Growth of a TiNb adhesion interlayer for bioactive coatings

Tolde, Zdeněk; Starý, V.; Cvrček, Ladislav; Vandrovcová, Marta; Remsa, Jan; Daniš, S.; Krčil, Jan; Bačáková, Lucie; Špatenka, Petr

doi:10.1016/j.msec.2017.07.013

Cited by 17 publications

(11 citation statements)

References 27 publications

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“…In turn, Milan et al [114] deposited Cu/a-C:H thin coating onto Ti alloys via magnetron sputtering and they showed that applied coating improved antibacterial activity as well as stimulated angiogenesis and osteogenic differentiation of human BMDSCs in vitro. Similarly, Tolde et al [115] applied magnetron sputtering techniques to cover Ti alloys and stainless steel with niobium titanium (TiNb) coating. Resultant materials were subsequently applied as a substrate for deposition of BaTiO 3 film characterized by better biocompatibility in comparison with pure TiNb.…”

Section: Magnetron Sputtering Modificationsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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Section: Magnetron Sputtering Modificationsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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“…In addition to the novel types of alloys, a wide range of modifications of the physical and chemical properties of the material surface has been developed in order to enhance its attractiveness for the adhesion and growth of bone cells. These modifications include changes in chemical composition of the material surface (e.g., introduction of various functional groups, which can increase its polarity and wettability), optimization of the surface roughness and morphology [2,3], and particularly creation of electrically active surfaces [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Beta-Titanium Alloy Covered by Ferroelectric Coating–Physicochemical Properties and Human Osteoblast-Like Cell Response

et al. 2021

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Beta-titanium alloys are promising materials for bone implants due to their advantageous mechanical properties. For enhancing the interaction of bone cells with this perspective material, we developed a ferroelectric barium titanate (BaTiO3) coating on a Ti39Nb alloy by hydrothermal synthesis. This coating was analyzed by scanning electron and Raman microscopy, X-ray diffraction, piezoresponse force microscopy, X-ray photoelectron spectroscopy, nanoindentation, and roughness measurement. Leaching experiments in a saline solution revealed that Ba is released from the coating. A progressive decrease of Ba concentration in the material was also found after 1, 3, and 7 days of cultivation of human osteoblast-like Saos-2 cells. On day 1, the Saos-2 cells adhered on the BaTiO3 film in higher initial numbers than on the bare alloy, but they were less spread, and their initial proliferation rate was slower. These cells also contained a lower amount of beta1-integrins and vinculin, i.e., molecules involved in cell adhesion, and produced a lower amount of collagen I. This cell behavior was attributed to a higher surface roughness of BaTiO3 film rather than to its potential cytotoxicity, because the cell viability on this film was very high, reaching almost 99%. The amount of alkaline phosphatase, an enzyme involved in bone matrix mineralization, was similar in cells on the BaTiO3-coated and uncoated alloy, and on day 7, the cells on BaTiO3 film attained a higher final cell population density. These results indicate that after some improvements, particularly in its roughness and stability, the hydrothermal ferroelectric BaTiO3 film could be promising coating for improved osseointegration of bone implants.

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“…The properties of an oxide layer are dependent on the substrate material, presence of an interlayer, method of preparation and its conditions, etc. [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…One of the most common biomaterials -Ti6Al4V alloy -may be a cause of health issues. Its oxide layer also contains, in low amounts, ions of Al and V, which are released into a human body [3]. The newly developed titanium β alloys exhibits better biocompatibility ensured by a low quantity of alloying elements (Nb or Ta for example) present in the oxide layer [1,[4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Characterization of Anodic Oxide Layers on Selected Bio-Compatible Titanium Alloys

et al. 2018

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Oxide layers on titanium alloy surfaces have an influence on bio-compatibility and corrosion resistance. In order to improve them, properties of oxide layers are examined. The oxide layer can be prepared by different methods and under various conditions. This results in a creation of layers showing different composition, structure, properties, stability, adhesion and biocompatibility. In the presented paper, samples of three titanium alloys were used: Commercially Pure (CP) titanium grade 2, Ti6Al4V alloy and -titanium alloy Ti-39 wt.% Nb. Samples were anodically (1MH2SO4 / 100V/ 1 hour) oxidized. Changes in surface colouration and roughness were observed. The thickness of oxide layers was measured using a scanning electron microscope (SEM). The SEM was then used for observation of the surface topography of oxidized samples. The chemical composition of the surface layers was defined by X-ray photoelectron spectroscopy (XPS).

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Growth of a TiNb adhesion interlayer for bioactive coatings

Cited by 17 publications

References 27 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Beta-Titanium Alloy Covered by Ferroelectric Coating–Physicochemical Properties and Human Osteoblast-Like Cell Response

The Characterization of Anodic Oxide Layers on Selected Bio-Compatible Titanium Alloys

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