Growth Hormone Response to Insulin Hypoglycemia in the Elderly

Kalk, W. J.; Vinik, A; Pimstone, B. L.; Jackson, WE

doi:10.1093/geronj/28.4.431

Cited by 57 publications

(25 citation statements)

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“…This study con firms an earlier investigation which examined L-dopastimulated GH secretion and found a similar response in young and old subjects [50]. Other investigations have found that the GH response to insulin-induced hypogly cemia remains intact with age [51],…”

Section: Discussionsupporting

confidence: 89%

Dopaminergic Regulation of Gonadotropin and Thyrotropin Hormone Secretion Is Altered with Age

Greenspan

Sparrow

1991

Horm Res

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To determine if age-related changes in glycoprotein pituitary hormone secretion are associated with alterations in dopaminergic regulation, plasma gonadotropins and TSH were measured before and after L-dopa administration in 44 young (31–44 years of age) and 42 old (64–88 years of age) healthy male participants. Plasma GH and PRL were also determined in order to examine the somatotroph and lactotrope response. In the young, following L-dopa, plasma FSH, LH and TSH were unchanged from baseline. However, in older subjects, plasma FSH was significantly increased (p < 0.001) and a similar trend was noted for LH. Plasma TSH was significantly depressed (p < 0.002) in older subjects only. Following L-dopa, increases in plasma GH and decreases in plasma PRL were of similar magnitude in each group. These data indicate that dopaminergic modulation of gonadotropins and TSH is altered with age.

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Section: Discussionsupporting

confidence: 89%

Dopaminergic Regulation of Gonadotropin and Thyrotropin Hormone Secretion Is Altered with Age

Greenspan

Sparrow

1991

Horm Res

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“…The ITT is contraindicated in adults with ischaemic heart disease, so most authors currently suggest it should not be used in adults over the age of 60 years as the risk of occult ischaemic heart disease is unacceptable. The ITT was however previously evaluated across the adult lifespan and the GH response to insulin-induced hypoglycaemia was not affected by age in some studies [76] while others observed a reduced GH response in the elderly [77]. Similar confusion exists when other GH secretagogues are used in the elderly.…”

Section: Dynamic Gh Secretionmentioning

confidence: 99%

Aging and the growth hormone/insulin like growth factor-I axis

Sherlock

Toogood

2007

Pituitary

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Growth hormone release and IGF-I synthesis decrease with increasing age. The regulation of the GH/IGF-I system is dependent on the integrity of the hypothalamus, pituitary and liver. During aging there are several changes which contribute to the decline in GH/IGF-I including changes in signal to the somatotrophs from growth hormone releasing hormone, somatostatin and other factors such as body composition, exercise, diet and sleep. All of these factors are discussed in detail within this review. The phenotypic similarities between aging and adult growth hormone deficiency syndrome combined with this decrease in GH/IGF-I with aging have prompted the question whether aging is a GH deficient state. The advent of recombinant growth hormone has led to a number of studies treating elderly patients with GH alone or in combination with sex steroids or exercise. The results of these studies would not back up the use of GH in elderly non-hypopituitary patients as they did not show efficacy, showed high rates of adverse events and there is also some evidence associating GH/IGF-I and risk of neoplasia. If GH therapy is to be used in this cohort of patients further long term efficacy and safety studies are required.

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“…In a study by Dudl et al [14], the GH response to arginine did not diminish with aging. The response to GH-releasing hormone is reported to be unchanged [15] or reduced [16], and the response to insu lin-induced hypoglycaemia has also been variably re ported as unchanged [17] or reduced [18]. These discor dant findings are difficult to reconcile but probably reflect the failure to control for modulating factors such as obe sity.…”

Section: Introductionmentioning

confidence: 99%

Aging and Growth Hormone

Hoffman

1993

Horm Res

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Detailed studies of the ontogeny of growth hormone (GH) secretion have shown unequivocally that GH is produced throughout life but secretion declines progressively to about 20% of that in puberty. These changes are accounted for in part by changes in central neuro-endocrine function, nutritional factors and by changes in sex steroid milieu. Mean 24-hour GH concentrations in the normal elderly are frequently below the limit of assay detectability where values are indistinguishable from matched adults with organic GH deficiency. The notion that diminished GH action may account for the undesirable changes in body composition and function in the elderly is supported by beneficial findings of GH treatment in GH-deficient adults. Preliminary results of GH treatment in the normal elderly suggest beneficial effects on body composition but a high incidence of side-effects. Questions addressing cost, benefit, dosage, safety and tolerance need to be critically addressed before GH can be considered for use in the aging.

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Growth Hormone Response to Insulin Hypoglycemia in the Elderly

Cited by 57 publications

References 0 publications

Dopaminergic Regulation of Gonadotropin and Thyrotropin Hormone Secretion Is Altered with Age

Dopaminergic Regulation of Gonadotropin and Thyrotropin Hormone Secretion Is Altered with Age

Aging and the growth hormone/insulin like growth factor-I axis

Aging and Growth Hormone

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