1996
DOI: 10.1046/j.1365-2265.1996.713534.x
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Growth hormone responses to growth hormone‐releasing hormone and clonidine in patients with type I diabetes and in normal controls: effect of age, body mass index and sex

Abstract: Patients with moderately controlled type I diabetes mellitus have normal baseline and stimulated GH concentrations after the administration of GHRH or clonidine compared with healthy controls, when corrected for age, body mass index and sex. However, these 'normal' GH concentrations must be considered inappropriately high in view of the hyperglycaemia in these patients. The low plasma IGF-I concentrations might be responsible for the GH over-production.

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Cited by 9 publications
(6 citation statements)
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“…Type 1 diabetic patients were shown to exhibit elevated GH levels and exaggerated GH response to GHRH (46,47), which in turn may contribute to dyslipidemia (48). Besides stimulating GH production in the pituitary gland, GHRH also exerts peripheral effects through full-length pituitary type receptors and splice variant 1 receptors that are expressed in various organs, including lung, heart, stomach, small intestine, colon, and kidney (22)(23)(24).…”
Section: Mia-602 Improves Vascular Function In T1dmentioning
confidence: 99%
“…Type 1 diabetic patients were shown to exhibit elevated GH levels and exaggerated GH response to GHRH (46,47), which in turn may contribute to dyslipidemia (48). Besides stimulating GH production in the pituitary gland, GHRH also exerts peripheral effects through full-length pituitary type receptors and splice variant 1 receptors that are expressed in various organs, including lung, heart, stomach, small intestine, colon, and kidney (22)(23)(24).…”
Section: Mia-602 Improves Vascular Function In T1dmentioning
confidence: 99%
“…glucose load. In insulin-dependent diabetes mellitus, however, this correlation is absent (16) and GHRHstimulated GH secretion is considered inappropriately high in view of the hyperglycaemia in these patients. The heterogeneity in the GH response to GHRH is greater in diabetes mellitus than in healthy individuals, and the response depends on the degree of metabolic alteration.…”
Section: Non-insulin-dependent Diabetes Mellirusmentioning
confidence: 99%
“…It is unclear, however, whether this inhibition of GH secretion is caused by the blood glucose level itself or by the secondary rise in insulin levels. In patients with diabetes, GH levels are abnormally high and the response to GH stimuli is exaggerated, suggesting a central derangement caused by glucose levels, FFA, IGF‐1 or insulin 17–19 . In patients with diabetes, an elevated set point for the reactivity to blood glucose levels of the pituitary‐adrenal axis has been described either as a consequence or a cause of deranged carbohydrate metabolism or insulin insensitivity 20 …”
Section: Introductionmentioning
confidence: 99%
“…In patients with diabetes, GH levels are abnormally high and the response to GH stimuli is exaggerated, suggesting a central derangement caused by glucose levels, FFA, IGF-1 or insulin. [17][18][19] In patients with diabetes, an elevated set point for the reactivity to blood glucose levels of the pituitary-adrenal axis has been described either as a consequence or a cause of deranged carbohydrate metabolism or insulin insensitivity. 20 Whether the pituitary hormone release in normal subjects is related to blood glucose levels in a situation of normoglycaemia is not clear.…”
Section: Introductionmentioning
confidence: 99%