Growth Hormone, Insulin-Like Growth Factors, and the Ovary

Bondy, Carolyn A.; Zhou, Jian; Arraztoa, J

doi:10.1016/b978-012515400-0/50018-x

Cited by 5 publications

(3 citation statements)

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“…Nevertheless, little information was found on the specific molecular pathways implicated in GH effects in the ovary [ 25 ] and no data has been reported on the radioprotective role of GH in ovarian damage induced by γ-irradiation in vivo . Therefore, the present study was designed to explore the modulatory effects of GH on radiation-induced ovarian dysfunction in vivo as well as the possible underlying mechanisms; particularly, its impact on the ovarian reserve, oxidative stress, proliferation, apoptosis and the impact on IGF-1/IGF-1R axis.…”

Section: Introductionmentioning

confidence: 99%

Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis

et al. 2015

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Radiotherapy is one of the standard cytotoxic therapies for cancer. However, it has a profound impact on ovarian function leading to premature ovarian failure and infertility. Since none of the currently available methods for fertility preservation guarantees future fertility, the need for an effective radioprotective agent is highly intensified. The present study investigated the mechanisms of the potential radioprotective effect of growth hormone (GH) on γ irradiation-induced ovarian failure and the impact of the insulin like growth factor 1 (IGF-1) in the underlying protection. Immature female Sprague-Dawley rats were either exposed to single whole body irradiation (3.2 Gy) and/or treated with GH (1 mg/kg s.c). Experimental γ-irradiation produced an array of ovarian dysfunction that was evident by assessment of hormonal changes, follicular development, proliferation marker (PCNA), oxidative stress as well as apoptotic markers. In addition, IGF-1/IGF-1R axis expression was assessed using real-time PCR and immunolocalization techniques. Furthermore, after full maturity, fertility assessment was performed. GH significantly enhanced follicular development and restored anti-Mullerian hormone serum level as compared with the irradiated group. In addition, GH significantly ameliorated the deleterious effects of irradiation on oxidative status, PCNA and apoptosis. Interestingly, GH was shown to enhance the ovarian IGF-1 at transcription and translation levels, a property that contributes significantly to its radioprotective effect. Finally, GH regained the fertility that was lost following irradiation. In conclusion, GH showed a radioprotective effect and rescued the ovarian reserve through increasing local IGF-1 level and counteracting the oxidative stress-mediated apoptosis.

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Section: Introductionmentioning

confidence: 99%

Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis

et al. 2015

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“…Insulin-like growth factors (IGFs: IGF-1 and IGF-2), primary mediators of somatic growth, play essential roles in gonadal development and maturation in a wide variety of vertibrates. In mammals, IGFs have been shown to affect gonadal steroidogenesis, differentiation and proliferation of somatic cells in the gonads, and be involved in oocyte maturation (Bondy et al, 2006). IGF-1 has also been shown to potentiate the stimulatory effects of gonadotropins on steroid production and expression of steroidogenic enzymes in mammalian theca cells (Bondy et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…In mammals, IGFs have been shown to affect gonadal steroidogenesis, differentiation and proliferation of somatic cells in the gonads, and be involved in oocyte maturation (Bondy et al, 2006). IGF-1 has also been shown to potentiate the stimulatory effects of gonadotropins on steroid production and expression of steroidogenic enzymes in mammalian theca cells (Bondy et al, 2006). In teleosts, as in mammals, IGF-1 stimulates steroid production in the ovarian follicles.…”

Section: Introductionmentioning

confidence: 99%

Insulin-like growth factors 1 and 2 regulate gene expression and enzymatic activity of cyp17a1 in ovarian follicles of the yellowtail, Seriola quinqueradiata

Higuchi

Kazeto

Ozaki

et al. 2020

Heliyon

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There is accumulating evidence that insulin-like growth factors (IGFs), primary mediators of somatic growth, play an important role in fish reproduction. Previously, we showed that IGF-1 and IGF-2 are expressed in the ovarian follicle cells of the yellowtail (Seriola quinqueradiata) during the vitellogenic phase, suggesting that IGFs may be involved in ovarian steroidogenesis. In this study, we examined the effects of IGF-1 and IGF-2 on gene expression and activity of steroidogenic enzymes in yellowtail ovary in vitro. IGF-1 and IGF-2 had no effect on mRNA levels of several steroidogenesis-related genes (star, cyp11a1, hsd3b, cyp17a2, and cyp19a1). However, both IGFs enhanced the transcription of cyp17a1 in vitellogenic ovaries, although such up-regulation was not found in the ovary at the pre-vitellogenic stage. The stage-dependent effects of IGFs were correlated with changes in ovarian cyp17a1 mRNA levels during the reproductive cycle: transcript abundances increased in conjunction with ovarian development. In addition, IGF-induced cyp17a1 gene expression was significantly inhibited by wortmannin, suggesting that PI3 kinase plays an essential role in IGF-mediated ovarian steroidogenesis. Furthermore, IGF-1 and IGF-2 promoted the conversion of both progesterone and 17α-hydroxyprogesterone to androstenedione in vitellogenic ovaries, suggesting that both IGFs stimulated 17α-hydroxylase and C 17-20 lyase activities. Taken together, these findings suggest that IGF-1 and IGF-2 act directly on follicle cells to stimulate steroid production through an increase in gene expression and enzymatic activity of cyp17a1 via induction of PI3 kinase.

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Structure, Function, and Regulation of the Corpus Luteum

Stouffer

2006

Knobil and Neill's Physiology of Reproduction

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Growth Hormone, Insulin-Like Growth Factors, and the Ovary

Cited by 5 publications

References 194 publications

Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis

Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis

Insulin-like growth factors 1 and 2 regulate gene expression and enzymatic activity of cyp17a1 in ovarian follicles of the yellowtail, Seriola quinqueradiata

Structure, Function, and Regulation of the Corpus Luteum

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