2007
DOI: 10.1007/s12020-007-0018-7
|View full text |Cite
|
Sign up to set email alerts
|

Growth hormone reserve in adult beta thalassemia patients

Abstract: Reduced serum insulin-like growth factor-1 (IGF-1) and hypogonadotrophic hypogonadism are common features of adult beta-thalassemia, and warrant evaluation of the growth hormone (GH)-IGF-1 axis. The aim of this study was to determine GH reserve in beta-thalassemia patients (9 females, 7 males, 15 major, 1 intermedia), age 29.3 +/- 6.9 years, BMI 21.3 +/- 1.9 kg/m2, and in 20 age, sex and BMI-matched healthy controls, using the GH-releasing hormone (GHRH)-arginine test. The associations between peak GH response… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
18
0

Year Published

2010
2010
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(19 citation statements)
references
References 29 publications
1
18
0
Order By: Relevance
“…Serum parameters of group 2 of patients with BTM, in our study were insignificantly different from their control group 4 except as regard serum ferritin; this ferritin was accused in several studies before to be the cause of short stature and decreased their serum levels of IGF-1 and its binding protein IGFBP-3. 16 In our study there was no correlation between serum ferritin and any other variable of the patients with BTM, the result which agreed with that of Karydis et al 2004 21 and that of Vedergor et al 2007, 22 who found no significant correlation between serum ferritin and the peak levels of GH or IGF1. In our study there was a statistically significant correlation between T4 and upper/lower segment ratio, this result could be explained by the known effect of thyroid hormone on the body proportions.…”
supporting
confidence: 90%
“…Serum parameters of group 2 of patients with BTM, in our study were insignificantly different from their control group 4 except as regard serum ferritin; this ferritin was accused in several studies before to be the cause of short stature and decreased their serum levels of IGF-1 and its binding protein IGFBP-3. 16 In our study there was no correlation between serum ferritin and any other variable of the patients with BTM, the result which agreed with that of Karydis et al 2004 21 and that of Vedergor et al 2007, 22 who found no significant correlation between serum ferritin and the peak levels of GH or IGF1. In our study there was a statistically significant correlation between T4 and upper/lower segment ratio, this result could be explained by the known effect of thyroid hormone on the body proportions.…”
supporting
confidence: 90%
“…Similar high prevalence of GH deficiency was reported by others. [34567] Peak GH to provocation by clonidine correlated well with IGF-I concentrations and therefore seems to be effective. The absence of significant side-effects in 30 adults with TM suggests its safe use in adults.…”
Section: Discussionmentioning
confidence: 97%
“…Recent studies have demonstrated the necessity to evaluate adult patients affected by TM to establish the presence of GH-IGF-I alteration which could be relevant in the pathogenesis of bone disease and cardiac dysfunction frequently present in this haemoglobinopathy. [34567]…”
Section: Introductionmentioning
confidence: 99%
“…This coincides with the results of Vidergor et al . [18] and Moayeri and Oloomi [14], who reported that GHD in thalassaemic patients was 25 and 38% respectively. On the other hand, it was higher than that reported by De Sanctis et al .…”
Section: Discussionmentioning
confidence: 99%
“…Low IGF-1 in normal growth hormone responders has led to the speculation of complete or partial growth hormone insensitivity syndrome (GHIS) rather than GHD as the most likely cause of their growth retardation [3, 18, 21]. …”
Section: Discussionmentioning
confidence: 99%