Growth Inhibition and Induction of Apoptosis in Different Carcinoma Cell Lines by Euphorbia tirucalli Stem Extracts

Joshi, Kumud; Mandavia, M.K.; I.A., Bakayeva; kiya, Gola

doi:10.20546/ijcmas.2018.704.163

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…However, when the cellular antioxidant systems are damaged, antioxidants are insufficient to neutralise ROS, and then oxidative stress occurs [27,29]. Moreover, in a pathological process, ROS are responsible for damaging proteins, lipids and nucleic acids [29,30]. Nonetheless, bioactive compounds are strongly linked to the radical scavenging capacity and protect the cell against oxidative DNA damage [12,25,31].…”

Section: Relationship Between Ros and Cervical Cancermentioning

confidence: 99%

Pharmacology Evaluation of Bioactive Compounds that Regulate Cervical Cancer Cells

Salinas-Santander¹,

Alvarez-Ortiz²,

Valdes³

et al. 2019

Pharmacognosy - Medicinal Plants

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Cancer has been a public health problem that has gained a lot of death. However, in spite of the advances in the diagnosis and treatment of cervical cancer, women follow the struggle versus this disease. Also, those patients suffer from limited efficacy and specificity, undesirable effects, drug resistance, and a high cost of treatments. Currently, several studies have demonstrated the efficiency of natural products, called bioactive compounds, against cervical cancer cell lines. Bioactive compounds, including polyphenols and phenolic acids or flavonoids, etc., have antioxidant and pro-oxidant properties. These compounds are efficacy and show high specificity because probably they act as anti-oxidant and pro-oxidant. The prooxidant activity obstructs growth factors related to different signalling pathways that trigger cancer. Although, usually this kind of compounds helps for dispatching the apoptosis in cervical cancer cell. The aim of this chapter is reviewing how bioactive compounds affect the signalling pathways.

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Section: Relationship Between Ros and Cervical Cancermentioning

confidence: 99%

Pharmacology Evaluation of Bioactive Compounds that Regulate Cervical Cancer Cells

Salinas-Santander¹,

Alvarez-Ortiz²,

Valdes³

et al. 2019

Pharmacognosy - Medicinal Plants

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“…Nowadays, an innumerable number of active ingredients derived from medicinal plants have been used in pharmacology (Joshi et al, 2018). Indeed, it is now known that medicinal plants have antibacterial, antifungal, anti-in ammatory, antioxidant, and analgesic potential, among others (Andrea et al, 2016;Cristian et al, 2017;Pérez-Narváez et al, 2019;Prabha et al, 2008;Rivas-Morales et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

In vitroantifungal activity of polymeric nanoparticles loaded with the methanolic extract of Euphorbia tirucalli

Heya¹,

-Star²,

Rivas-Morales³

et al. 2023

Preprint

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The therapeutic potential of medicinal plants is known as an alternative in treatment of human affections; in effect, the conventional application of these medicinal sources has several limitations like low bioavailability, solubility, and stability, which affect its pharmacological efficacy. In recent decades, extraordinary advances have been made in new drug delivery systems using nanocarriers. This work consisted in determining the in vitro antifungal activity of the methanolic extract of Euphorbia tirucalli formulated in polymeric nanoparticles. The antifungal activity was determined by the microdilution method in 96-well microplates, applying nanoparticles loaded with plant extract (NP-Ext) obtained by nanoprecipitation on clinical isolates of Trichophyton rubrum and T. interdigitalis. Regarding the nanoparticles, the lots used did not present significant differences in their physicochemical characteristics, with a size of 91.885 ± 1.621nm, polydispersity index of 0.152 ± 0.025 and Z-potential of -6.047 ± 0.987. The quantification of the extract in the polymeric matrix was determined by infrared spectroscopy (FT/IR), where an efficiency and encapsulation percentage of 22.15 ± 0.82 and 2.95 ± 0.11, respectively, were obtained. The in vitro antifungal activity of the crude and formulated extract was obtained calculating the Minimum Inhibitory Concentration (MIC) of each one; a MIC of 125 µg/mL was obtained against T. rubrum and T. interdigitaliswith the crude extract, while a MIC value of 55.55 and 0.1 µg/mL was obtained with NP-Ext, respectively, against these same. Conclusions: biological activity is closely linked to the phytochemical profile of the extract; while the improvement of said potential with the NP-Ext with the dosage form was directly related to the physicochemical characteristics of the nanocarrier.

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In vitro antifungal activity of polymeric nanoparticles loaded with Euphorbia tirucalli extract

Heya,

Verde-Star,

Rivas-Morales

et al. 2024

Braz. J. Biol.

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The therapeutic potential of medicinal plants is known as an alternative in treatment of human affections; in effect, the conventional application of these medicinal sources has several limitations like low bioavailability, solubility and stability, which affect its pharmacological efficacy. In recent decades, extraordinary advances have been made in new drug delivery systems using nanocarriers. This work consisted in determining the in vitro antifungal activity of the methanolic extract of Euphorbia tirucalli formulated in polymeric nanoparticles. The antifungal activity was determined by the microdilution method in 96-well microplates, applying nanoparticles loaded with plant extract (NP-Ext) obtained by nanoprecipitation on clinical isolates of Trichophyton rubrum and T. interdigitalis. Regarding the nanoparticles, the lots used did not present significant differences in their physicochemical characteristics, with a size of 91.885 ± 1.621nm, polydispersity index of 0.152 ± 0.025 and Z-potential of -6.047 ± 0.987. The quantification of the extract in the polymeric matrix was determined by infrared spectroscopy (FTIR), where an efficiency and encapsulation percentage of 22.15 ± 0.82 and 2.95 ± 0.11, respectively, were obtained. The in vitro antifungal activity of the crude and formulated extract was obtained calculating the Minimum Inhibitory Concentration (MIC) of each one; a MIC of 125 µg/mL was obtained against T. rubrum and T. interdigitalis with the crude extract, while a MIC value of 55.55 and 0.1 µg/mL was obtained with NP-Ext, respectively, against these same. Conclusions: biological activity is closely linked to the phytochemical profile of the extract; while the improvement of said potential with the NP-Ext with the dosage form was directly related to the physicochemical characteristics of the nanocarrier.

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Growth Inhibition and Induction of Apoptosis in Different Carcinoma Cell Lines by Euphorbia tirucalli Stem Extracts

Cited by 3 publications

References 8 publications

Pharmacology Evaluation of Bioactive Compounds that Regulate Cervical Cancer Cells

Pharmacology Evaluation of Bioactive Compounds that Regulate Cervical Cancer Cells

In vitroantifungal activity of polymeric nanoparticles loaded with the methanolic extract of Euphorbia tirucalli

In vitro antifungal activity of polymeric nanoparticles loaded with Euphorbia tirucalli extract

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