Growth hormone therapy of Turner's syndrome: Beneficial effect on adult height

Rosenfeld, Ron G.; Attie, K M; Frane, James W.; Brasel, Jo Anne; Burstein, Stephen; Cara, José; Sd, Chernausek; Gotlin, Ronald W.; Kuntze, Joyce; Lippe, Barbara M.; Mahoney, C. Patrick; Moore, Wayne V.; Saenger, Paul; Johanson, Ann J.

doi:10.1016/s0022-3476(98)70452-4

Cited by 242 publications

(178 citation statements)

References 12 publications

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“…Increases in height can be expected from hGH due to its pharmacological action, and there are many reports on hGH treatment in many countries. In particular, Rosenfeld et al reported that an increase of 10.3 ± 4.7 cm in height was achieved by hGH treatment in combination with anabolic steroid treatment [4].…”

Section: Discussionmentioning

confidence: 99%

Low-dose Growth Hormone Treatment (0.175 mg/kg/week) for Short Stature in Patients with Turner Syndrome: Data from KIGS Japan

et al. 2006

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Abstract. Turner syndrome is a common sex chromosome anomaly. Human growth hormone (hGH) is effective for treating short stature, which is a major characteristic of the disease. In this report, we analyzed the results of low-dose GH treatment for short stature in 212 Turner syndrome patients with growth hormone deficiency. These patients were enrolled in KIGS Japan. After 5 years of treatment, change in height was more than the mean growth curve in many patients, and the standard deviation (SD) for stature improved by +1.22 SDS. As the treatment progressed, the weight-for-height index (WHI) decreased in patients aged 8.1 years or older but not more than 14.8 years at the commencement of the treatment.

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Section: Discussionmentioning

confidence: 99%

Low-dose Growth Hormone Treatment (0.175 mg/kg/week) for Short Stature in Patients with Turner Syndrome: Data from KIGS Japan

et al. 2006

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“…In past years it had been demonstrated that, in childhood, GH treatment with doses higher than those employed in GH deficiency can improve adult height (AH) in these patients (1,2,3). Therefore, it was widely accepted for many years that children with TS should be regularly treated with GH.…”

Section: Introductionmentioning

confidence: 99%

Adult height in girls with Turner syndrome treated from before 6 years of age with a fixed per kilogram GH dose

Wasniewska¹,

Aversa

Mazzanti

et al. 2013

European Journal of Endocrinology

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Objective: To evaluate adult height (AH) in 25 girls with Turner syndrome (TS) who were treated from before 6 years of age for 10.0G1.7 years with a fixed GH dose of 0.33 mg/kg per week. Patients and design: After a 6-month pretreatment assessment all patients were measured 6-monthly under therapy to assess height SDS (H-SDS) and height velocity (HV) until AH achievement. Results: Following initial acceleration, HV declined after the first 4 years of therapy. At the end of the sixth year of therapy, H-SDS gain was 1.9G1.1. Thereafter, H-SDS gain from baseline decreased, becoming 0.9G0.9 SDS at AH achievement. Bone maturation velocity did not significantly change throughout the prepubertal period. According to Lyon standards for TS, mean AH SDS was significantly higher than pretreatment H-SDS (P!0.0001), with a mean H-SDS change of 0.9G0.9. However, the prevalence of patients with AH !K2 SDS (according to Sempé standards) was close to those recorded at the start of therapy (16/25 vs 18/25). No significant differences in terms of AH were found between patients with either X monosomy or X-chromosomal abnormalities and between girls with either spontaneous or induced puberty. Conclusions: We infer that the therapeutic regimen adopted in this prospective study is sufficient to induce a significant growth acceleration during the first year, but the response waned after 6 years of treatment.

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“…Contudo, os parâmetros como idade cronológica, idade óssea, dose utilizada e tempo de tratamento eram variados. Assim, os dados de estatura final eram bastante díspares (11,17,18,35). Naeraa e cols.…”

Section: Discussionunclassified

“…(19), Rosenfeld e cols. (17) e adotada como protocolo deste estudo? Como descrito anteriormente, o GH é fornecido gratuitamente às pacientes pela Secretaria de Estado da Saúde do Paraná e esse fato dificulta o uso de doses maiores como 0,66 mg/kg/semana utilizada por Sas (12).…”

Section: Discussionunclassified

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Estatura final (EF) em síndrome de Turner (ST): experiência de 76 casos acompanhados na Unidade de Endocrinologia Pediátrica do Hospital de Clínicas da Universidade Federal do Paraná

Fonteles¹,

Dondoni²,

Boguszewski³

et al. 2011

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Relatar estatura final (EF) em 76 pacientes com síndrome de Turner (ST). Materiais e métodos: Revisão de prontuários e avaliação dos escores z: da estatura alvo (EA) e EF segundo o NCHS/CDC/2000 e da EF segundo Lyon e cols. Resultados: Pacientes foram classificados em três grupos: A (n = 16), tratamento com estrogênios e progestágenos; B (n = 21), tratamento com oxandrolona; C (n = 39), tratamento com hormônio de crescimento (GH) e oxandrolona. Não houve diferença no escore z da EA entre os grupos e no escore z da EF entre A e B. O escore z da EF do grupo C foi maior que o dos outros grupos, maior que 2 DP segundo Lyon e no percentil 3 da curva NCHS/CDC. Análise de regressão múltipla mostrou tipo de tratamento (p < 0,001) e estatura materna (p = 0,02) como fatores que mais influenciaram a EF. Conclusão: GH mais OX e estatura materna contribuíram significativamente para aumento da EF na ST.

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Growth hormone therapy of Turner's syndrome: Beneficial effect on adult height

Cited by 242 publications

References 12 publications

Low-dose Growth Hormone Treatment (0.175 mg/kg/week) for Short Stature in Patients with Turner Syndrome: Data from KIGS Japan

Low-dose Growth Hormone Treatment (0.175 mg/kg/week) for Short Stature in Patients with Turner Syndrome: Data from KIGS Japan

Adult height in girls with Turner syndrome treated from before 6 years of age with a fixed per kilogram GH dose

Estatura final (EF) em síndrome de Turner (ST): experiência de 76 casos acompanhados na Unidade de Endocrinologia Pediátrica do Hospital de Clínicas da Universidade Federal do Paraná

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