Growth-inhibitory activity of bone marrow cells during CCl4-induced liver cirrhosis

Abstract

During CCl4-induced liver cirrhosis, cells of the hemopoiesis-inducing microenvironment in the bone marrow of BALB/c mice produced activity inhibiting the growth of erythropoiesis and granulomonocytopoiesis precursors. Stimulation with yeast polysaccharide zymosan increased the inhibitory activity (especially in relation to granulomonocytic precursors). The highest growth-inhibitory activity was produced by the bone marrow adherent fraction (residual bone marrow macrophages). Tumor necrosis factor-a is probably responsible for the inhibition of the growth of myeloid precursors in mice with CC14-induced liver cirrhosis.