Growth hormone levels in relation to birth weight and gestational age

Rajesh, Gopinath; Bhat, B. Vishnu; Sridhar, Magadi Gopalakrishna; Ranganathan, Pradeep Krishna

doi:10.1007/bf02723656

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Although several steroids including progesterone, 17-hydroxyprogesterone (17-OHP), cortisol, and growth hormones have been found to be inversely associated with infant birth weight, newborn hormone levels are influenced by many factors such as delivery type, gestational age, maternal height, maternal hormone levels, and the day of sample collection (Carlsen et al 2006; Lagiou et al 2014; Rajesh et al 2000; Schwarz et al 2009). …”

Section: Resultsmentioning

confidence: 99%

An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies

et al. 2017

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Introduction For pediatric diseases like childhood leukemia, a short latency period points to in-utero exposures as potentially important risk factors. Untargeted metabolomics of small molecules in archived newborn dried blood spots (DBS) offers an avenue for discovering early-life exposures that contribute to disease risks. Objectives The purpose of this study was to develop a quantitative method for untargeted analysis of archived newborn DBS for use in an epidemiological study (California Childhood Leukemia Study, CCLS). Methods Using experimental DBS from the blood of an adult volunteer, we optimized extraction of small molecules and integrated measurement of potassium as a proxy for blood hematocrit. We then applied this extraction method to 4.7-mm punches from 106 control DBS samples from the CCLS. Sample extracts were analyzed with liquid chromatography high resolution mass spectrometry (LC-HRMS) and an untargeted workflow was used to screen for metabolites that discriminate population characteristics such as sex, ethnicity, and birth weight. Results Thousands of small molecules were measured in extracts of archived DBS. Normalizing for potassium levels removed variability related to varying hematocrit across DBS punches. Of the roughly 1,000 prevalent small molecules that were tested, multivariate linear regression detected significant associations with ethnicity (3 metabolites) and birth weight (15 metabolites) after adjusting for multiple testing. Conclusions This untargeted workflow can be used for analysis of small molecules in archived DBS to discover novel biomarkers, to provide insights into the initiation and progression of diseases, and to provide guidance for disease prevention.

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Section: Resultsmentioning

confidence: 99%

An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies

et al. 2017

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“…The children who born small for gestational age and at higher risk to develop T2DM later in adulthood, showed higher GH secretion indicating that GH has an important role to stimulate intrauterine growth along with other growth promoting factors (104). GH treatment in those children induced catch-up growth and increased their adult heights (105).…”

Section: Acknowledgementsmentioning

confidence: 99%

Evaluation of Pharmacological Modification of Growth Hormone Secretagogue Receptor in a Mouse Model of Non-Obese Type 2 Diabetes Mellitus

Mosa¹,

Mofeed²

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While it appears that obesity is associated with the higher incidence of type 2 diabetes mellitus (T2DM), recent findings that T2DM affects non-obese people are becoming more noticeable. Many of those who are not obese by traditional weight measurements have an increased percentage of body fat distributed predominately in the abdominal and visceral regions. Disorders of lipid metabolism play a major role in the pathogenesis of this nonobese diabetic phenotype. For examples, lipodystrophic patients develop insulin resistance due to insufficient adipose tissue and aged lean people with diabetes have defects in mitochondrial lipid oxidative mechanisms. Such non-obese diabetic patients are at increased risk of developing cardiovascular (CVD) complications. The management of non-obese T2DM should focus not only on life style modifications or blood glucose control but also strategies for correction of lipid metabolic aberrations. Growth hormone (GH) exerts powerful influences on growth and body composition. In obese animal models and human, GH is known to correlate inversely with insulin concentrations. Some studies suggest that insulin may have a direct inhibitory effect on GH secretion, whereas others showed that insulin inhibits GH secretion via suppression of growth hormone releasing hormone (GHRH) or stimulation of somatostatin (SST). Although GH-insulin relationship is well documented in obesity, studies of this GH-insulin relationship in non-obese diabetes are sparse and contradictory. Thus, this study aimed to investigate the pulsatile GH profile and its regulatory factors in MKR mice which are non-obese diabetic mice generated by igf-1 receptor mutation in skeletal muscle. Our observations demonstrated that unlike obese mice, MKR mice had normal to higher pulsatile GH secretion at different age groups. Nevertheless, there were no detectable changes in gene expressions of hypothalamic GHRH and SST. Interestingly, hypothalamic orexigenic NPY gene expression was increased that might affect GH secretion. These findings suggest that the relationship between GH and insulin was altered in MKR mice, leading to higher GH concentrations despite hyperinsulinaemia. Given that MKR mice exhibited postnatal growth retardation, we anticipated that endogenous GH levels would increase to facilitate rapid linear growth and promote muscle development that assist nutrient uptake and utilization.Therapy using growth hormone secretagogues (GHS) that increase endogenous GH secretion through binding to the ghrelin receptor (GHS-R1a) might have beneficial effects on lipid metabolism with less adverse effects on glucose metabolism than exogenous GH administration. Recent studies have provided some interesting avenues for further exploration on how Hexarelin, one of synthetic peptide GHS, enhanced fat metabolism of white adipose tissue (WAT) via CD36 activation independently of GHS-R1a. To address the effects of Hexarelin in non-obese diabetes, MKR were received daily intraperitoneal (I.P.) injection of Hexarelin (200ug/kg body ...

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Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

Ren,

Xia,

et al. 2024

Neuron

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Growth hormone levels in relation to birth weight and gestational age

Cited by 3 publications

References 14 publications

An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies

An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies

Evaluation of Pharmacological Modification of Growth Hormone Secretagogue Receptor in a Mouse Model of Non-Obese Type 2 Diabetes Mellitus

Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

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