Growth factors improve muscle healing in vivo

Ménétrey, Jacques; Kasemkijwattana, Channarong; Day, Charles S.; Bosch, Patrick; Vogt, Michael; Fu, Freddie H.; Moreland, Morey S.; Huard, Johnny

doi:10.1302/0301-620x.82b1.8954

Cited by 291 publications

(165 citation statements)

References 42 publications

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“…Both IGF-1 and -2 are induced by muscle injury (51), and these factors can stimulate the proliferation and differentiation of myoblasts (11,52). The administration of IGF-1 will promote the regeneration of injured muscle (53)(54)(55). IGF-1 will also promote myofiber hypertrophy, and transgenic mice that overexpress this growth factor exhibit increased muscle mass (56 -58).…”

Section: Discussionmentioning

confidence: 99%

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

Zeng

Akasaki

Sato

et al. 2010

Journal of Biological Chemistry

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The insulin-like family of factors are involved in the regulation of a variety of physiological processes, but the function of the family member termed insulin-like 6 (Insl6) in skeletal muscle has not been reported. We show that Insl6 is a myokine that is up-regulated in skeletal muscle downstream of Akt signaling and in regenerating muscle in response to cardiotoxin (CTX)-induced injury. In the CTX injury model, myofiber regeneration was improved by the intramuscular or systemic delivery of an adenovirus expressing Insl6. Skeletal muscle-specific Insl6 transgenic mice exhibited normal muscle mass under basal conditions but elevated satellite cell activation and enhanced muscle regeneration in response to CTX injury. The Insl6-mediated regenerative response was associated with reductions in muscle cell apoptosis and reduced serum levels of creatine kinase M. Overexpression of Insl6 stimulated proliferation and reduced apoptosis in cultured myogenic cells. Conversely, knockdown of Insl6 reduced proliferation and increased apoptosis. These data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor.

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Section: Discussionmentioning

confidence: 99%

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

Zeng

Akasaki

Sato

et al. 2010

Journal of Biological Chemistry

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“…In vitro studies have shown the ability of IGF-1 to promote the proliferation of satellite cells and to alter the expression of myogenic factors (Charge and Rudnicki 2004;Chakravarthy et al 2001;Hsu et al 1997;Philippou et al 2007). In vivo systemic injection of IGF-1 results in skeletal muscle hypertrophy, whereas direct injection of IGF-1 into muscle enhances muscle regeneration (Hsu et al 1997;Kasemkijwattana et al 1998;Menetrey et al 2000;Sato et al 2003). HGF is the primary regulator of satellite cell proliferation, with HGF expression increasing in proportion to the degree of injury Tatsumi 2010;Tatsumi et al 2002).…”

Section: Control Of the Regenerative Microenvironmentmentioning

confidence: 99%

Regeneration of skeletal muscle

2011

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Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options for volumetric muscle loss are available. Autologous muscle grafts or muscle transposition represent possible salvage procedures for the restoration of mass and function but these approaches have limited success and are plagued by associated donor site morbidity. Cell-based therapies are in their infancy and, to date, have largely focused on hereditary disorders such as Duchenne muscular dystrophy. An unequivocal need exists for regenerative medicine strategies that can enhance or induce de novo formation of functional skeletal muscle as a treatment for congenital absence or traumatic loss of tissue. In this review, the three stages of skeletal muscle regeneration and the potential pitfalls in the development of regenerative medicine strategies for the restoration of functional skeletal muscle in situ are discussed.

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“…They can occur through a variety of mechanisms, ranging from direct mechanical deformation (such as muscle laceration, strain, and contusion) to indirect damage related to ischemia and neurologic dysfunction [1][2]. Although muscle tissue can regenerate after injury, the process tends to be slow, often resulting in functional and structural muscle atrophy, contracture, pain, and reinjury [3][4].…”

Section: Introductionmentioning

confidence: 99%

Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion

Rodrigues

Assis²,

Fernandes³

et al. 2013

J Rehabil Res Dev

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Abstract-The aim of this study was to evaluate the effects of 660 nm low-level laser therapy (LLLT) on muscle regeneration after cryolesion in rat tibialis anterior muscle. Sixty-three Wistar rats were divided into a control group, 10 J/cm 2 lasertreated group, and 50 J/cm 2 laser-treated group. Each group formed three subgroups (n = 7 per group), and the animals were sacrificed 7, 14, or 21 d after lesion. Histopathological findings revealed a lower inflammatory process in the lasertreated groups after 7 d. After 14 d, irradiated animals at both fluences showed higher granulation tissue, new muscle fibers, and organized muscle structure. After 21 d, full tissue repair was observed in all groups. Moreover, irradiated animals at both fluences showed smaller necrosis area in the first experimental period evaluated. MyoD immunoexpression was observed in both treated groups 7 d postinjury. Myogenin immunoexpression was detected after 7 and 14 d. The higher fluence increased the number of blood vessels after 14 and 21 d. These results suggest that LLLT, at both fluences, positively affects injured skeletal muscle in rats, accelerating the muscle-regeneration process.

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Growth factors improve muscle healing in vivo

Cited by 291 publications

References 42 publications

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

Regeneration of skeletal muscle

Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion

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