Growth hormone release inhibiting hormone: actions on thyrotrophin and prolactin secretion after thyrotrophinreleasing hormone.

Carr, Denis H.; Gómez-Pan, A.; Weightman, D.; Roy, van; Hall, R.; Besser, G. M.; Thorner, Michael O.; McNeilly, A. S.; Schally, Andrew V.; Kastin, A. J.; Coy, David H.

doi:10.1136/bmj.3.5975.67

Cited by 57 publications

(14 citation statements)

References 15 publications

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“…The levels in craniopharyngiomas are to be contrasted with the findings in pituitary adenomas, where we and others (17) have found that the prolactin values are increased in approximately 70% of cases, often to a very high degree, and in these patients, active secretion of prolactin by the tumor itself appears to take place. The absence of any consistent relationship between the prolactin and TSH response to TRH indicates that the secreting cells have different sensitivities to TRH, and there is evidence that the release mechanisms for the two hormones are quite separate (18).…”

Section: Discussionmentioning

confidence: 98%

Hypothalamic-Pituitary Function in Patients with Craniopharyngiomas

Jenkins¹,

Gilbert²,

Ang³

1976

The Journal of Clinical Endocrinology & Metabolism

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Hypothalamic-pituitary function was investigated in 20 patients with craniopharyngioma, and all showed some degree of hypopituitarism. Pituitary-adrenal dysfunction was present in 50% of the patients whereas all but one had deficiencies of growth hormone and gonadotropin. Serum thyroxine was low in 13 patients, and in a further six there was an abnormal response of thyrotropin (TSH) to thyrotropin-releasing hormone (TRH). Prolactin levels were normal in over half the patients tested and only moderately elevated in the remainder. Gonadotropins failed to increase adequately after gonadotropin-releasing hormone (LRH) in all but one patient, and the response gave no indication of the predominantly hypothalamic site of the tumors.

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Section: Discussionmentioning

confidence: 98%

Hypothalamic-Pituitary Function in Patients with Craniopharyngiomas

Jenkins¹,

Gilbert²,

Ang³

1976

The Journal of Clinical Endocrinology & Metabolism

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“…It was also reported that GH may influence the TRH mediated secretion of TSH (Root et al, 1973). While somatostatin inhibited TSH secretion by TRH in normal people and in patients with primary hypothyroidism (Carr et al, 1975), the possibility of the participation of somatostatin in the regulation not only of GH but TSH serection in case of TRH administration should also be considered.…”

Section: Synopsismentioning

confidence: 99%

Increase of serum GH concentration following TRH injection in patients with primary hypothyroidism.

Hamada¹,

Uoi²,

Nishizawà³

et al. 1976

Endocrinol Japon

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SynopsisThe effect of TRH administration on serum GH was studied in 6 normal subjects, 13 patients with primary hypothyroidism and 6 thyrotoxic subjects. Although no appreciable changes of serum GH were noted in the normal subjects, TRH administration provoked an increase of serum GH in 6 out of 13 patients with primary hypothyroidism.Serum GH levels in response to TRH administration were decreased in patients who were euthyroid following treatment with a preparation of desiccated thyroid.In patients with hyperthyroidism, no significant response of serum GH was observed at 30 or 60 min after TRH administration.Some of the patients with hyperthyroidism showed a slight increase in serum GH at 120 min after TRH injection.These results suggest that hypothalamo-pituitary function regulating GH secretion is altered in patients with primary hypothyroidism.

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“…As far as growth hormone (GH) release is concerned somatostatin has, indeed, been shown to be an effective inhibitor in a number of species (rat, dog, baboon, man) independently of the agents used for stimulation of the secretion (arginine, L-dopa, barbiturates, chlorpromazine, exercise, sleep, meals, catecholamines, insulin hypoglycemia) [12,43,85,89,98,53,66,73,79,108,40,56]. This inhibitory action of somatostatin on the release of pituitary hormones seems also to include TSH [105,98,17].…”

Section: On Endocrine Functionsmentioning

confidence: 99%