Growth Hormone Responses to Sleep, Insulin Hypoglycaemia and Arginine Infusion

Ward, Paul; Savage, D. C. L.

doi:10.1159/000180065

Cited by 4 publications

(2 citation statements)

References 12 publications

(19 reference statements)

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“…It is well known that ITT results in higher peak GH responses compared to most other classic tests ( Ward & Savage, 1985; Tapanainen et al ., 1988 ; Rasmussen et al ., 1995 ). It has also been demonstrated that the specificity is poor for the Arg test in adults ( Vahl et al ., 1996 ).…”

Section: Discussionmentioning

confidence: 99%

L‐Arginine and insulin‐tolerance tests in the diagnosis of adult growth hormone deficiency: influence of confounding factors

Fisker

Jørgensen

Ørskov

et al. 1998

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

L‐Arginine and insulin‐tolerance tests in the diagnosis of adult growth hormone deficiency: influence of confounding factors

Fisker

Jørgensen

Ørskov

et al. 1998

Clinical Endocrinology

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“…Secondly, spontaneous GH secre¬ tory episodes do occur in children with various pubertal stages (Greenwood et al, 1964, Finkelstein et al, 1972, Miller et al, 1982. They are present both during the night and waking hours (Hunter & Rigai, 1966, Takahashi et al, 1968, Honda et al, 1969, Parker et al, 1969, Miller et al, 1982, Minuto et al, 1982, Spiliotis et al, 1984, Sanz & Rochiccioli, 1985, Ward & Savage, 1985, Garnier et al, 1985, and daytime pulsatile GH secretory episodes have been clearly documented in prepubertal children. As shown by Miller et al (1982) and by Spiliotis et al (1984), these episodes are more frequent between 08.30 and 09.30 as well as around lunch time, although no clear relationship to meals could be established.…”

Section: Discussionmentioning

confidence: 99%

Growth hormone response to thyrotropin-releasing hormone in children and adolescents: a reappraisal

Theintz

Tang

Marti

et al. 1986

Acta Endocrinologica

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In normal subjects, thyrotropin-releasing hormone (TRH) is not involved in the control of growth hormone secretion. Paradoxical growth hormone (GH) responses to TRH have been described in acromegalic subjects and, recently, in some constitutionnally tall children. To confirm this finding, we have examined the GH response to combined LHRH-TRH tests performed to assess the pituitary function of children with GH deficiency, tall stature before and during bromocriptine therapy, precocious or delayed puberty as well as in a group of patients of average height and normal bone age. Unlike prolactin, the GH "response" to TRH, in children followed longitudinally, is particularly heterogeneous with an unpredictable pattern of secretion in repeated tests. Over 90% of children display peaks of GH (\m=ge\5ng/ml),of which 38% occur twice during the test period. Amplitude and frequency of GH peaks appear to be independent of height, chonological age or bromocriptine therapy. Secretory rate estimated by integrated surface area increases in parallel to sex steroids impregnation. The pattern of GH secretory episodes, the increase in mean GH secretion in parallel to the production of gonadal sex steroids and the failure of bromocriptine to affect GH secretion in constitutionnally tall children allow to speculate that what is measured after TRH injection is normal spontaneous GH rhythm rather than a direct effect of TRH on GH secretion.

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Evaluation of growth hormone in thalassaemic boys with failed puberty: Spontaneous versus provocative test

Chatterjee¹,

Katz²,

Cox

et al. 1993

Eur J Pediatr

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Growth hormone (GH) secretion was determined by evaluating ultradian GH profiles for 12 h and GH responses to insulin stimulated hypoglycaemia (ITT) in 28 stunted boys with beta-thalassaemia major aged 15.2-17.4 years, who presented with pubertal failure (FP). Healthy non thalassaemia prepubertal boys (n = 10) aged 7.5-8.8 years, were studied as controls. All patients had normal responses to ITT with peak GH levels > or = 15 mU/l. Basal GH concentrations (mean +/- sem) (1.65 +/- 0.03 mU/l vs 2.58 +/- 0.27 mU/l; P < 0.05) and the stimulated GH responses (peak GH = 15.4 +/- 0.20 mU/l vs 21.08 +/- 0.78 mU/l; P < 0.001) were significantly lower in the patients with failed puberty than in the controls, indicating that the FP patients had diminished GH reserve and secretory capacity. Moreover, all the GH peak parameters including the maximum spontaneous concentrations (MX-GH) and the area under the GH curve (AUC) were significantly lower in the thalassaemic patients than in the controls (MX-GH = 5.2 +/- 0.21 mU/l vs 20.42 +/- 0.14 mU/l; P < 0.001; AUCb = 421.22 +/- 4.31 mU/l vs 712.20 +/- 3.42 mU/l; P < 0.001). These observations suggest that the thalassaemic patients had endogenous neurosecretory GH deficiency (GHND). Priming with sex steroid did not cause any improvement in the spontaneous or stimulated GH secretory patterns in thalassaemic patients. It was noteworthy that in neither the patients nor the control subjects, was there a significant correlation between the maximum stimulated and the MX-GH concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)

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Growth Hormone Responses to Sleep, Insulin Hypoglycaemia and Arginine Infusion

Cited by 4 publications

References 12 publications

L‐Arginine and insulin‐tolerance tests in the diagnosis of adult growth hormone deficiency: influence of confounding factors

L‐Arginine and insulin‐tolerance tests in the diagnosis of adult growth hormone deficiency: influence of confounding factors

Growth hormone response to thyrotropin-releasing hormone in children and adolescents: a reappraisal

Evaluation of growth hormone in thalassaemic boys with failed puberty: Spontaneous versus provocative test

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