Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

Leroy, Valérie; Baudouin, Véronique; Alberti, Corinne; Guest, G.; Niaudet, Patrick; Loirat, Chantal; Deschenes, Georges; Czernichow, P; Simon, Dominique

doi:10.1007/s00467-009-1266-y

Cited by 17 publications

(8 citation statements)

References 32 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed effects of GC on growth were in accordance with those reported previously 11,12) . The cumulative dose of GC and height at the time of diagnosis were correlated with the linear growth of patients.…”

Section: )supporting

confidence: 92%

“…Results of other studies of the effects of immunosuppressants on the growth of nephrotic patients have suggested that growth retardation is caused mainly by long-term use of GC, and not by other immunosuppressants 1,10,11) . However, heterogeneous types and doses of immunosuppressants including CsA and mycophenolate mofetil were used in these studies.…”

Section: )mentioning

confidence: 99%

See 1 more Smart Citation

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

Lee

Kim

et al. 2016

Child Kidney Dis

View full text Add to dashboard Cite

This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS). Methods: Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorticoid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen patients were treated with GC alone and 18 were treated with GC and CsA. The cumulative doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (Δ height Z score/year). The associations between linear growth and clinical parameters were analyzed. Results: The linear growth of patients in the two groups was not significantly different (P=0.262). The Δ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumulative dose of GC and positively correlated with the Z score for height at the time of diagnosis. Conclusion: In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.

show abstract

Section: )supporting

confidence: 92%

Section: )mentioning

confidence: 99%

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

Lee

Kim

et al. 2016

Child Kidney Dis

View full text Add to dashboard Cite

show abstract

“…This study found that median height was stable throughout the first 5 years but that reductions in height SDS progressed over time, becoming statistically significant at 9 years. 38 Although most patients in this study did not reach the height of their genetic potential, adult height was normal for all but 2 patients. Interestingly, no correlation between cumulative steroid dose and change in height was found.…”

Section: Growthmentioning

confidence: 59%

Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management

Hampson

Band

2021

Nut in Clin Prac

View full text Add to dashboard Cite

Nephrotic syndrome is a common kidney disease during childhood that is characterized by alterations in glomerular filtration and leads to protein, fluid, and nutrient loss in the urine. Most patients experience peripheral, gravity-dependent edema; however, serious cases exhibit anasarca and ascites. Many long-term complications of the disease exist due to the underlying pathology and the therapies used for treatment, including metabolic bone disease, micronutrient deficiencies, and hyperlipidemia. Pharmacologic and nutrition interventions are key to appropriate management. Fluid and sodium restriction in combination with corticosteroids, albumin, and diuretics are used to manage edema. Steroid-sparing therapies like alkylating agents and calcineurin inhibitors and dietary modification to eliminate dairy and gluten may be warranted in patients with frequent relapses or steroid-refractory disease. Nutrition clinicians should familiarize themselves with the nuances of treating this disease to optimize care for children with nephrotic syndrome.

show abstract

“…In contrary, Leroy et al (2009) (19) followed 64 children with SDNS receiving long-term cyclosporine and steroid therapy which were retrospectively analyzed. During the 10-year follow-up period, height standard deviation score (HSDS) remained in the normal range in 47 patients but was below -2 SD in 17 patients.…”

Section: Moon Et Al (2014)mentioning

confidence: 99%

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

et al. 2017

View full text Add to dashboard Cite

Background: Children with nephrotic syndrome (NS) may be at risk for metabolic bone disease because of biochemical derangement caused by renal disease as well as steroid therapy. Osteocalcin (OC) functions as an inhibitor of bone mineralization. We aimed to evaluate linear growth and bone turnover markers (including serum osteocalcin) in children with steroid-dependant/frequentlyrelapsing and steroid resistant NS in comparison to a matched control group.

show abstract

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

Cited by 17 publications

References 32 publications

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

Pediatric Nephrotic Syndrome: Pharmacologic and Nutrition Management

Osteocalcin Level in Children with Steroid Dependent/Frequently Relapsing and Steroid Resistant Nephrotic Syndrome

Contact Info

Product

Resources

About