Growth of Candida Albicans on Keratin as Sole Source of Nitrogen

Kapica, L.; Blank, F.

doi:10.1159/000255990

Cited by 60 publications

(13 citation statements)

References 12 publications

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“…We had already pointed out in our previous paper [10] th a t the amino acids found in culture liquids of C. albicans corresponded with those identified by Blackburn [2] among the degradation products of wool digested with papain in sodium sulphite solution. They also corresponded with those identified by Daniels [6] in cultures of Microsporum canis with hum an hair as sole source of nitrogen.…”

Section: Discussionsupporting

confidence: 61%

“…Growth in yeast phase characterized the cultures of this organism whereas C. albicans developed more filamentous growth under similar conditions [10].…”

Section: Resultsmentioning

confidence: 99%

“…( 1) Evidence for the keratinolytic activities o f C. parapsilosis C. parapsilosis grew well with keratin as sole source of nitrogen under almost the same conditions as did C. albicans [10], although in either case the optimal conditions for growth might not have pre vailed. Glucose was necessary to induce growth, but growth continued after glucose had been depleted from the media.…”

Section: Discussionmentioning

confidence: 99%

“…In an earlier investigation [10] Candida albicans was grown with hoof and nail keratin as sole source of nitrogen in order to investigate the keratinolytic activities of the organism which might account for its pathogenicity for keratinized tissues. It was found th a t C. albicans could grow in media containing keratin and glucose with and w ithout the addition of salts.…”

Section: Introductionmentioning

confidence: 99%

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Growth of Candida Parapsilosis with Keratin as Sole Source of Nitrogen

Kapica¹,

Blank²

1958

Dermatology

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Section: Discussionsupporting

confidence: 61%

“…Growth in yeast phase characterized the cultures of this organism whereas C. albicans developed more filamentous growth under similar conditions [10].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Growth of Candida Parapsilosis with Keratin as Sole Source of Nitrogen

Kapica¹,

Blank²

1958

Dermatology

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“…Keratinolytic enzymes have been described from Aspergillus flavus and Aspergillus niger (Koh, Santoro, and Messing 1958) and the growth of Oandida albicans on keratin as sole source of nitrogen has been reported (Kapica and Blank 1957). Aerobic, mesophilic, spore-forming members of the genus Bacillus have also been implicated in the degradation of wool.…”

Section: Introductionmentioning

confidence: 99%

The Digestion of Wool by a Keratinolytic Bacillus

Molyneux¹

1959

Aust. Jnl. Of Bio. Sci.

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SummaryThe occurrence, isolation, and characteristics of an aerobic, mesophilic, spore-forming bacillus capable of separating wool and hair into their constituent cuticular and cortical cells are described.The organism was isolated from the contents of experimentally induced dermoid cysts implanted on the mid-lateral region of a single sheep. Examination of wool samples from these cysts showed the wool to be degraded, as evidenced by the presence of numerous free cortical and cuticular cells. The contents of experimental cysts on other sheep showed no evidence of bacterial contamination 13 weeks after implantation, and wool samples from these cysts were normal.Disruption of wool fibres occurred in vitro and in vivo. The evidence suggests that the organism is capable of attacking native wool protein.In the case of this one sheep a comparison is drawn between the environment necessary for the development of "pink rot" and the intracystic environment of the wool.It is also suggested that the technique of cyst implantation could be developed for the production of sterile native (untreated) wool and sterile adult skin.

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Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response

Ray¹,

Wuepper²

1978

Archives of Dermatology

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Of six species of Candida applied epicutaneously to rodents, only C albicans and C stellatoidea penetrate the stratum corneum and produce inflammation. The role of the stratum corneum and produce inflammation. The role of the stratum corneum in experimental murine Candida infections was studied, therefore, by intraepidermal injection of blastospores in mice that received a prior injection of staphylococcal epidermolysin. All six species caused accumulation of neutrophils if placed within an intraepidermal cleft in contact with viable epidermis. The role of serum complement in cutaneous candidiasis was also studied in vivo in rodents depleted of complement with cobra venom factor or deficient in the fifth component of complement. These animals failed to develop neutrophilic inflammatory responses to the six Candida species tested in contrast to control animals. Candida albicans, C stellatoidea, and C tropicalis developed extensive hyphal proliferation with invasion of the entire cutis and subcutis in these animals. The stratum corneum provides an effective barrier to some, but not all Candida species. When this barrier is penetrated, complement mediates an acute neutrophilic pustular response that resticts Candida proliferation and prevents deep invasion of tissue.

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Growth of Candida Albicans on Keratin as Sole Source of Nitrogen

Cited by 60 publications

References 12 publications

Growth of Candida Parapsilosis with Keratin as Sole Source of Nitrogen

Growth of Candida Parapsilosis with Keratin as Sole Source of Nitrogen

The Digestion of Wool by a Keratinolytic Bacillus

Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response

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