Growth hormone therapy for people with thalassaemia

Abstract

Analysis 1.1. Comparison 1 Growth hormone versus control, Outcome 1 Oral glucose tolerance test sum (mg/dL).. Analysis 1.2. Comparison 1 Growth hormone versus control, Outcome 2 Fasting blood glucose (mg/dL).. .. . Analysis 1.3. Comparison 1 Growth hormone versus control, Outcome 3 Height SD score.. .. .. .. .. Analysis 1.4. Comparison 1 Growth hormone versus control, Outcome 4 Change from baseline in height SD score.. Analysis 1.5. Comparison 1 Growth hormone versus control, Outcome 5 Height velocity (cm/year

Investigation and Management of Endocrinopathies in Thalassaemia Major

“…A single non-randomised trial was eligible, which enrolled 20 Turkish children with beta-thalassaemia major, receiving either daily subcutaneous GH or standard care. It presented tentative evidence that height velocity may be increased with GH, but reported no significant differences in the height standard deviations between groups at the study end-point [28]. Most patients lack the pubertal spurt and have reduced GH peak amplitude [29], hence responses to recombinant human GH therapy is poor when compared with that of children with GH deficiency, idiopathic short stature or Turner Syndrome.…”

“…We have previously published an online Review of Endocrine Disorders in Thalassaemia in 2014 (Open Journal of Endocrine and Metabolic Diseases, 2014, 4, [25][26][27][28][29][30][31][32][33][34]. In this book chapter, we have updated all the latest evidence and discuss current thoughts & details of the multi-system endocrine involvement in Thalassaemia.…”

Iron overload disorders: Growth and gonadal dysfunction in childhood and adolescence

“…79 For growth disorders if GHD is diagnosed, specific treatment with recombinant human growth hormone (rhGH) should be initiated, with gradually increased dosage based on clinical evaluation every 6 months (Table 3). 85,86 Some small trials suggest that a 1-year GH treatment in BTM children may positively impact their growth rate. 85,87,88 In addressing pubertal development, given the potential mixed etiology of DP in patients with HC, treatment strategies for pubertal induction should be carefully chosen.…”

“…85,86 Some small trials suggest that a 1-year GH treatment in BTM children may positively impact their growth rate. 85,87,88 In addressing pubertal development, given the potential mixed etiology of DP in patients with HC, treatment strategies for pubertal induction should be carefully chosen. Initiating puberty at the appropriate time is crucial to induce secondary sex characteristics, normal bone mineral density, and ensure proper social, sexual, and psychological development.…”