1987
DOI: 10.1016/s0140-6736(87)90004-3
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Growth Failure and Growth-Hormone Deficiency After Treatment for Acute Lymphoblastic Leukaemia

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Cited by 191 publications
(105 citation statements)
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“…Clinical studies usually attribute effects on growth and craniofacial development to cranial irradiation (5, 9-11), although corticosteroids and chemotherapy are thought to be contributory (I, 32, 33). Clearly, it is not understood how radiation schedules and chemotherapy protocols interact to cause growth failure and growth hormone deficiency (3,34). The growth hormone requirements of children treated for ALL are still controversial (12).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Clinical studies usually attribute effects on growth and craniofacial development to cranial irradiation (5, 9-11), although corticosteroids and chemotherapy are thought to be contributory (I, 32, 33). Clearly, it is not understood how radiation schedules and chemotherapy protocols interact to cause growth failure and growth hormone deficiency (3,34). The growth hormone requirements of children treated for ALL are still controversial (12).…”
Section: Discussionmentioning
confidence: 99%
“…Lp., intraperitoneal(ly) P, treatment with prednisolone GRF, growth hormone-releasing factor M, treatment with methotrexate X. treatment with cranial irradiation CNS therapy for childhood ALL has welI-documented adverse effects on growth and cognition. The growth deficits include short stature, increased weight for height, microcephaly, midfacial hypoplasia, and mandibular retrognathia (1)(2)(3)(4)(5). The cognitive deficits do not include mental retardation or hyperactivity, but significant reductions in overall IQ scores develop, along with impaired verbal and visual-spatial memory abilities, attention, organization, and motor output (6)(7)(8) …”
mentioning
confidence: 99%
“…One cause of the growth retardation in patients with ALL is thought to be cranial irradiation, which affects growth hormone secretion, among other results. 32,33 Cranial irradiation, however, cannot be the only cause of growth retardation. Cytostatic treatment with drugs like 6-mercaptopurine, methotrexate and vincristine could decrease production of insulin-like growth factor (IGF-I), and high doses of steroids also affect growth rate.…”
Section: Height Heightmentioning
confidence: 99%
“…and the duration of the radiation therapy (16). In children treated with low range radiation doses the apparent frequency of GH deficiency may also depend on the type of stimulation testing: impairment of GH response to insulin-induced hypoglycemia but not to arginine stimulation was reported after 2400 cGy by some (1 7, 18) but not other investigators (19).…”
Section: Growth Hormone Deficiencymentioning
confidence: 99%