Growth Hormone Facilitates Ovulation Induction by Gonadotrophins

Homburg, Roy; Eshel, A.; Abdalla, Hossam; Jacobs, Howard S.

doi:10.1111/j.1365-2265.1988.tb00252.x

Cited by 250 publications

(95 citation statements)

References 7 publications

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“…Recently, we have demonstrated that the administration of exogenous growth hormone (GH) supplementation, in conjunction with standard ovarian stimulation regimens, resulted in significantly higher embryo implantation and clinical pregnancy rates compared with those not treated with GH (Yovich & Stanger 2010). These findings are supported by previous studies demonstrating the beneficial effect of GH in increasing the response of human ovary to gonadotrophins in poor-responder patients (Homburg et al 1988, Volpe et al 1989, Hazout et al 2009). The improvement in clinical outcomes was likely achieved via an improvement in oocyte developmental competence, rather than the result of an increased yield of oocytes or effects on the endometrium as the benefits continued to express in subsequent frozen embryo transfer cycles.…”

Section: Introductionsupporting

confidence: 77%

A direct action for GH in improvement of oocyte quality in poor-responder patients

Weall¹,

Al-Samerria²,

Conceicao³

et al. 2015

Reproduction

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Declining female fecundity at later age and the increasing tendency for women to delay childbirth have lead to a drastic rise in the number of women seeking assisted reproductive technology. Many women fail to respond adequately to standard ovarian stimulation regimens, raising a significant therapeutic challenge. Recently, we have demonstrated that the administration of GH, as an adjunct to ovarian stimulation, has improved the clinical outcomes by enhancing the oocyte quality. However, the mechanism(s) by which GH facilitated this improvement is yet to be understood. This study aimed to determine these potential mechanism(s) through the use of immunofluorescent localisation of GH receptors (GHRs) on the human oocyte and unbiased computer-based quantification to assess and compare oocyte quality between women of varying ages, with or without GH treatment. This study demonstrates for the first time, the presence of GHRs on the human oocyte. The oocytes retrieved from older women showed significant decrease in the expression of GHRs and amount of functional mitochondria when compared with those from younger patients. More interestingly, when older patients were treated with GH, a significant increase in functional mitochondria was observed in their oocytes. We conclude that GH exerts a direct mode of action, enabling the improvement of oocyte quality observed in our previous study, via the upregulation of its own receptors and enhancement of mitochondrial activity. This result, together with recent observations, provides scientific evidence in support of the use of GH supplementation for the clinical management of poor ovarian response.

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Section: Introductionsupporting

confidence: 77%

A direct action for GH in improvement of oocyte quality in poor-responder patients

Weall¹,

Al-Samerria²,

Conceicao³

et al. 2015

Reproduction

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“…One other option is administration of growth hormone (GH) to potentiate the effect of exogenous gonadotropins [3]. Growth hormone is reported to modulate the action of FSH on granulosa cells by up-regulating the local synthesis of insulin-like growth factor-I.…”

Section: Introductionmentioning

confidence: 99%

Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial

Küçük

Kozinoglu²,

Kaba³

2008

J Assist Reprod Genet

106

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“…In fact, several studies have demonstrated that GH treatment increases ovary sensitivity to gonadotropin stimulation in infertile women with hyposensitive ovaries (12)(13)(14)(15)(16)(17)(18)(19). The effect of GH administration on gonadal function in men has been poorly investigated.…”

Section: Introductionmentioning

confidence: 99%

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

Carani

Granata²,

Rosa³

et al. 1999

European Journal of Endocrinology

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Eleven adult males, previously submitted to neurosurgery because of a pituitary lesion (three with craniopharyngioma, three with clinically non-functioning adenoma and five with macroprolactinoma) were treated with recombinant GH for 12 months after the diagnosis of GH deficiency was made. Circulating FSH, LH, prolactin, testosterone, 17b-estradiol (E 2 ), dehyroepiandrosterone (DHEA-S), androstenedione, 17-OH-progesterone (17OHP), IGF-I, and steroid hormone-binding protein (SHBG) levels were assayed before and after CG test at study entry and 6 and 12 months after GH treatment.A significant increase in plasma IGF-I levels was obtained after 6 and 12 months of GH treatment. In addition, CG-stimulated, but not baseline, testosterone levels showed a significant increase after 6 and 12 months of GH treatment when compared with study entry (9.6Ϯ0.5 and 9.9Ϯ0.5 vs 7.9Ϯ0.5 ng/ ml; P<0.05). Baseline, but not CG-stimulated, serum 17OHP levels were significantly increased only after 12 months of GH treatment (1.7Ϯ0.1 vs 1.4Ϯ0.1 ng/ml; P<0.05). No significant difference was found as far as both basal and CG-stimulated E 2 , androstenedione, DHEA-S and SHBG were concerned. With regards to the semen analysis, only seminal plasma volume was significantly increased after 12 months of GH treatment (2.9Ϯ0.3 vs 1.7Ϯ0.3 ml; P<0.05). No significant change in sperm count, motility and abnormal forms was observed.These data show that GH treatment displays a clear-cut effect upon Leydig cell function and increases the production of seminal plasma volume in fertile adult males with isolated GH deficiency.

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Growth Hormone Facilitates Ovulation Induction by Gonadotrophins

Cited by 250 publications

References 7 publications

A direct action for GH in improvement of oocyte quality in poor-responder patients

A direct action for GH in improvement of oocyte quality in poor-responder patients

Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial

The effect of chronic treatment with GH on gonadal function in men with isolated GH deficiency

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