Growth Hormone and Corticotropin

Astwood, E. B.

doi:10.1016/b978-0-12-395714-6.50013-7

Cited by 101 publications

(14 citation statements)

References 310 publications

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“…Similar observations have been made by Astwood (6). The metabolic responses to adrenocorticotropic hormone (ACTH) in both intact and adrenalectomized animals bear a striking similarity to those induced by growth hormone (Table I) and some have also been elicited with the thyroid stimulating hormone (2,3).…”

supporting

confidence: 70%

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Lipolytic Action of Corticotropin on Rat Adipose Tissue In Vitro12

White¹,

Engel²

1958

J. Clin. Invest.

234

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supporting

confidence: 70%

“…The same hormone has been found capable of inducing ketosis, fatty liver and a loss of extractable lipid from adipose tissue depots in mice and rats (2,4,6,8 …”

mentioning

confidence: 94%

Lipolytic Action of Corticotropin on Rat Adipose Tissue In Vitro12

White¹,

Engel²

1958

J. Clin. Invest.

234

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“…In acromegaly the enlargement of other viscera, such as the heart and kidneys, results from an increase in cell size (Daughaday, 1968), and tissues like the renal glomerulus increase in size rather than number (Cushing and Davidoff, 1927). Bartlett in 1971 studied the effect of HGH on the rat lung but this experiment produced a disease more similar to human gigantism than acromegaly because the epiphyses of rat long bones never close (Astwood, 1955). The effect, therefore, of HGH on human lung is not fully understood and requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function in acromegaly.

Evans¹,

Hipkin²,

Murray³

1977

Thorax

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. Pulmonary function in acromegaly. The lung volumes of 12 female and eight male patients with acromegaly, chosen because of the absence of associated cardiorespiratory disease, were determined physiologically and radiographically. Enlarged lung volumes were found in half the males but in none of the females, due allowance being made for the presence of a significant thoracic kyphosis. Upper airway narrowing was suggested by an increase in the expiratoryinspiratory flow rate ratio in six patients, four of whom were male, and acromegaly of the larynx was confirmed in the three subjects who consented to laryngoscopy. Upper airway obstruction is more likely to account for respiratory death in acromegaly than disordered pulmonary function in enlarged acromegalic lungs. Neither of these respiratory findings could be correlated with the fasting level of growth hormone but there was a suggestion that they were more likely to occur when the duration of the disorder was longer.Enlargement of visceral organs such as the heart and kidney is a well recognised manifestation of acromegaly (Cushing and Davidoff, 1927;Gordon et al., 1962). The lung volumes in this condition have been measured in few subjects and the results are disparate. Brody et al. (1970) showed that in six male acromegalics the total lung capacity (TLC), functional residual capacity (FRC), and vital capacity (VC) were increased up to a mean of 140% predicted, whereas in four females these volumes were normal. In contrast, Toppell et al. (1973) found that the TLC and VC were increased in seven females with acromegaly up to a mean of 111% and 116% predicted respectively. They confirmed increases in the TLC, VC, and residual volume (RV)

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“…The normal birth weight and growth during infancy of idiopathic hypopituitary dwarfs seem to support further the limited influence of growth hormone as a growth-promoting agent during gestation and infancy (14,54). It (39).…”

Section: Resultsmentioning

confidence: 87%

“…In man, the macrosomia observed in infants born to prediabetic or diabetic mothers has been attributed by some to an excess of maternal circulating growth hormone (4,(6)(7)(8)(9), thus implying transplacental passage of this growth-promoting substance and response of the fetal organism to exogenous hormone. Conversely, the normal birth weight of infants born to women with active acromegaly (10)(11)(12) and the relatively unimpaired growth of apituitary fetuses do not seem to support this hypothesis (13)(14)(15)(16)(17)(18).…”

mentioning

confidence: 99%