Growth Hormone Deficiency in Patients with Sickle Cell Disease and Growth Failure

Nunlee-Bland, Gail; Rana, Sohail; Houston-Yu, Patricia; Odonkor, Wolali

doi:10.1515/jpem.2004.17.4.601

Cited by 22 publications

(26 citation statements)

References 7 publications

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“…[26][27][28][29][30][31] Growth hormone deficiency may account for a small percentage of children with SCD who have severe growth delay. 32 Hemolysis, chronic anemia, and a high metabolic rate appear to be the most significant adverse factors for growth in SCD. Resting energy expenditure was increased in several studies of children with SCD and is probably related to anemia, chronic inflammation, high cardiac output, and high protein turnover.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyurea and Growth in Young Children With Sickle Cell Disease

et al. 2014

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BACKGROUND: Growth impairment is a known complication of sickle cell disease. Effects of hydroxyurea (HU) on growth in very young children are not known. METHODS: Height, weight, BMI, and head circumference (HC) were compared with World Health Organization (WHO) standards in BABY HUG, a multicenter, randomized, double-blinded, placebo-controlled 2-year clinical trial of HU in 193 children 9 to 18 months of age. Anthropometric data were closely monitored and converted to z scores by using WHO standardized algorithms for descriptive analyses. The treatment and placebo groups were compared longitudinally by using a mixed model analysis. RESULTS: At entry, the z scores of BABY HUG children were higher than WHO norms. After 2 years of HU or placebo treatment, there were no significant differences between the groups, except for the mean HC z scores at study exit (HU: +0.8 versus placebo: +1.0, P = .05). Baseline z scores were the best predictors of z scores at study exit. The absolute neutrophil count, absolute reticulocyte count, and total white blood cell count had significant negative correlations with growth measures. CONCLUSIONS: Both groups had normal or near normal anthropometric measures during the study. The HC z scores at study entry and exit were slightly greater than WHO norms. Higher baseline white blood cell count, absolute reticulocyte count, and absolute neutrophil count were associated with poorer growth. The significance of the slightly lower HC in the treatment group at study exit is not clear. Trends toward normalization of weight and height and effects on HC will be monitored in ongoing BABY HUG follow-up studies.

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Section: Discussionmentioning

confidence: 99%

Hydroxyurea and Growth in Young Children With Sickle Cell Disease

et al. 2014

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“…Abnormalities in gonadotropin secretion patterns (elevated luteinizing hormone and depressed follicle-stimulating hormone in early puberty) in boys and girls with SCD (19) and poor testosterone response to gonadotrophin-releasing hormone in some boys (20) suggest impairments in the regulatory feedback mechanisms of the hypothalamic-pituitary-gonadal axis leading to sexual maturity. Growth hormone abnormalities have also been reported (21)(22)(23).…”

Section: Growth Failure In Sickle Cell Diseasementioning

confidence: 93%

Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity on Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease

et al. 2007

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“…An international inquiry showed that these tests were recommended in most countries with guidelines for diagnostic work up [36]. The available literature shows that there is a strong relationship between thalassemia, sickle cell disease and growth retardation [127][128][129][130]. Likewise, Stephensen et al showed evidence of the association between infectious diseases and linear growth [131].…”

Section: The Diagnostic Processmentioning

confidence: 99%