Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions

Hull, Kerry; Harvey, S.

doi:10.1155/2014/234014

Cited by 134 publications

(135 citation statements)

References 342 publications

(473 reference statements)

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“…Physiologic function of granulosa cell is dependent on paracrine and autocrine cytokines in ovarian microenvironment and reproductive hormones in peripheral blood [12]. The reduced number of granulosa cells and disruption in the cell-cell communication might have deprived oocyte of nutrients and survival factors inside the preovulatory follicle and induced apoptosis in ovulated oocytes.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

et al. 2017

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Reactive oxygen species (ROS) play important roles in follicular development and survival. Granulosa cell death is associated with increased ROS, but the mechanism of granulosa cell death induced by ROS is not clear. In order to define the molecular link between ROS and granulosa cell death, COV434, human granulosa tumor cells, were treated with H2O2. Compared to control cells, H2O2 induced granulosa cell death in a dose- and time-dependent manner. H2O2 induced an increase in Bax, Bak and Puma, and a decrease in anti-apoptotic molecules such as Bcl-2, Bcl-xL and Mcl-1. Both knockdown of Puma and overexpression of Bcl-xL could inhibit H2O2-induced granulosa cell death. These results suggest that suppression of Puma and overexpression of anti-apoptotic Bcl-2 family members could improve granulosa cell survival. To explore the mechanisms responsible for these findings, ROS in granulosa cells treatment with H2O2 were measured. The results showed that ROS was increased in a H2O2 dose- and time-dependent manner at the earlier time point. In addition, H2O2 induced an increase in Nrf2 and phosphorylation of JNK and p53. SP600125, an inhibitor of JNK, inhibits H2O2-induced phosphorylation of JNK and p53, and granulosa cell death. Antioxidant N-acetylcysteine (NAC) dose-dependently prevents H2O2-induced granulosa cell death. Furthermore, NAC also prevents phosphorylation of JNK and p53 induced by H2O2. Taken together, these data suggest that H2O2 regulates cell death in granulosa cells via the ROS-JNK-p53 pathway. These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be useful for future clinical applications.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

et al. 2017

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“…The chicken growth hormone is widely known as a major hormone that acts directly on chicken development and metabolism (Kim, 2010) and relates to egg production (Su et al, 2014;Vu & Ngu, 2016). GH regulates a variety of physiological functions such as growth, body composition, egg production, aging, reproduction, sexual maturation, and functionality of the central nervous system (Gosney et al, 2012;Hrabia et al, 2008;Hull & Harvey, 2014;Stephen et al, 2001). The GH/ IGF-1 signaling pathway is also believed to be capable of promoting growth of selected types of cancer (Kopchick et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Khaerunnisa

