Growth Hormone Levels in Slipped Capital Femoral Epiphysis

Razzano, Cristina; Nelson, Carl H.; Eversman, John J.

doi:10.2106/00004623-197254060-00009

Cited by 28 publications

(7 citation statements)

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“…All plasma and urinary hormone levels in patients with SCFE were similar to controls. Also, pubertal development was normal and comparable to the controls [50–53].…”

Section: Resultsmentioning

confidence: 74%

Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: A systematic review of the literature

Witbreuk

Kemenade

Sluijs

et al. 2013

Journal of Children's Orthopaedics

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Purpose Puberty, obesity, endocrine and chronic systemic diseases are known to be associated with slipped capital femoral epiphysis (SCFE). The mechanical insufficiency of the physis in SCFE is thought to be the result of an abnormal weakening of the physis. However, the mechanism at the cellular level has not been unravelled up to now. Methods To understand the pathophysiology of endocrine and metabolic factors acting on the physis, we performed a systematic review focussing on published studies reporting on hormonal, morphological and cellular abnormalities of the physis in children with SCFE. In addition, we looked for studies of the effects of endocrinopathies on the human physis which can lead to cause SCFE and focussed in detail on hormonal signalling, hormone receptor expression and extracellular matrix (ECM) composition of the physis. We searched in the PubMed, EMBASE.com and The Cochrane Library (via Wiley) databases from inception to 11thSeptember 2012. The search generated a total of 689 references: 382 in PubMed, 232 in EMBASE.com and 75 in The Cochrane Library. After removing duplicate papers, 525 papers remained. Of these, 119 were selected based on titles and abstracts. After excluding 63 papers not related to the human physis, 56 papers were included in this review. Results Activation of the gonadal axis and the subsequent augmentation of the activity of the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis are important for the pubertal growth spurt, as well as for cessation of the physis at the end of puberty. The effects of leptin, thyroid hormone and corticosteroids on linear growth and on the physis are also discussed. Children with chronic diseases suffer from inflammation, acidosis and malnutrition. These consequences of chronic diseases affect the GH-IGF-1 axis, thereby, increasing the risk of the development of SCFE. The risk of SCFE and avascular necrosis in children with chronic renal insufficiency, growth hormone treatment and renal osteodystrophy remains equivocal. Conclusions SCFE is most likely the result of a multifactorial event during adolescence when height and weight increase dramatically and the delicate balance between the various hormonal equilibria can be disturbed. Up to now, there are no screening or diagnostic tests available to predict patients at risk.

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“…All plasma and urinary hormone levels in patients with SCFE were similar to controls. Also, pubertal development was normal and comparable to the controls [50–53].…”

Section: Resultsmentioning

confidence: 74%

Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: A systematic review of the literature

Witbreuk

Kemenade

Sluijs

et al. 2013

Journal of Children's Orthopaedics

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“…Patients with SCFE show a great variety of presentations and symptoms. Even if a common presentation is that of an obese, hypogonadal boy during adolescent growth, most SCFE cases show no associated endocrinal disorder 13,14. The most commonly adopted classification divides SCFE into “stable” or “unstable” cases and is based on the ability of the patient to walk.…”

Section: Etiology and Histopathologymentioning

confidence: 99%

<p>Slipped capital femoral epiphysis: current management strategies</p>

Aprato

Conti²,

Bertolo³

et al. 2019

ORR

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In orthopedic literature, there is little consensus regarding the best management of slipped capital femoral epiphysis (SCFE). Controversies and disparate trends derive from differences in clinical presentation, various classifications, and a variety of surgical procedures that have been described. Currently, there are no evidence-based recommendations. Surgical procedures vary, and they can be divided into fixation in situ, compensatory osteotomies, and direct corrections of the deformity at the head–neck junction. The first and second group of procedures have so far not gained optimal control over the risk of avascular necrosis or cannot achieve an anatomically aligned epiphysis with normal blood supply. On the other hand, the third technique can achieve this target and prevent residual deformity and the development of early hip arthritis, but it is not widely accepted, because of its surgical complexity. The purpose of this work is to present an overview of current knowledge and provide an orientation on clinical and surgical management of the patient suffering from SCFE.

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“…Biochemically, human GH was first noted to be critical for normal physeal function by Harris, who demonstrated a decrease in physeal shearing strength in the presence of GH, with an inverse relationship to exposure to sex hormones 40 . The role of GH imbalance in the pathogenesis of SCFE is not universally accepted and has been challenged by others 41 . Despite this, there are a number of case reports and series reporting the development of SCFE in patients with GH deficiency 40,42 as well as those with hypogonadism, including Turner syndrome, Klinefelter syndrome, and others 43-45 .…”

Section: Endocrinopathies Associated With Scfementioning

confidence: 99%

“…Children undergoing growth hormone therapy who present with hip pain should be evaluated for an SCFE 31,[39][40][41][42] .…”

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confidence: 99%

Slipped Capital Femoral Epiphysis Associated with Endocrinopathy

et al. 2022

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Slipped capital femoral epiphysis (SCFE) has a well-documented association with underlying endocrine conditions, including thyroid hormone aberrations and parathyroid dysfunction.Recombinant growth hormone therapy has also been identified as a risk factor for the development of SCFE.Presentation before their 10th birthday or after their 16th birthday along with height of <10th percentile are reliable risk factors for identifying children with an SCFE who are at a heightened risk for an underlying endocrinopathy and can been used to guide selective laboratory testing.Patients with unilateral SCFE presentations with an underlying endocrinopathy are at a heightened risk for contralateral slip development and should be treated with prophylactic fixation.

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Growth Hormone Levels in Slipped Capital Femoral Epiphysis

Cited by 28 publications

References 0 publications

Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: A systematic review of the literature

Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: A systematic review of the literature

<p>Slipped capital femoral epiphysis: current management strategies</p>

Slipped Capital Femoral Epiphysis Associated with Endocrinopathy

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