Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction

Akın, Fulya; Yaylalı, Güzin Fidan; Turgut, Sebahat; Kaptanoǧlu, Bünyamin

doi:10.1016/j.ghir.2008.11.003

Cited by 26 publications

(34 citation statements)

References 29 publications

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“…IGF-1 and IGFBP-3 levels of our study group were similar to those of control group. This finding was inconsistent with Akin's data [25]. Our findings suggest that in adult population with normal thyroid hormone levels and high TSH, IGF-1 and IGFBP-3 axis seem to be unaffected, and this finding is similar to that of Bona et al, who worked with treated patients with normalized TSH levels; but larger studies are needed to elucidate the interaction between thyroid and IGF and IGFBP systems [18].…”

Section: Discussioncontrasting

confidence: 99%

“…Recently, Akin et alreported that patients with untreated subclinical hypothyroidism had similar IGF-1 and significantly lower IGFBP-3 and levels compared to control subjects. They also found a significant correlation between IGF-1 and IGFBP-3 levels [25]. In our study, we also found a significant correlation between IGF-1 and IGFBP-3 in control group, but not in patients with subclinical hypothyroidism.…”

Section: Discussionsupporting

confidence: 79%

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Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

et al. 2011

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AbstractThyroid status is known to influence growth in mammals. The aim of this study is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients’ group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 79%

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

et al. 2011

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“…Several studies have reported a reduction in IGF1 levels in adults with overt and SH (17). Recently, Akim et al (18) reported low serum IGF1 levels in adults with SH, compared to euthyroid subjects, which significantly increased after normalization of thyroid function with L-T 4 therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Normal IQ score was considered to be between 80 and 115, with scale scores for each subtest having a mean of 10 and S.D. of 3 (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]). An IQ score between 80 and 90 was considered to be low-normal.…”

Section: Intellectual Evaluationmentioning

confidence: 99%

Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism

Cerbone

Bravaccio²,

Capalbo³

et al. 2011

European Journal of Endocrinology

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Objective: The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine. Design and methods: Clinical and auxological parameters, thyroid function, and intellectual outcome were evaluated in 36 children with persistent SH at the age of 9.7G0.6 (range 4-18.0) years. Children had been followed longitudinally for 3.3G0.3 (range 2.0-9.3) years, from first diagnosis of SH until enrollment in the study. Thirty-six age-and sex-matched children were enrolled in the study as controls. Results: At study entry, height (K0.8G0.2 SDS), bone age/chronological age (BA/CA ratio 0.92 G0.6), and body mass index (BMI K0.1G0.2 SDS) in SH children were normal. Despite long-term duration of SH, none of these parameters showed a worsening with respect to height (K0.7G0.2 SDS), BA/CA (0.97G0.03), and BMI (K0.1G0.2) at the time of first SH detection. None of the children showed overt signs or symptoms of hypothyroidism during the follow-up. Verbal (99.1G2.2), performance (100.4G1.9), and full-scale (99.7G1.9) intelligence quotient (IQ) scores in SH children were normal and comparable to those of controls. No relationship was detected between IQ scores and the degree or duration of SH. Conclusions: Persistent SH in children is not associated with alterations in growth, bone maturation, BMI, and cognitive function or other complaints that could be ascribed to SH even after several years without therapeutic intervention.

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“…Normal thyroid hormone levels are necessary for the optimal effect of growth hormone (GH) on the growth rate and a complex interdependent relationship between GH-insulin growth factor-1 (IGF-1) and the hypothalamic-pituitary-thyroid (HPT) axis is well documented [1,2,3,4]. Alterations in the HPT axis have been reported following GH treatment both in adults and children affected by GH deficiency (GHD), but the mechanism of HPT changes during GH replacement are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Severity of Growth Hormone Deficiency and Thyroid Metabolism and Effects of Long-Term Growth Hormone Treatment on Thyroid Function in Children with Idiopathic Growth Hormone Deficiency

Ciresi

Guarnotta²,

Amato³

et al. 2014

Horm Res Paediatr

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Background/Aim: The significance of changes in thyroid function in children during growth hormone (GH) treatment remains uncertain. We aimed to evaluate the impact of GH replacement on thyroid status in children with idiopathic GH deficiency (GHD). Methods: Data of 105 GHD children (82 M, 23 F; aged 11.13 years) during a 36-month follow-up were analyzed. At diagnosis the areas under the curve of GH (AUC_GH) were calculated during a GH-releasing hormone + arginine (GHRH-Arg) and insulin tolerance test. Results: A significant ΔfT₃ (p < 0.001) was documented at 12 months, without any further change at 24 and 36 months and without fT₄ and TSH modifications. Grouping patients according to ΔfT₃ at 12 months into those with lower (n = 80, 76%) or greater values than the 75th percentile (n = 25, 24%), the latter showed lower AUC_GH and GH peak during a GHRH-Arg (p = 0.018 and 0.014, respectively) and insulin tolerance test (p = 0.023 and 0.020, respectively) at diagnosis. In addition, children with lower GH at diagnosis showed a greater ΔfT₃ at 12 months (p = 0.030). Conclusions: In GHD children, GH treatment is associated with a significant increase in fT₃ in the first 12 months, more pronounced in patients with more severe GHD, highlighting the strong correlation between severity of GHD and thyroid metabolism.

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Growth hormone/insulin-like growth factor axis in patients with subclinical thyroid dysfunction

Cited by 26 publications

References 29 publications

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism

Correlation between Severity of Growth Hormone Deficiency and Thyroid Metabolism and Effects of Long-Term Growth Hormone Treatment on Thyroid Function in Children with Idiopathic Growth Hormone Deficiency

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