Growth in steroid-responsive nephrotic syndrome: a study of 85 pediatric patients

Donatti, Teresinha Lermen; Koch, Vera H.; Fujimura, Maria Danisi; Okay, Yassuhiko

doi:10.1007/s00467-003-1142-0

Cited by 33 publications

(30 citation statements)

References 25 publications

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“…Only 16 (14.5%) patients in our series received prednisone as the only therapy during follow-up and, at the end of follow-up, 20 were dependent on low-dose steroids. Our data show that the stature of patients who continued to have renal function was affected, possibly due to the growthinhibitory effects of prolonged courses of steroid therapy [37]. At the end of follow-up about one-quarter of our cohort presented with stature below the third percentile.…”

Section: Discussionmentioning

confidence: 76%

Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis

et al. 2006

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The purpose of this retrospective cohort study was to report the clinical course of children and adolescents with primary focal segmental glomerulosclerosis (FSGS). The records of 110 patients with biopsy-proven FSGS admitted between 1972 and 2004 were retrospectively reviewed. Demographic, clinical and laboratory data were recorded and histopathological data were reanalyzed by one pathologist who had no information about the outcome of the patients. Renal survival analysis was performed using the Kaplan-Meier method. Differences between subgroups (response to corticosteroids) were assessed by the two-sided log rank test. The median age at admission was 5 years (range: 1-15 years). Forty-two patients (38.2%) presented with hematuria at admission, and 55 (50%) presented blood pressure levels above the 95th percentile. Mean follow-up time was 10 years (SD 5.5). Twenty-four patients (21.8%) presented chronic kidney disease (CKD). It was estimated that the probability of CKD was 8% at 5 years, 17% at 10 years, and 32% at 15 years after diagnosis of nephrotic syndrome. In conclusion, on the basis of the clinical and histological characteristics observed, apparently our cohort of idiopathic FSGS is comparable with other published series. However, the long-term overall renal survival seems to be better in our cohort.

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Section: Discussionmentioning

confidence: 76%

Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis

et al. 2006

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“…It is generally accepted that prolonged use of corticosteroids results in impaired growth (20,21). All of our patients developed NS at young age and were treated with corticosteroids for years.…”

Section: Growthmentioning

confidence: 82%

Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children

Kyrieleis¹,

Löwik²,

Pronk³

et al. 2009

Clinical Journal of the American Society of Nephrology

128

113

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Background and objectives: Frequently relapsing and steroid-dependent minimal-change nephrotic syndrome (MCNS) that originates in childhood can persist after puberty in >20% of patients. These patients require immunosuppressive treatment during several decades of their life. We examined long-term adverse effects of persistent nephrotic syndrome and immunosuppressive medications, focusing on renal function, growth, obesity, osteoporosis, hypertension, ocular complications, and fertility in adult patients with biopsy-proven childhood-onset MCNS. Molecular analysis was performed to evaluate a possible association of a complicated course of MCNS with podocyte gene mutations.Design, setting, participants, & measurements: We performed a prospective clinical examination of 15 adult patients that included serum and urine analysis; dual-energy x-ray absorptiometry; ophthalmologic examination; semen examination; and molecular analysis of NPHS1, NPHS2, CD2AP, and ACTN4 genes.Results: All patients had normal GFR. Most frequent long-term complications were hypertension (in seven of 15 patients) and osteoporosis in one third of patients. Oligozoospermia was found in one patient, reduced sperm motility in four of eight patients, and teratozoospermia in six of eight patients. Ophthalmologic examination revealed myopia in 10 of 15 patients and cataract in three of 15 patients.Conclusions: Children with MCNS that persists after puberty are at risk for complications such as osteoporosis, hypertension, cataract, and sperm abnormalities. Our study underscores a need for more effective and less toxic therapies for relapsing MCNS.

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“…Bu yönüyle çalışma-mız Donatti ve ark. (8) çalışmasıyla paralellik gösteri-yordu. Diğer bir çalışma olan Emma ve ark.…”

Section: Discussionunclassified

Evaluation of the advers effects of the treatment of nephrotic syndrome in children

Esmeray¹,

Emre²,

Yılmaz³

et al. 2017

Cocuk Dergisi

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Growth in steroid-responsive nephrotic syndrome: a study of 85 pediatric patients

Cited by 33 publications

References 25 publications

Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis

Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis

Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children

Evaluation of the advers effects of the treatment of nephrotic syndrome in children

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