Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

“…In the current study, we investigated the phenotype of mice carrying inactivation of the mTORC1 pathway exclusively in AgRP-expressing cells. Considering the role of mTORC1 signaling in nutrient sensing [11,14] and the importance of AgRP neurons in triggering metabolic adaptations in situations of negative energy balance [10,23,26,36,37], we hypothesized that AgRP ΔRaptor mice may not exhibit a complete metabolic response to food restriction. In accordance with a previous study [22], ad libitum fed AgRP ΔRaptor mice exhibited no major alterations in energy homeostasis.…”

“…Previous studies indicate the critical role of AgRP neurons in energy conservation [2], particularly during situations of food restriction [10,23,26,36,37]. To investigate whether mTORC1 signaling in AgRP neurons is required to induce major neuroendocrine adaptations during conditions of negative energy balance, control and AgRP ∆Raptor mice were subjected to 5 days of food restriction (40% of their basal food intake), followed by 5 days of ad libitum refeeding.…”

Editorial: Endocrine regulation of aging: impacts of humoral factors and circulating mediators

“…This synergy is pivotal in decoding the complexities of how hormonal balances and shifts influence the aging process, offering essential insights into the fundamental underpinnings of longevity and age-associated diseases ( 1 – 3 ). The focus of the Research Topic “ Endocrine Regulation of Aging: Impacts of Humoral Factors and Circulating Mediators ” is on highlighting the critical role of hormonal and circulating factors in influencing the aging process ( 4 – 6 ). This editorial compiles novel research articles that investigate the diverse roles of endocrine pathways, humoral factors, and circulating mediators in modulating the physiological aspects of aging.…”