Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites

Fernández-Gómez, Rodolfo; Zerrouk, H.; Sebti, Fatima; Loyens, Marc; Benslimane, A.; Ouaissi, M. A.

doi:10.1016/0041-0101(94)90366-2

Cited by 39 publications

(34 citation statements)

References 15 publications

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“…Our results were consistent with these findings, in which promastigotes presented susceptibility to the purified enzyme. Unlike other venoms (9,10), no other active fraction could be observed. This fact can be ascribed to major differences in the venom composition.…”

Section: Fig 4 Effective Dose 50% (Ec 50 ) Of Crude B Moojeni Venomentioning

confidence: 46%

Bothrops moojeni Venom Kills Leishmania spp. with Hydrogen Peroxide Generated by Its -Amino Acid Oxidase

Tempone

Andrade²,

Spencer

et al. 2001

Biochemical and Biophysical Research Communications

111

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Section: Fig 4 Effective Dose 50% (Ec 50 ) Of Crude B Moojeni Venomentioning

confidence: 46%

Bothrops moojeni Venom Kills Leishmania spp. with Hydrogen Peroxide Generated by Its -Amino Acid Oxidase

Tempone

Andrade²,

Spencer

et al. 2001

Biochemical and Biophysical Research Communications

111

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“…Snake venom -Venom from Cerastes cerastes and Naja haje inhibited the proliferation of epimastigotes of T. cruzi at levels similar to Bz, and that of C. cerastes was also active against trypomastigotes (Fernandez-Gomez et al 1994).…”

Section: Drugs Derived From Natural Sourcesmentioning

confidence: 99%

A Critical Review on Chagas Disease Chemotherapy

Coura¹,

Castro

2002

Mem. Inst. Oswaldo Cruz

846

444

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“…Because of this diversity, these poisons generally exhibit potential antiparasitic activity. In this context, the antileishmanial effect of the T. discrepans scorpion venom has been observed [5], and also the effect of the Cerastes cerastes venom on the growth rates of T. cruzi and L. donovani [6]. Anti- L .…”

Section: Discussionmentioning

confidence: 99%

“…One study demonstrated the activity of Tityus discrepans scorpion venom by inducing structural modifications in the promastigotes of Leishmania mexicana [5]. There is also a study on the effect of Cerastes cerastes snake venom, popularly known as the horned rattlesnake, on the growth rates of Trypanosoma cruzi and L. donovani [6]. An effect of crotalic venom, inhibiting the growth of L. amazonensis , has been reported in the context of the toxins from the genus Crotalus and antileishmanial activity [7].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Microparticles Containing Crotamine Isolated from <b><i>Crotalus durissus terrificus</i></b> Display Antileishmanial Activity in vitro

Macedo

Barros²,

Ferreira³

et al. 2015

Pharmacology

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Background/Aims: To evaluate antileishmanial activity of crotamine, a toxin isolated from Crotalus durissus terrificus, in solution form and encapsulated in biodegradable microparticles in vitro. Methods: Particles were analyzed on-chip by surface plasmon resonance and characterized by testing their diameters, zeta potential and encapsulation rate. The viability of promastigotes as well as murine macrophages was assessed. Furthermore, the phagocytic index was determined for macrophages, and cell supernatants were collected for the determination of TNF-α levels. An infection assay using Leishmania amazonensis-infected macrophages was also conducted. Results: The diameters and zeta potential of control particles (1.35 μm; -12.3 mV) and of those containing crotamine (3.09 μm; -20.9 mV) were adequate for the assays conducted. Crotamine-loaded particles were better captured by macrophages than control particles (increase of 12% in the phagocytic index), leading to increased TNF-α levels (196 pg/ml), and they also induced a significant decrease in the numbers of amastigotes compared to infected macrophages only. Conclusion: The approach presented here opens the possibility of working with safe concentrations of encapsulated toxins to reach antileishmanial effects.

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Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites

Cited by 39 publications

References 15 publications

Bothrops moojeni Venom Kills Leishmania spp. with Hydrogen Peroxide Generated by Its -Amino Acid Oxidase

Bothrops moojeni Venom Kills Leishmania spp. with Hydrogen Peroxide Generated by Its -Amino Acid Oxidase

A Critical Review on Chagas Disease Chemotherapy

Biodegradable Microparticles Containing Crotamine Isolated from <b><i>Crotalus durissus terrificus</i></b> Display Antileishmanial Activity in vitro

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