2023
DOI: 10.3390/metabo13020191
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Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice

Abstract: Growth hormone (GH) has established effects on protein metabolism, such as increasing protein synthesis and decreasing amino acid degradation, but its effects on circulating amino acid levels are less studied. To investigate this relationship, metabolomic analyses were used to measure amino acid concentrations in plasma and feces of mice with alterations to the GH axis, namely bovine GH transgenic (bGH; increased GH action) and GH receptor knockout (GHRKO; GH resistant) mice. To determine the effects of acute … Show more

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Cited by 4 publications
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“…Although not studied in this report, higher serum glycine levels reduced the risk of pancreatic cancer by 70%, as observed in a prospective cohort study in human patients [69]. In this regard, bGH transgenic mice, which develop spontaneous neoplasms at a higher rate than WT mice [70], also have markedly lower glycine levels than their WT counterparts, while the reverse is observed in GHR-knockout (GHRKO) mice, which are protected from cancer [71].…”
Section: Discussionmentioning
confidence: 48%
“…Although not studied in this report, higher serum glycine levels reduced the risk of pancreatic cancer by 70%, as observed in a prospective cohort study in human patients [69]. In this regard, bGH transgenic mice, which develop spontaneous neoplasms at a higher rate than WT mice [70], also have markedly lower glycine levels than their WT counterparts, while the reverse is observed in GHR-knockout (GHRKO) mice, which are protected from cancer [71].…”
Section: Discussionmentioning
confidence: 48%