены в запуск постишемического воспаления, вызывающего по-вреждение мозговой ткани. Развивающиеся через несколько дней реакции адаптивного иммунитета, направленные против собственных антигенов, не имеют отношения к повреждению нервной ткани в остром периоде. Клетки адаптивного иммунитета способны регулировать активность микроглии и стимулировать процессы восстановления в центральной нервной системе. Тем не менее длитель-ная персистенция сенсибилизированных к мозгоспецифическим антигенам лимфоцитов может быть причастна к атрофии коры головного мозга и развитию деменции в отдаленном периоде инсульта. Иммунный ответ на ишемическое поражение мозга имеет как локальные, так и системные прояв-ления. При этом, в отличие от продолжительного интрацеребрального воспаления в зоне инфаркта и окружающих тканях, системный воспалительный ответ на периферии быстро сменяется развити-ем иммуносупрессии, что подтверждается лимфопенией, атрофией лимфоидных органов и дефектом функциональной активности иммунных клеток. Иммуносупрессия во многом обусловлена актива-цией симпатоадреналовой системы и направлена на ограничение воспаления и аутоиммунных реак-ций. Тем не менее, избыточные проявления иммуносупрессии приводят к развитию инфекционных осложнений, часто являющихся причиной летального исхода, а также могут негативно сказываться на эффективности репаративных процессов. В настоя...

show abstract

Growth factors and stroke

Cited by 32 publications

References 62 publications

Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch

Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch

Stroke Repair via Biomimicry of the Subventricular Zone

Immunopathogenetic Aspects of Ischemic Stroke

Contact Info

Product

Resources

About