Growth Hormone and Glucose Interrelationships in Diabetes: Studies with Insulin Infusion During Continuous Blood Glucose Analysis

Fatourechi, Vahab; Molnar, George D.; Ackerman, Eugene; Rosevear, John W.; Moxness, Karen E.; Taylor, William F.

doi:10.1210/jcem-29-3-319

Cited by 37 publications

(14 citation statements)

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“…These data are consistent with those of Fatourechi et al [6], who reported normal GH responses to insulin-induced hypoglycaemia in patients with Type2 diabetes mellitus. GH levels following GHRH administration were significantly blunted in obese compared with non-obese Type 2 diabetic patients.…”

Section: Discussionsupporting

confidence: 93%

Effect of growth hormone releasing hormone on growth hormone secretion in Type 2 (non-insulin-dependent) diabetes mellitus

Pietschmann

Schernthaner

1987

Diabetologia

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Growth hormone levels following an intravenous bolus injection of 1 micrograms/kg body weight growth hormone releasing hormone were measured in 21 non-obese and 26 obese patients with Type 2 (non-insulin-dependent) diabetes mellitus and in 13 control subjects. Growth hormone responses in non-obese Type 2 diabetic patients were not statistically different from control subjects. However, obese Type 2 diabetic patients had significantly decreased growth hormone responses to growth hormone releasing hormone when compared with non-obese Type 2 diabetic patients (p less than 0.02). In 9 Type 2 diabetic patients growth hormone releasing hormone tests were performed both during hyperglycaemia and after metabolic improvement by insulin treatment. Growth hormone responses before and after insulin treatment were not statistically different. Our data demonstrate that growth hormone responses to growth hormone releasing hormone in non-obese Type 2 diabetic patients do not differ significantly from control subjects; obesity blunts growth hormone responses to growth hormone releasing hormone in Type 2 diabetes mellitus; and growth hormone responses following growth hormone releasing hormone administration in Type 2 diabetes mellitus are not influenced by the state of metabolic control.

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Section: Discussionsupporting

confidence: 93%

Effect of growth hormone releasing hormone on growth hormone secretion in Type 2 (non-insulin-dependent) diabetes mellitus

Pietschmann

Schernthaner

1987

Diabetologia

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“…An increased GH response to exercise has been reported in poorly controlled insulindependent subjects, although the response was normalized in this same group of patients when control was optimized (4,5). GH release appears abnormal in insulindependent diabetics in that hyperglycemia does not inhibit the response of GH to provocative maneuvers, such as arginine infusion or L-dopa, and an altered glucoreceptor has been postulated to explain this response (6)(7)(8)(9).…”

mentioning

confidence: 72%

“…Previous studies have suggested that GH levels are inappropriate (1,2,6,9,21) and that the control of GH secretion is impaired (6)(7)(8)(9) in diabetic patients. The present study was undertaken to explore another parameter that might reflect abnormalities in GH release, namely response to TRH.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Response to Thyrotropin-Releasing Hormone in Diabetes*

Dasmahapatra

Urdanivia

Cohen

1981

The Journal of Clinical Endocrinology & Metabolism

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The effect of TRH on GH secretion was assessed in 13 insulin-dependent diabetics. PRL and TSH responses to TRH were also determined. Glycosylated hemoglobin levels and serial fasting glucose concentrations indicated that all but 1 of the patients had a period of poor diabetic control for several months before the study. Peak PRL and TSH levels after TRH injection in these diabetic patients did not differ significantly from values observed in nondiabetic individuals. Six of the patients responded to TRH with a significant rise in GH levels; basal GH concentrations were also elevated in these patients. Five of the 6 responders and none of the nonresponders had proliferative diabetic retinopathy. The results suggest that diabetics with elevated basal GH levels hyperrespond to TRH, and that nonspecific secretion of GH in response to TRH occurs in some patients with proliferative diabetic retinopathy. Chronic hyperglycemia does not appear to be the critical factor in determining this response.

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“…Recently a few reports have indicated abnormalities of serum growth hormone in diabetes mellitus during fasting, throughout a 24 hr period of daily life, and in response to various stimuli (1)(2)(3)(4)(5)(6)(7)(8)(9). Strong exercise is a potent stimulus for growth hormone secretion in normal subjects (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%