Growth impairment following irradiation in one of a pair of monozygotic twins

Lyons, A.R.; Grebbell, F. S.; Nevin, N. C.

doi:10.1016/s0009-9260(73)80061-3

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…Currently, the field is limited to oversimplified thresholds to guide RT planning to at least provide a goal for normal tissue avoidance. Doses !15 Gy, 4 particularly those !30 Gy, 7,[13][14][15] have been associated with clinically measurable toxicities. These observations inform the common current clinical practice to restrict asymmetrical treatment to the epiphyseal growth plates to <15 Gy.…”

Section: Complexities Of a Standard Dose Constraintmentioning

confidence: 99%

A Road Map for Important Centers of Growth in the Pediatric Skeleton to Consider During Radiation Therapy and Associated Clinical Correlates of Radiation-Induced Growth Toxicity

Rao

Ladra

Dunn

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

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With the increasing use of advanced radiation techniques such as intensity modulated radiation therapy, stereotactic radiation therapy, and proton therapy, radiation oncologists now have the tools to mitigate radiation-associated toxicities. This is of utmost importance in the treatment of a pediatric patient. To best use these advanced techniques to mitigate radiation-induced growth abnormalities, the radiation oncologist should be equipped with a nuanced understanding of the anatomy of centers of growth. This article aims to enable the radiation oncologist to better understand, predict, and minimize radiation-mediated toxicities on growth. We review the process of bone development and radiationinduced growth abnormalities and provide an atlas for contouring important growth plates to guide radiation treatment planning. A more detailed recognition of important centers of growth may improve future treatment outcomes in children receiving radiation therapy.

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Section: Complexities Of a Standard Dose Constraintmentioning

confidence: 99%

A Road Map for Important Centers of Growth in the Pediatric Skeleton to Consider During Radiation Therapy and Associated Clinical Correlates of Radiation-Induced Growth Toxicity

Rao

Ladra

Dunn

et al. 2019

International Journal of Radiation Oncology*Biology*Physics

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The role of genetic factors in the etiology of wilms' tumor.Two pairs of monozygous twins with congenital abnormalities (Aniridia; hemihypertrophy) and discordance for wilms' tumor

Maurer

Pendergrass

Borges

et al. 1979

Cancer

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Wilms' tumor was diagnosed in two children each of whom has an identical twin. In one of the pairs of twins the aniridia syndrome with psychomotor retardation was present in both children, but Wilms' tumor was found in only one. In the other twins hemihypertrophy as well as Wilms' tumor were identified in one child, whereas neither of these abnormalities was present in her twin sister. These findings lend support to a hypothesis that the development of Wilms' tumor requires the occurrence of two successive mutational events, one of which may be a germinal mutation. The presence of aniridia, hemihypertrophy, or other associated congenital abnormalities may aid in distinguishing between hereditary and sporadic forms of Wilms' tumor.

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Irradiation

Peterson

2011

Physeal Injury Other Than Fracture

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Growth impairment following irradiation in one of a pair of monozygotic twins

Cited by 7 publications

References 6 publications

A Road Map for Important Centers of Growth in the Pediatric Skeleton to Consider During Radiation Therapy and Associated Clinical Correlates of Radiation-Induced Growth Toxicity

A Road Map for Important Centers of Growth in the Pediatric Skeleton to Consider During Radiation Therapy and Associated Clinical Correlates of Radiation-Induced Growth Toxicity

The role of genetic factors in the etiology of wilms' tumor.Two pairs of monozygous twins with congenital abnormalities (Aniridia; hemihypertrophy) and discordance for wilms' tumor

Irradiation

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