Jakaria

Arief

et al. 2017

Med Pet

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The chicken growth hormone (GH) and its receptor (growth hormone receptor, GHR) play important roles in chicken performances due to their crucial functions in growth. The variations of GH and GHR genes were then thought to be associated with the variations of the performances. This experiment was designed to identify the g.2248G>A GH and the g.565G>A GHR loci polymorphisms and to evaluate their associations with carcass components in Kampung and broiler chicken cross. A total of 215 chickens including 4 chicken populations (Kampung, Cobb broiler, F1, and F2 Kampung x broiler chicken cross) were screened to identify polymorphism using PCR-RFLP technique with EcoRV and Eco72I restriction enzyme for GH and GHR loci, respectively. The carcass components were recorded at 26 weeks of age on F2 Kampung and broiler chicken cross (42 chickens) for association study. Both the g.2248G>A GH and the g.565G>A GHR loci were polymorphic with two alleles (G and A) and three genotypes (GG, AG, and AA). The GG genotype and the G allele of GH locus were predominant in all chicken populations. While in GHR locus, the AA genotype and the A allele were found to be higher in all chicken populations. The association study showed that the g.565G>A GHR locus polymorphism had significant effect on carcass components, including live weight, carcass weight, breast weight, thighs weight, breast muscle weight, and thighs muscle weight. There was no significant association was found between the g.2248G>A GH genotype and carcass components. It could be concluded that the g.2248G>A GH and the g.565G>A GHR loci were polymorphic in Kampung and broiler chicken cross and the g.565G>A GHR locus was accosiated with carcass components. This g.565G>A GHR SNP might be an important candidate marker for chicken growth and muscle mass improvement. Keywords: Kampung chicken cross, growth hormone, growth hormone receptor, gene polymorphisms, carcass ABSTRAKHormon pertumbuhan dan reseptor hormon pertumbuhan memiliki peran penting dalam performa pertumbuhan ayam. Tujuan penelitian ini adalah mengidentifikasi keragaman gen hormon pertumbuhan (lokus g.2248G>A GH) dan gen reseptor hormon pertumbuhan (lokus g.565G>A GHR) dan mengevaluasi pengaruhnya pada komponen karkas pada ayam silangan Kampung dan broiler. Penentuan genotipe dilakukan pada 215 ekor ayam, yang terdiri atas 4 populasi (Kampung, ras pedaging strain Cobb, silangan F1 dan F2 Kampung x ras pedaging strain Cobb) menggunakan enzim pemotong EcoRV dan Eco72I masing-masing untuk fragmen lokus g.2248G>A GH dan lokus g.565G>A GHR. Analisis asosiasi dengan komponen karkas dilakukan pada populasi ayam silangan F2 Kampung x ras pedaging strain Cobb umur 26 minggu. Kedua lokus tersebut bersifat polimorfik dengan dua alel yang ditemukan (alel A dan G) dan tiga genotipe (genotipe GG, AG, dan AA). Genotipe GG dan alel G pada lokus g.2248G>A GH ditemukan dalam frekuensi tertinggi di semua populasi yang diuji. Sementara pada lokus g.565G>A GHR, genotipe AA dan alel A ditemukan paling dominan. Analisis asosiasi...

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“…Both growth hormone and IFG-1 play a role in the recruitment of ovarian follicles [7]. When GH is deficient there is a decrease in ovarian sensitivity to FSH leading to monofollicular growth as opposed to a recruitment of a dominant follicle and perhaps decreased stimulation of all antral follicles [8,9].…”

Section: Introductionmentioning

confidence: 99%

Normalization of anti-mullerian hormone level after growth hormone replacement in a patient with congenital growth hormone deficiency: A case study

Purdy¹,

Leonard²,

Rhodes³

et al. 2018

Clin Obstet Gynecol Reprod Med

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Objective: To describe a case of congenital growth hormone deficiency in a patient that had return of ovarian function after growth hormone replacement following undetectable levels of anti-mullerian hormone (AMH) level. Design: Case Study.Setting: Mayo Clinic. Patient(s):A 32-year-old woman with congenital growth hormone deficiency (CGHD) was evaluated at Mayo Clinic and noted to have an undetectable AMH level. Intervention(s):The patient was started on Humatrope at a dose of 0.4mg daily. Patient was escalated on growth hormone therapy until her IGF-1 levels were within normal range. Main Outcome Measure(s):Return of cyclical menses and increase in AMH level to normal range. Results:After 12 months of GH replacement, the patient's menses had returned to regular 28-day cycles and her hypoestrogenic symptoms had resolved. Her GH was adequately replaced with an IGF-1 level of 151ng/mL. Her AFC had increased to 16 from a previous ultrasound depicting 1 antral follicle and her laboratory tests had returned to normal levels; FSH 7.7IU/L, estradiol 33 pg/mL and AMH 1.9 ng/mL. Conclusion:This documents a patient with CGHD and suppressed AMH levels. In this case, GH correction played a significant role in restoring ovarian function. Assessing ovarian reserve status in adolescent patients with CGHD is a key component in their evaluation and may allow for oocyte cryopreservation in young girls that have normalization of ovarian function after treatment. This is important, as there is unclear data on the long term fertility potential of patients with CGHD. AMH has been shown to be a marker of ovarian reserve in a patient with CGHD which demonstrated a dynamic shift in AMH that was related to the patient's GH status.

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Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions

Cited by 134 publications

References 342 publications

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Normalization of anti-mullerian hormone level after growth hormone replacement in a patient with congenital growth hormone deficiency: A case study

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