Growth hormone replacement improved oocyte quality in a patient with hypopituitarism: A study of follicular fluid

Scheffler, Florence; Cabry, Rosalie; Soyez, Marion; Copin, Henri; Khalifa, Moncef Ben; Devaux, A.; Desailloud, Rachel

doi:10.1016/j.ando.2021.05.003

Cited by 7 publications

(5 citation statements)

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“…Our results are consistent with Giampietro who was the first to report GHRT as an effective treatment of infertility in four eugonadal women with GHD, thus avoiding the need of ovarian stimulation (13). Another publication by Scheffler reported an increase of GH concentration in the follicular fluid and improvement in oocyte quality (no abnormal morphologies) and in embryo quality (grade A) in a woman after the addition of GHRT during IVF procedure, allowing an embryo transfer with subsequent successful pregnancy (30). Pregnancy losses were also less frequent in our GHRT group (1 miscarriage out of 8 total pregnancies vs 4 miscarriages out of 16 total pregnancies in the group without GHRT), and we found no other data in the published literature.…”

Section: Discussionsupporting

confidence: 90%

Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy

Dubreuil

Touraine

2022

Endocrine Connections

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Objective: Growth hormone (GH) and insulin-like growth factors (IGFs) are not mandatory for reproductive life, but data suggest their synergistic action with follicle stimulating hormone (FSH) throughout ovarian folliculogenesis. We aimed to evaluate the association of IGF-I level on clinical pregnancy rate after ovarian stimulation, with or without intra-uterine insemination, in women with GH deficiency treated with GH replacement therapy at conception. Design and Methods: Data from 19 women with both GH deficiency and hypogonadotropic hypogonadism referred to our reproductive medicine department, were retrospectively collected. IGF-I levels were assessed in a single laboratory, values were expressed in standard deviations (SD) from the mean. Results: Amongst the 7 patients receiving GH replacement therapy during ovarian stimulation, higher IGF-I level was significantly associated with clinical pregnancy (+0.4 SD vs -1.6 SD, p=0.03). Amongst the 24 pregnancies obtained by the 19 infertile patients, pregnancy loss was less frequent with the addition of GH replacement therapy, than without (1 miscarriage out of 8 total pregnancies, vs 4 miscarriages out of 16 total pregnancies). Conclusions: This is the first study evaluating the association of IGF-I level on clinical pregnancy rate, in GH-treated women at conception. When taking care of female infertility due to hypogonadotropic hypogonadism, practitioners should enquire about associated GH deficiency and IGF-I level. To ensure higher clinical pregnancy chances, practitioners should aim for IGF-I values at conception ranging from 0 SD to +2 SD, and if necessary, could discuss initiation or increase GH treatment. Prospective studies should help strengthen our results.

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Section: Discussionsupporting

confidence: 90%

Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy

Dubreuil

Touraine

2022

Endocrine Connections

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“…The positive effects of GH supplementation on ovarian stimulation in women with GH deficit (GHD) have not been extensively studied [34]. It was shown through IVF that GH enhanced the activity of low dosages of FSH, hence boosting the content of LH receptors.…”

Section: Resultsmentioning

confidence: 99%

Investigate the Correlation of Growth Hormone with the Level of Some Reproductive Hormones and Certain Parameters in a Number of Iraqi-Aging and Younger Women During IVF/ICSI Cycles

kadhim,

Salih

2023

Kirkuk J. Sci.

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An estimated 12-20% of couples struggle with infertility, It is described as not becoming pregnant after a year of trying. About one-third of these couples are infertile because of female factors, and another third are infertile because of male factors. A combination of the two may be experienced by couples in the remaining one-third. Its distributed into two groups, primary and secondary. A total of 60 participants, 30 of whom were older women (>35) and 30 of whom were younger women (<35). In this study the results were showed statistically highly significant positive correlation-r between GH and both serum and follicular fluid (FF) FSH (0.84, 0.81 mIU/ML), LH (0.76, 0.74 mIU/ML) and AMH (0.89, 0.86 mIU/ML), and there was highly significant positive correlation between GH and number of retrieval Oocyte (0.47, 0.46 mIU/ML), negatively significant correlation was found between GH and number of abortion (-0.10, -0.14 mIU/ML). Notably, the vast majority of the assessments GH hormone levels in serum and follicular fluid revealed a statistically significant positive correlation with FSH, LH, AMH, the frequency of miscarriages, the retrieval of oocytes and infertility duration. These findings imply a strong positive correlation between GH and female fertility. As a result, much research is required to assess, estimate the importance of GH levels on women's fertility, and to get an early hormone level assessment before beginning a GH-containing therapy program.

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“…Furthermore, the assessment of oocyte morphological abnormalities in women with hormonal deficit might be informative. Indeed, we have observed a dramatic reduction in the number of oocyte morphological abnormalities after GH replacement therapy in patient with GH deficiency (63). However, this type of study would not be ethically possible in women with hypothyroidism because the establishment of euthyroidism in pregnancy is clinically necessary.…”

Section: Discussionmentioning

confidence: 98%

Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study

et al. 2021

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IntroductionOocyte quality contributes to the development of an optimal embryo and thus a successful pregnancy. The objective of this study was to analyse the association between oocyte cohort quality and the follicular levels of growth hormone (GH), insulin-like growth factor 1 (IGF1), 25-hydroxy vitamin D (25OHD), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and antithyroid antibodies, as a function of intracytoplasmic sperm injection (ICSI) outcomes.Material and methodsWe conducted a prospective comparative pilot study from January 2013 to December 2017. 59 ICSI cycles constituted an abnormal oocyte cohort (n=34 cycles, in which more than 50% of oocytes presented at least one morphological abnormality) and a normal oocyte cohort (n=25 cycles, in which 50% or less of the oocytes presented at least one morphological abnormality). GH, IGF1, 25OHD, TSH, fT3, fT4 and antithyroid antibodies were measured in follicular fluid.ResultsThe fertilisation rate was lower in the abnormal oocyte cohort (65.5% vs. 80%, respectively, p=0.012). Oocytes’ proportion with at least one abnormality was 79.4% in the abnormal oocyte cohort and 29.0% in the normal oocyte cohort. The mean number of morphological abnormalities per oocyte was significantly higher in the abnormal oocyte cohort. The follicular levels of GH (4.98 vs. 2.75 mIU/L, respectively; p <0.01) and IGF1 (72.1 vs. 54.2 ng/mL, respectively; p=0.05) were higher in the normal oocyte cohort. There was no association with follicular levels of TSH, fT3, fT4, antithyroid antibodies, or 25OHD.ConclusionOocyte cohort quality appears to be associated with follicular levels of GH and IGF1.

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Growth hormone replacement improved oocyte quality in a patient with hypopituitarism: A study of follicular fluid

Cited by 7 publications

References 50 publications

Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy

Normal-high IGF-1 level improves pregnancy rate after ovarian stimulation in women treated with growth hormone replacement therapy

Investigate the Correlation of Growth Hormone with the Level of Some Reproductive Hormones and Certain Parameters in a Number of Iraqi-Aging and Younger Women During IVF/ICSI Cycles

Follicular GH and IGF1 Levels Are Associated With Oocyte Cohort Quality: A Pilot Study

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