Growth kinetics of hemopoietic fetal stem cells

The infection of newborn mice with a mouse erythroblastotic virus increases the number of hematopoietic stem cells in the spleen. Upon retransplantation of these stem cells into intermediate recipient mice certain growth parameters (doubling time, self renewal and extinction probability, etc.) which are abnormal when measured by techniques which avoid the intermediate recipient step, appear to be reverted toward normal values. The "normalization" of the stem cells is explained by the change in the environment supporting CFU growth during transplantation.

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Hematopoietic stem cells from mice with erythroblastosis

Hajdik

Niewisch

Matioli

1971

Journal Cellular Physiology

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The effect of hypertransfusion on the growth of mouse foetal liver cells transplanted into irradiated, adult recipients: Failure to detect a differential effect between cells from early and late foetuses

Tarbutt

Cole

1971

Journal Cellular Physiology

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Erythropoiesis can be reinstated in lethally irradiated mice by transplantation of adult bone marrow or liver cells from foetuses at any stage of gestation beyond the eleventh day. Hypertransfusion of the recipients abolishes erythropoiesis resulting from the transplants, even when the transplants are derived from foetuses at a very early stage of development. This suggests that erythropoietin is necessary for the successful growth of these early foetal transplants, at least in the environment of the irradiated recipient. These results are at variance with an earlier report on the susceptibility of early foetal liver transplants to suppression by hypertransfusion.

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Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

Micklem

Ford

Evans

et al. 1972

Journal Cellular Physiology

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The relative proliferative capacity of haematopoietic cell populations derived from 22-week-old adult bone marrow and 14-18 day foetal liver has been studied i n lethally irradiated syngeneic recipients by means of chromosome markers. Although starting a t a disadvantage i n terms of the number of colony-forming units (stem cells) injected, the foetal liver-derived populations steadily increased their relative numbers i n the myeloid and lymphoid tissues over a period of several weeks until a plateau was reached. It is suggested that stem cells in foetal liver have, on average, a higher intrinsic capacity for self-renewal than do those i n bone marrow, falls to the adult level within about ten weeks of transfer.

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Growth kinetics of hemopoietic fetal stem cells

Cited by 6 publications

References 9 publications

Hematopoietic stem cells from mice with erythroblastosis

Hematopoietic stem cells from mice with erythroblastosis

The effect of hypertransfusion on the growth of mouse foetal liver cells transplanted into irradiated, adult recipients: Failure to detect a differential effect between cells from early and late foetuses

Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

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