Growth in Children With Various Therapies for End-Stage Renal Disease

Fennell, Robert S.; Orak, John K.; Hudson, Terry M.; Garin, Eduardo H.; Iravani, Abdollah; Deusen, W.J. Van; Howard, Richard J.; Pfaff, William; Walker, R. Dixon; Richard, George A.

doi:10.1001/archpedi.1984.02140390020007

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…Children exhibiting accelerated growth (rates _> 100% of expected) generally had excellent allograft function. This observation has been previously reported [16,18] and would be expected from studies of children before and after transplantation with varying levels of renal insufficiency [17, 22, 24, 281 . We previously reported a series of transplant recipients in which 53% of the patients had a growth rate of greater than 80% [8]. Just over one-third of our patients in our current Steroid dosage and the use of an alternate day pattern of administration affected the achievement of expected growth velocity.…”

Section: Discussionmentioning

confidence: 75%

“…Using bone age to predict growth rate and expressing observed rates in terms of these expected values has been done previously to evaluate various treatment regimens in children with renal failure [1,8,31]. The chronological age [3,4,6,18] and the sex [4,6,11] of the pediatric allograft recipient have been shown to influence growth following transplantation.…”

Section: Discussionmentioning

confidence: 99%

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Statistical analysis of statural growth following kidney transplantation

et al. 1986

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Factors affecting the growth rates of 59 children and adolescents for the first 2 years following kidney transplantation were evaluated. The factors assessed were age at transplantation, renal function, prednisone dosage, donor source, and prior history of transplantation. The observed growth velocity was expressed as the percentage of the growth velocity predicted by bone age. Normal growth (greater than or equal to 80%) was exhibited by 37% of the patients and 22% had accelerated growth (greater than or equal to 100%). The chronological age at transplantation did not correlate significantly with growth when bone age was used as the reference for expected velocity. Males grew better than did females. There was a unique sex/race interaction with black males growing most rapidly. Better renal function, the ability to lower prednisone dosage, alternate day prednisone, and a decreasing diastolic blood pressure were positively correlated with better growth rates after transplantation. Donor source and prior history of transplantation did not significantly influence growth rate.

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Section: Discussionmentioning

confidence: 75%