Growth factors improve muscle healing in vivo

Menetrey, J.; Kasemkijwattana, C.; Day, C. S.; Bosch, P.; Vogt, Molly T.; Fu, Freddie H.; Moreland, Morey S.; Huard, Johnny

doi:10.1302/0301-620x.82b1.0820131

Cited by 166 publications

(156 citation statements)

References 21 publications

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“…Standard nonoperative therapy for acute muscle injuries usually involves rest, ice, compression, and elevation (RICE). Although experimental therapies such as platelet-rich plasma [15], suramin [6], and other such agents [14,30,42] are being tested, there is no clear consensus on nonoperative treatment of muscle injuries beyond the principle of short-term rest and ice.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and Imaging of an Untreated Grade III Hamstring Tear: A Case Report

Clark

Henn

Lovering

2011

Clinical Orthopaedics &Amp; Related Research

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Background Muscle strains are one of the most common complaints treated by physicians. High-force lengthening contractions can produce very high forces resulting in pain and tissue damage; such strains are the most common cause of muscle injuries. The hamstring muscles are particularly susceptible as they cross two joints and regularly perform lengthening contractions during running. We describe a patient with return to full function after a large hamstring tear. Case Description We report the case of a 26-year-old man who presented 1 year after a noncontact, left-sided proximal hamstring tear incurred while sprinting. He received no medical treatment or formal rehabilitation. He was able to return to all sports and activities 1 to 2 months after injury, but noted a persistent deformity of the proximal thigh, which led him to seek evaluation. Physical examination, MRI functional tests, and specific muscle tests 1 year after his injury documented a major hamstring tear at the musculotendinous junction with muscle retraction, but no avulsion of the proximal tendon attachment. Literature Review Surgery often is recommended for major proximal hamstring tendon tears, especially when more than one tendon of origin is ruptured from the ischial tuberosity. Myotendinous tears are treated nonoperatively, but may be associated with decreased strength, prolonged recovery, and recurrence. Purpose and Clinical Relevance We describe the case of a young man who sustained a hamstring tear, with retraction, at the proximal myotendinous junction, where the biceps femoris and semitendinosus arise from the conjoint tendon. He achieved full functional recovery without medical attention, but had a persistent cosmetic deformity and slight hamstring tightness. This case suggests a benign natural history for this injury and the appropriateness of noninvasive treatment.

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Section: Discussionmentioning

confidence: 99%

Evaluation and Imaging of an Untreated Grade III Hamstring Tear: A Case Report

Clark

Henn

Lovering

2011

Clinical Orthopaedics &Amp; Related Research

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“…Menetrey et al have shown b-FGF, IGF-1, and nerve growth factor (NGF) stimulate myoblast proliferation and fusion in vitro [12]. The researchers also demonstrated that serial injections of b-FGF and IGF-1 were associated with enhanced muscle regeneration, and increased fast-twitch and tetanic contraction strength in a controlled study of mice with lacerations of the gastrocnemius muscle.…”

Section: Pathophysiology and Mechanisms Of Muscle Healingmentioning

confidence: 99%

“…The healing phases of an injured muscle involve destruction characterized by hematoma and necrosis of myofibrils, phagocytosis of damaged tissues upon arrival of platelets, neutrophils, and macrophages [11,12]. This is followed a few days later by the start of the regenerative process.…”

Section: Pathophysiology and Mechanisms Of Muscle Healingmentioning

confidence: 99%

“…As they differentiate into myofibers and fuse together, remodeling and reorganization begins. As fibroblasts invade the gaps created by fused myofibers, they produce an extracellular matrix that restores tissue architecture, but may also lead to formation of dense scar tissue which can mitigate complete recovery [12]. The myogenic response is believed to play a critical role in the recovery of contractile function of skeletal muscle.…”

Section: Pathophysiology and Mechanisms Of Muscle Healingmentioning

confidence: 99%

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Platelet-rich plasma for muscle injuries: game over or time out?

Mosca

Rodeo

2015

Curr Rev Musculoskelet Med

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Muscle injuries are common and may be associated with impaired functional capacity, especially among athletes. The results of healing with conventional therapy including rest, ice, compression, and elevation (RICE) are often inadequate, generating substantial interest in the potential for emerging technologies such as platelet-rich plasma (PRP) to enhance the process of soft-tissue healing and to decrease time to recovery. In vitro studies and animal research have suggested that PRP may have benefits associated with the increased release of cytokines and growth factors resulting from supraphysiological concentrations of platelets that facilitate muscle repair, regeneration, and remodeling. Despite the promise of basic science, there is a paucity of clinical data to support the theoretical benefits of PRP. The only double-blind controlled clinical trial was recently reported and showed no benefit of PRP in the time to resume sports activity among athletes with hamstring muscle injury. This review examines the current evidence and the theoretical framework for PRP and muscle healing. Scientific gaps and technological barriers are discussed that must be addressed if the potential promise of PRP as a therapeutic modality for muscle injury is to be realized.

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“…bFGF, a strong mitogenic factor [41], enhances muscle regeneration [42] and myogenic cell migration [43]. Diaphragm bFGF expression is not well known.…”

Section: Transcription Factorsmentioning

confidence: 99%

Time-based gene expression programme following diaphragm injury in a rat model

Mehiri

Barreiro²,

Hayot³

et al. 2005

Eur Respir J

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It was hypothesised that diaphragm injury activates a time-based programme of gene expression in muscle repair.Gene expression of different substances, such as proteases (calpain 94 (p94)), transcription factors (myogenin and cFos), growth factors (both basic fibroblast growth factor (bFGF) and insulin-like growth factor (IGF)-II), and structural proteins (myosin heavy chain (MHC) and titin), was quantified by RT-PCR in rat diaphragms exposed to caffeine-induced injury. Injured and noninjured (control) rat hemidiaphragms were excised at different time points (1-240 h).In injured hemidiaphragms, in comparison with control muscles, p94 expression levels peaked at 1 h post-injury (PI), cFos mRNA levels began to rise, after an initial dip, and peaked at 96 h PI, while myogenin mRNA levels started to increase as early as 12 h PI, IGF-II mRNA levels initially decreased until 48 h PI and increased thereafter, peaking at 72 h PI, bFGF mRNA levels rose to a maximum at 96 h PI, and MHC and titin mRNA levels were significantly elevated at 72 h PI.Caffeine-induced diaphragm injury is followed by a time-based expression programme of different genes tailored to meet muscle repair needs.

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Growth factors improve muscle healing in vivo

Cited by 166 publications

References 21 publications

Evaluation and Imaging of an Untreated Grade III Hamstring Tear: A Case Report

Evaluation and Imaging of an Untreated Grade III Hamstring Tear: A Case Report

Platelet-rich plasma for muscle injuries: game over or time out?

Time-based gene expression programme following diaphragm injury in a rat model

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