This paper considers the evolution of Ukraine’s space-economy from 1990 to 2009, paying particular attention to comparative regional economic performance during the country’s expansionary phase from 1999 to 2008. This shows that Ukraine inherited from the Imperial and Soviet eras a space-economy that was amongst the most unbalanced in Europe. Furthermore post-Soviet regional trajectories intensified these territorial imbalances. The paper argues that these trajectories are linked to a wider political economy and especially to shifts in underlying development models and the characteristics of state power. The Orange Revolution marked a significant switch away from export-led industrial growth, which involved national accumulation towards a credit-fuelled consumption model that was reliant on importing foreign capital. The paper identifies three major types of specialized regional economy that persisted despite the change in development model. Nonetheless, their relative performance and contribution to national growth were affected by the shift in model. Centripetal tendencies were reinforced, which increased regional divergence. The paper argues that the Ukrainian space-economy is best understood as a series of historically rooted and relatively geographically bounded regional economies that are increasingly functionally integrated yet externally oriented.